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This use of gabapentin for the treatment of anxiety is referred to as an off-label use, meaning there is limited data on its effectiveness to treat anxiety. Other off-label uses include treating alcohol withdrawal for alcohol use disorder and hot flashes associated with menopause. The rise in gabapentin prescribing is multifactorial but thought to be due in part to efforts by the pharmaceutical industry to promote the use of the medication for off-label uses. (In 2004, the manufacturer of Neurontin, Pfizer, pleaded guilty to multiple counts of illegally promoting the off-label use of gabapentin, resulting in nearly $430 Gabapentin is widely prescribed off label in medical practice, including psychiatry. The U.S. Food and Drug Administration (FDA) warned of risks associated with gabapentin combined with central nervous system depressant (CNS-D) drugs, which are commonly prescribed in psychiatric treatment. vising against the combined use of gabapentin with central nervous system depressant (CNS-D) drugs, many of which are used in psychiatric treatment regimens (14 ). A range of short-term and long-term adverse outcomes can result from concomitant use of CNS-D drugs and gabapentin that jeop-ardize the previously touted favorable safety pro file Can gabapentin be used as an alternative to antipsychotic medications in treating certain psychiatric disorders? Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder often require long-term treatment with antipsychotic medications. gabapentin treatment mania or hypomania occurred, ad-verse events, maximum and maintenance gabapentin dose and duration of treatment, indications for treatment with gabapentin, whether or not gabapentin was discon-tinued, reason for discontinuation of gabapentin, family history of psychiatric disorders, age at onset of illness, Sir: Gabapentin is a newer anticonvulsant approved for use as an adjunct agent in the treatment of partial seizures with or without secondary generalization. 1 Recent publications indicate that gabapentin has been useful in a wide array of psychiatric conditions including anxiety disorders, 2 alcohol withdrawal, 3 bipolar disorder, 4 behavioral More clinical trials with larger patient populations are needed to support gabapentin’s off-label use in psychiatric disorders and substance use disorders. It is worth noting that numerous clinical studies that are discussed in this review are open-label trials, which are inherently less rigorously analyzed. Gabapentin gained FDA approval in 1993 under the brand name Neurontin as an adjunctive therapy in the treatment of partial onset seizures, and subsequently for the treatment of postherpetic neuralgia in adults in 2002. It became available as a generic in 2004. Explore gabapentin's role in mental health treatment, including its uses, benefits, and potential risks. Learn about dosage, effectiveness, and side effects. 1. Gabapentin may be effective for treating depression and anxiety, among other things. Although gabapentin was traditionally used to treat seizures, it is now sometimes used as a mood stabilizer for depression and bipolar disorder because it calms neurons in the brain, and it may be effective for anxiety too. Gabapentin is commonly used off-label in the treatment of psychiatric disorders with success, failure, and controversy. A systematic review of the literature was performed to elucidate the evidence for clinical benefit of gabapentin in psychiatric disorders. Gabapentin: Gabapentin is indicated for postherpetic neuralgia and serves as adjunctive therapy for managing partial seizures (with or without secondary generalization) in adults and pediatric patients aged 3 or older. But since it’s been available, gabapentin has also been used off-label in psychiatry to treat patients with treatment-resistant mood and anxiety disorders as well as alcohol-withdrawal and Gabapentin is commonly used off-label in the treatment of psychiatric disorders with success, failure, and controversy. A systematic review of the literature was performed to elucidate the evidence for clinical benefit of gabapentin in psychiatric disorders. Gabapentin is licensed for use in the USA for the treatment of focal seizures and post-herpetic neuralgia [1] and in the UK for focal seizures and peripheral neuropathic pain [2]. Pregabalin Evidence supports gabapentin as a treatment for alcohol withdrawal and alcohol use disorder. There is sufficient evidence to consider gabapentin as a third-line treatment for social anxiety disorder and severe panic disorder. Objective: Gabapentin (GBP) is an anticonvulsant medication that is also used to treat restless legs syndrome (RLS) and posttherapeutic neuralgia. GBP is commonly prescribed off-label for psychiatric disorders despite the lack of strong evidence. Gabapentin is prescribed for several uses, including to treat nerve pain caused by injury or illness . It should not be used as a painkiller unless prescribed by your doctor for this use. Does gabapentin cause weight gain? Weight gain is a potential side effect of gabapentin treatment but occurs in a small number of cases. An emerging body of experience suggests the potential utility of gabapentin for a number of psychiatric disorders including intermittent explosive disorder , mania , and pain syndromes . Preclinical data suggest the potential anxiolytic effect of gabapentin ( 6 ).
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