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In addition, we required at least a 2-day length of stay after surgery to define gabapentin exposure status, which may have limited the generalizability of our findings. However, the results did not change when we defined the exposure on the day of surgery without requiring a minimum length of stay after surgery. Gabapentin is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a unique mechanism of action, which differentiates it from other commonly used drugs. Various studies have shown that perioperative use of gabapentin reduces postoperative pain. Perioperative gabapentin, 1200 mg, administered preoperatively plus 600 mg every 8 hours continued for 72 hours after surgery did not affect time to pain cessation, the rate of pain resolution, or the proportion of patients with chronic pain at 6 months or 1 year following surgery. In response to the opioid crisis, surgeons nationwide have sought to decrease opioid use by adopting opioid-sparing multimodal medication regimens to treat perioperative pain. 1 For example, gabapentinoids (gabapentin and pregabalin) are now commonly administered during the perioperative period as part of “enhanced recovery after surgery Yu L, Ran B, Li M, et al. Gabapentin and pregabalin in the management of postoperative pain after lumbar spinal surgery: a systematic review and meta-analysis. Spine 2013; 38:1947–1952. [Google Scholar] 10. Hwang SH, Park IJ, Cho YJ, et al. The efficacy of gabapentin/pregabalin in improving pain after tonsillectomy: a meta-analysis. Peri-operative gabapentin administration is effective in reducing pain scores, opioid requirements and opioid-related adverse effects in the first 24 hours after surgery. No serious side-effects were observed, though sedation was associated with gabapentin use. In addition, we required at least a 2-day length of stay after surgery to define gabapentin exposure status, which may have limited the generalizability of our findings. However, the results did not change when we defined the exposure on the day of surgery without requiring a minimum length of stay after surgery. Conclusions Pain management after total hip arthroplasty (THA) varies and has been widely studied in recent years. Gabapentin as a third-generation antiepileptic drug that selectively affects the nociceptive process has been used for pain relief after THA. This Among patients with new prescriptions, 23% (n=4,031) continued to receive gabapentin prescriptions at 90+ days after surgery. Those with prolonged use were more likely to be women (24% vs 21%), be non-white (24% vs 23%) and have undergone emergency surgery (38% vs 22%). Gabapentinoids were also ineffective in preventing chronic pain from developing after surgery, one of the primary justifications for using the drugs postoperatively. More than one-fifth of older adults prescribed gabapentin postoperatively filled a prescription >90 days after discharge, especially among patients with more comorbidities and concurrent prolonged opioid use, increasing the risk of adverse drug events and polypharmacy. The observed reduction in postoperative opioid consumption with preoperative gabapentin supports the notion of incorporating gabapentin in the multimodal analgesic treatment plans for postoperative pain management among patients undergoing elective surgery. Gabapentin appears safe and well tolerated when used for persistent post-operative and post-traumatic pain in thoracic surgery patients, although minor side effects do occur. Gabapentin may relieve refractory chest wall pain in some of these patients, particularly those with more severe pain. Furthe Medications are often prescribed for short-term pain relief after surgery or an injury. Many types of medicines are available to help manage pain, including opioids and non-steroidal anti-inflammatory drugs (NSAIDs). Your doctor may use a combination of medications to improve pain relief and to minimize the need for opioids. Purpose of review: This review summarizes the risks and benefits of gabapentinoids (gabapentin and pregabalin) for perioperative pain control and the controversies surrounding their use in a variety of settings. We review current literature with the goal of providing patient-centric and procedure-specific recommendations for the use of these They found that gabapentin resulted in a 35% reduction in total analgesic consumption in the first 24 hours following surgery. Gabapentin also resulted in 27% to 39% reduction in visual analog scale (VAS) pain scores in the first 24 hours postoperatively. The purpose of this review is to critically appraise the evidence for the use of gabapentinoids for acute pain management and its impact on the development of chronic pain after surgery. Recent findings: Recent meta-analyses have revealed that prior data likely have overestimated the beneficial effects of gabapentinoids in acute perioperative Similarly, aside from 24 h after surgery, gabapentin significantly reduced pain with movement (25–27,31,34,35,37,38) by 18% to 28% (VAS 8.2 mm to 10.2 mm) after surgery . The pooled effects on VAS pain scores displayed significant heterogeneity, which was not explained by subgroup analyses based on surgical procedure, gabapentin dose or study Perioperative gabapentin upped the risk of delirium, new antipsychotic use, and pneumonia in older adults after major surgery, a retrospective study showed.
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