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Maximum dose: 2400 to 3600 mg/day; doses up to 2400 mg/day have been well tolerated in long-term studies; doses of 3600 mg/day have be used in a small number of patients for a relatively short duration and have been well tolerated. We would like to show you a description here but the site won’t allow us. Dosages up to 2400 mg/day have been well tolerated in long term clinical studies. Doses of 3600 mg/day have also been administered to a small number of patients for a relatively short duration, and have been well tolerated. So far, there have been only two peer-reviewed case reports of death[1][2]from gabapentin toxicity (related to gabapentin overdose). Despite this low statistic, gabapentin abuse as a suicide attempthas risen over the years. While this means gabapentin is a relatively safe drug, it still should not be ingested in large amounts. (A) Observed and predicted steady-state plasma gabapentin concentrations following administration of 1200 mg/day (solid line, open circle), 2400 mg/day (short dashed line, triangle pointing downwards), 3600 mg/day (long dashed line, square), and 4800 mg/day (medium dashed line, triangle pointing upwards) given in equally divided doses every 8 h. Recommended dose: 600 mg once daily, taken with food in the evening. Treatment is usually long-term. Initial dose: 300 mg once daily, with gradual increases as needed. Maintenance dose: 900-2400 mg per day, divided into three doses. The duration of treatment depends on symptom control. Key Takeaways Understanding Gabapentin: Uses and Effects Gabapentin, known by the brand names Neurontin, Gralise, and others, is a medication primarily used to treat seizures and neuropathic pain. It is often prescribed for managing postherpetic neuralgia in adults, which is pain following a shingles infection. Gabapentin has also found off-label use for a variety of [] We would like to show you a description here but the site won’t allow us. For adults, your gabapentin dosage varies depending on your medical conditions and which form you’re taking. The maximum dosage is 3,600 mg per day. For children, the dosage is based on age and body weight. Gabapentin is available as a lower-cost generic. But certain products are brand-only. Memory loss and other cognitive adverse effects are well known to occur with gabapentin (brand name Neurontin) and they appear to be dose related, meaning higher doses result in a higher incidence rate. In your situation, your dose far exceeds the maximum recommended daily dose, which is 3,600mg (given as divided doses throughout the day). 1,200 mg/day 47% is absorbed; 2,400 mg/day 34% is absorbed; Doing the math here on how much is actually absorbed. 900X0.6 = 540mg; 1,200X0.47 = 564mg; 2,400X0.34 = 816mg; Always keep in mind that these are approximations, but I think these numbers demonstrate what I’m talking about. A gabapentin overdose can be dangerous or even deadly. Some factors can increase the risk of a fatal overdose, such as taking several substances at once. Gabapentin overdose symptoms can include: Drowsiness; Movement difficulties; Dizziness; Nausea or vomiting; Rapid heartbeat; Low blood pressure Bioavailability of gabapentin is approximately 60%, 47%, 34%, 33%, and 27% following 900 mg, 1200 mg, 2400 mg, 3600 mg, and 4800 mg/day given in 3 divided doses, respectively. Food has only a slight effect on the rate and extent of absorption of gabapentin (14% increase in AUC and Cmax). Dose gradually to 1800 mg/day orally; take once a day with evening meal. Day 1: 300 mg orally once a day. Day 2: 600 mg orally once a day. Days 3-6: 900 mg orally once a day. Days 7-10: 1200 mg orally once a day. Days 11-14: 1500 mg orally once a day. Day 15 and after (maintenance): 1800 mg orally once a day. Dosing considerations: Initial dose: 300 mg orally on day one, 300 mg orally twice a day on day two, then 300 mg orally 3 times a day on day three. Maintenance dose: 900 to 1800 mg orally in 3 divided doses. If necessary, the dose may be increased using 300 mg or 400 mg capsules three times a day up to 1800 mg/day. Gabapentin is used to help control partial seizures (convulsions) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it. Gabapentin is also used to manage a condition called postherpetic neuralgia, which is pain that occurs after shingles. A third study compared gabapentin 900 mg/day, in three divided doses (N=111), and placebo (N=109). An additional gabapentin 1200 mg/day dosage group (N=52) provided dose-response data. A statistically significant difference in responder rate was seen in the gabapentin 900 mg/day group (22%) compared to that in the placebo group (10%). The recommended maintenance dose of gabapentin capsules is 300 mg to 600 mg three times a day. Dosages up to 2,400 mg/day have been well tolerated in long-term clinical studies. Doses of 3,600 mg/day have also been administered to a small number of patients for a relatively short duration, and have been well tolerated. Initial doses are usually around 300-400 mg, while follow up doses may be around 600-800 mg. Doses for this condition should not exceed 2400 mg for regular use and 3600 mg for short term use. Children ages 3-12 using Gabapentin to treat epilepsy will be given 10-15 mg per day in divided doses. This may be increased to 25-35 mg per day as necessary.
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