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Though an off-label use, gabapentin has also been found useful in treating certain mental health disorders. 3 So, during addiction treatment, a person could be prescribed gabapentin to help with symptoms of cannabis, opioid, or alcohol use disorders or to help with co-occurring mental disorders such as anxiety, post-traumatic stress disorder Gabapentin is not likely to cause addiction, but it may lead to dependence or misuse under certain conditions. As such, doctors prescribe gabapentin carefully to avoid withdrawal Recognizing and addressing Gabapentin addiction early is necessary for reducing its long-term effects and increasing the chances of successful recovery. Addiction to Gabapentin adversely affects physical and psychological health, and delaying treatment usually worsens these challenges. Health professionals and prescribers should be aware of the risk for misuse of pregabalin and gabapentin, which eventually could lead to abuse, substance dependence, and intoxications. There have been numerous documented cases of gabapentin abuse, dependence, and withdrawal. Even though gabapentin is sometimes considered as a treatment option for alcohol and substance abuse, it is important to monitor for drug-seeking behaviors. A history of alcohol or substance abuse appears to b Gabapentin is one of the recommended mainstays of evidence-based treatment. 3. Unfortunately, our clinical experience suggests that gabapentin is now prevalent as a drug of abuse. The drug’s effects vary with the user, dosage, past experience, psychiatric history, and expectations. Gabapentin misuse was not observed in AUD studies, 2,4,5,16 but evidence indicates that patients with opioid use disorder, prisoners, and polydrug users are at high risk for gabapentin misuse. 39–41 In all cases, clinicians should monitor for red flags that may indicate abuse, such as missed appointments, early refill requests, demands for The gabapentinoid drugs, gabapentin and pregabalin, are first-line treatments for neuropathic pain. The epidemics of chronic pain and opioid misuse have given rise to the widespread use of non-opioid drugs such as the gabapentinoids for treatment. Unfortunately, the widespread use of gabapentinoid drugs has resulted in reports of misuse and abuse. When taken as prescribed for an intended medical condition, gabapentin is well-tolerated and not considered addictive. However, addiction can occur or worsen when misused illicitly, at higher doses, or combined with opioids. When gabapentin is taken alone and as prescribed, there is little potential for abuse or addiction. However, when a person takes gabapentin with other medications—such as muscle relaxants, opioids, or anxiety medications—it can produce a high. The effects of gabapentin intoxication have been variously described as: 4. Relaxation/sense of calm. In the last ten years, gabapentin and pregabalin have been becoming dispensed broadly and sold on black markets, thereby, exposing millions to potential side-effects. Meanwhile, several pharmacovigilance-databases have warned for potential abuse liabilities and overdose fatalities in association wit Signs and Symptoms of Gabapentin Addiction. Gabapentin addiction can cause behavioral changes similar to those of opioid addiction. These include: 12. Compulsive use of gabapentin despite adverse consequences; Experiencing cravings for gabapentin and increasing the dose without a doctor's recommendation In a subsequent national (US) assessment of medical harm resulting from gabapentin and opioid co-abuse, ~24% of patients with sustained co-prescription of gabapentin and opioids had at least three prescription claims exceeding established dosage thresholds; as compared to the 3% and 8% of patients prescribed gabapentin or opioids alone These findings illustrate the lack of clarity about the efficacy of administration of gabapentin in treatment settings. Additional research about how to best use gabapentin, for whom it may be beneficial, and the effect of prescribed gabapentin on addiction recovery is needed. Keywords: Gabapentin, substance abuse treatment, qualitative, misuse. 1. While there is some evidence for its off-label efficacy in managing several health conditions, including the management of alcohol withdrawal and opioid addiction, gabapentin itself has misuse potential, which can in some cases lead to significantly adverse associated health issues. 1. Gabapentin addiction is caused by its misuse for recreational purposes or to enhance the effects of other substances. Risk factors include a history of substance abuse, mental health disorders, and chronic pain conditions. The drug’s availability and perceived safety also contribute to its misuse. Gabapentin has been increasingly associated with drug abuse, particularly in people who mix it with opioids, alcohol or other substances. Illegal diversion of gabapentin has led to its illicit availability on the streets, as well. Using gabapentin with opioids can be dangerous. Gabapentin, an anticonvulsant medication, is generally considered to have a low risk profile for addiction, but some people may still misuse and abuse it to get high. Chronic gabapentin abuse can increase the risk of developing a gabapentin addiction. There was little evidence of gabapentin abuse among those with a positive history of alcohol abuse or dependence. In fact, Wilens and colleagues (2015) conducted a survey among opioid dependent individuals seeking substance detoxification in the US and found no gabapentin abuse among those undergoing alcohol detoxification . There are actions psychiatrists can take to reduce the use of gabapentin: Educate patients: Engaging in open and honest discussions with patients about the risks and benefits of gabapentin is essential. Patients should be made aware of the potential for abuse, dependence, and overdose.
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