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While previous studies have focused on gabapentin use with opioids, our finding that the odds of substance-related overdose was especially high among GABA+BZD users suggests that gabapentin and benzodiazepine users are also a high-risk group who are potentially also susceptible to adverse outcomes. cases. More research is necessary to establish effective dosing of gabapentin as well as if certain populations, such as patients with a reduced creatinine clearance, would still benefit with gabapentin over solitary use of benzodiazepines. Keywords: gabapentin, benzodiazepines, alcohol withdrawal syndrome Chronic use of a benzodiazepine can cause physiologic dependence and the potential for a withdrawal syndrome upon rapid discontinuation. Benzodiazepine dependance can develop from use of prescribed, illicit (ie, non-prescribed use of compounds used medically), and designer (ie, compounds not used medically) agents. Gabapentin and Xanax (alprazolam) are used to treat anxiety. Gabapentin is primarily an anti-seizure (anticonvulsant) drug used also used for treating post-herpetic neuralgia, the pain that follows an episode of shingles. Xanax belongs to a different drug class called benzodiazepines, and is used to treat anxiety disorders and panic attacks. The continuation of gabapentin after alcohol withdrawal appears to be safe during early sobriety and may aid in reducing alcohol-related cravings or returning to alcohol consumption. Use of a gabapentin-based, benzodiazepine-sparing protool began in early 2015 by the Mayo Clinic, Rochester, Consultation-Liaison Psychiatry Service. That same study also found that gabapentin is prescribed along with one or more central nervous system depressant medications 60% of the time, with opioids and benzodiazepines being in the top three. Pharmacology. While benzodiazepines and other sedative-hypnotics typically act as ligands at GABA receptors, gabapentin (despite its name) does not. No, Gabapentin is not a Benzodiazepine drug. Gabapentin is an anticonvulsant medication used to treat various types of nerve pain and to reduce seizure frequency in people with epilepsy. It has been used to treat anxiety, post-traumatic stress disorder, and to help with alcohol withdrawal. Gabapentin utilization is common among opioid and/or benzodiazepine users. 11-20 While only FDA approved for partial seizures and post-herpetic neuralgia, gabapentin has become an essential component of several multimodal pain management strategies utilized by physicians. 11, 12 Not only that, gabapentin is also prescribed for the management of Abstract. Background and Objectives: Gabapentin has shown promise as a potential agent for the treatment of alcohol withdrawal syndrome. We aimed to evaluate the effectiveness of gabapentin as a benzodiazepine-sparing agent in patients undergoing alcohol withdrawal treatment in all the hospitals of a large tertiary healthcare system. The question of the risk of prescribing a benzodiazepine and inadvertently inducing a substance use disorder is a complicated issue. The older literature on the addiction propensity of benzodiazepines seemed reassuring in suggesting that these drugs were not strong reinforcers and were less likely than others to be the preferred drug of misuse Benzodiazepines (also called “benzos”) are a class of agents that work in the central nervous system and are used for a variety of medical conditions. They act on specific receptors in the brain, called gamma-aminobutyric acid-A (GABA-A) receptors. Several features of the order set revision may have resulted in reduced benzodiazepine exposure including conversion to symptom-triggered benzodiazepine dosing, use of adjunctive therapies to prevent alcohol withdrawal symptoms, and raising the CIWA-Ar threshold at which benzodiazepines should be administered. Future analyses may be able to We aimed to evaluate the effectiveness of gabapentin as a benzodiazepine-sparing agent in patients undergoing alcohol withdrawal treatment in all the hospitals of a large tertiary healthcare system. The combination of gabapentin and benzodiazepine can be safe in the treatment of benzodiazepine withdrawal, according to data presented at American Psychiatric Association annual meeting, We must first understand what Gabapentin is and how it relates to benzodiazepines. What Is Gabapentin? Gabapentin — in the form of tablets, capsules, and oral solutions — is commonly prescribed to help control different types of seizures, especially for those suffering from epilepsy. Understanding Xanax and Gabapentin. Xanax and Gabapentin are both prescription medications that serve distinct purposes: Xanax belongs to a class of medications known as benzodiazepines. It is primarily prescribed for the treatment of anxiety disorders and panic attacks. Gabapentin has growing evidence to support its use in the treatment of alcohol use disorder, however there is limited evidence regarding its role in the treatment of alcohol withdrawal. The purpose of this study was to determine if adjunctive gabapentin reduces the need for benzodiazepine (BZD) administration during alcohol withdrawal. Gabapentin, an anxiolytic drug that is also used off-label to treat alcohol withdrawal, is a potential candidate for modulating benzodiazepine withdrawal. While benzodiazepines and other sedative-hypnotics typically act as ligands at GABA receptors, gabapentin (despite its name) does not. Gabapentin inhibits voltage-gated calcium channels, reducing excitatory neurotransmitter release and thereby producing sedating effects. Coprescribing of benzodiazepines or gabapentinoids (e.g., gabapentin, pregabalin) with opioids is increasingly used in the multimodal treatment of acute and chronic pain, despite limited
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