It is important to recognize this adverse effect because gabapentin is used in conditions like diabetic neuropathy, which is associated with multiple co-morbidities that can give rise to bilateral leg swelling. Presence of gabapentin induced leg swelling can thus confound the clinical picture. Keywords: Edema, gabapentin, lower extremity I know it has to be extremely difficult and frustrating for you and your daughter when something that is supposed to help you like gabapentin causes another problem. I have swelling in my legs caused by lymphedema and have to wear compression socks but mine was not caused by a medication. 4 Answers - Posted in: fluid retention, gabapentin, drug - Answer: Yes,. Swelling will go away after using for awhile. My feet were swollen Can gabapentin cause edema? Yes, gabapentin has been associated with the development of edema in some individuals. Edema is the medical term for swelling caused by the accumulation of fluid in the body's tissues. This study helps us to admit the point that switching brand of gabapentin could cause new side-effects. It is necessary that the physicians know the side-effects of drugs such as gabapentin and notice that an anti-analgesic drug can cause pain too. Distinguish of drug side-effects can prevent of lab tests of unnecessary. Gabapentin can cause changes in kidney function or fluid balance in the body. When the body retains excess fluid, it can lead to noticeable swelling in areas like the legs, ankles, or hands. In rare cases, swelling may result from an allergic reaction to gabapentin. Edema is a well-described side effect of gabapentinoid drugs (i.e., gabapentin and pregabalin). In this study from Ontario, Canada, researchers used provincial databases to examine whether gabapentinoid use was followed by diuretic prescriptions — a so-called “prescribing cascade” in which a drug is prescribed to treat an adverse effect of another drug. Gabapentin is fairly safe when you use it correctly. It does come with some possible side effects, though. People who misuse this drug are also at risk of additional side effects. Gabapentin More rarely, gabapentin can cause fluid buildup (edema), weight gain, and vision problems. It can also cause diarrhea. More serious (but rare) side effects include suicidal thoughts or behavior, and mood changes in children. Although gabapentin is generally well tolerated, 1 potential reported adverse effect is peripheral edema. However, due to the extensive number of etiologies of peripheral edema, medication causes may be overlooked on an inpatient psychiatric unit. Does gabapentin cause water retention in the legs? Yes, gabapentin is associated with peripheral edema , leading to fluid retention and swelling in the legs and feet. The risk is generally considered dose-related and more common in elderly patients. Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Patients taking Neurontin may experience swelling in the feet and ankles. The presence of lower leg swelling may cause discomfort and impair walking. My mother-in-law was unable to wear regular shoes because of swelling of her feet and ankles, so we found her socks and soft slippers that fit her feet comfortably. Similarly, the incidence of peripheral edema caused by CCB is dose related and common in the elderly, comparable to reports of gabapentin induced edema. This case illustrates that gabapentin induced leg swelling can confound the clinical picture and it is thus important to recognize this side effect of gabapentin. Although the mechanism behind peripheral edema from gabapentin is largely unknown, it has been theorized to be similar to the mechanism in which other calcium channel blockers (eg, amlodipine) cause peripheral edema. 6,7 This relationship has been hypothesized to be due to gabapentin's actions on presynaptic voltage-gated calcium channels. 1,6 Does amlodipine cause weight gain? Weight gain has been reported by some people taking amlodipine but this is not a common side effect and some people have also reported weight loss. Weight gain with amlodipine may also be a symptom of edema, which is when you retain fluid, which may be particularly noticeable around your ankles or lower legs. Amlodipine (Norvasc), gabapentin (Neurontin, Horizant, Gralise), and pregabalin (Lyrica) can cause puffy legs and ankles. Birth control pills, certain over-the-counter pain medications, and steroids are a few other culprits. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Related studies Foot, leg, and ankle swelling in Gabapentin; How the study uses the data? The study is based on gabapentin (the active ingredients of Gabapentin). Other drugs that have the same active ingredients (e.g These common side effects of gabapentin may happen in more than 1 in 100 people. They're usually mild and go away by themselves. There are things you can do to help cope with them: As your body gets used to gabapentin, these side effects should wear off. In reply to @sophie46 "I had swollen legs and feet when I was prescribed Gabapentin." + (show) I was also on Paxlovid for COVID and I have Stage II renal failure. Paxlovid has a drastic effect on kidney function and I gained about 20 lbs in less than two weeks.
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