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Research presented at the annual meeting of the North American Menopause Society (NAMS) indicates that an investigational extended release (ER) formulation of gabapentin (Serada, Depomed) is effective for the treatment of hot flashes and sleep disturbance. There are several good quality clinical trials that address gabapentin for hot flashes and it has even been the subject of a recent meta-analysis. In studies, gabapentin reduced hot flashes from 45%-71% depending on the dose. To be included in the meta-analysis, RCTs had to compare gabapentin with placebo in the treatment of hot flashes in women with natural or tamoxifen-induced menopause, regardless of the sample size, dosage used, duration of treatment, or frequency of the episodes. Uncontrolled and openlabel trials were reviewed but excluded from the meta-analysis. Finally, all 3 patients' nighttime awakenings resolved with a single bedtime dose of gabapentin, a therapy known to be an effective treatment for hot flashes and night sweats. 5 – 7 The fact that the nighttime awakenings in Case 1 failed to respond to oral contraception drugs (OCDs) may have been due to the much lower estrogen dose found in Evidence from several randomized controlled trials supports the effectiveness of oxybutynin in treating hot flashes, showing reduction in hot flash frequency by up to 70% to 86%. Oxybutynin is an effective treatment for overactive bladder symptoms, which can increase in hypoestrogenic states. Gabapentin can be considered effective in the treatment of hot flashes and should be considered a reasonable alternative when estrogen therapy is not desired. Hot flashes occur frequently in menopausal women and in women with breast cancer, diminishing their quality of life. earched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used: “menopause,” “hot flushes,” “vasomotor symptoms,” “gabapentin,” and “non-hormonal therapy.” Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and Gabapentin was associated with reductions in the severity and frequency of hot flashes in menopausal women, but there was substantial variation in the results across the included trials. The authors' conclusions appear to be reliable based on the evidence presented. Gabapentin is an antiseizure medication that some people use for hot flashes. While the FDA has not approved this medication for hot flashes, it is an effective option for some individuals. Gabapentin presents a promising option for managing hot flashes, particularly for those who haven’t found relief through other treatments. By understanding its benefits, potential side effects, and proper administration, you can make informed decisions about its use. Gabapentin 300 mg/day could be useful to relieve hot flashes in women for whom hormone therapy is not suitable or when hot flashes do not respond to other therapies. Further researches are needed to determine the efficacy of gabapentin use for longer periods or at higher doses. Objective: Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gabapentin for treating menopausal hot flushes via a meta-analysis. Keywords: hot flashes, men, prostate cancer, gabapentin. Background. Hot flashes are a problematic issue for many men diagnosed with prostate cancer, affecting up to 75% of those on medical or surgical androgen deprivation therapy 1,2. Although a double-blind placebo-controlled clinical trial should be conducted to better elucidate the efficacy and toxicity of gabapentin in patients with hot flashes, the available data suggest that gabapentin is a reasonable treatment to consider in patients with hot flashes if they do not wish to use hormonal therapy. Other prescription medicines. Other medicines that might offer relief for some people include: Gabapentin (Neurontin, Gralise, others). This antiseizure medicine helps ease hot flashes. Does Gabapentin (Neurontin) Treat Hot Flashes? Gabapentin (Neurontin) has emerged as an effective non-hormonal treatment for menopausal hot flashes, with doses ranging from 600 to 2400 mg/day showing significant reduction in both frequency and severity. Fortunately, a new treatment option may be able to treat hot flashes without the risk. Gabapentin, an anticonvulsant, may be effective for the treatment of hot flashes. Often sold as Neurontin, gabapentin is approved by the Food and Drug Administration (FDA) for the treatment of epilepsy. Conclusion. Women who suffer from hot flashes but who cannot or will not take hormone therapy can be offered nonhormonal therapies. Nonpharmacological therapies, such as acupuncture, soy, vitamin E, black cohosh, (which have not been proven to be any more efficacious than placebo), or pharmacological therapies, such as SSRI, SNRI, clonidine, or gabapentin, either IR or ER – all have gabapentin (up to 2400mg per day) have been used.3 How long does it take to work? Generally hot flushes will reduce once 900mg daily dose is reached. Use of 900mg daily has been found to be effective in reducing menopausal hot flushes for at least 5The length of treatment depends on your response to the medicine. Gabapentin is effective in the control of hot flashes at a dose of 900 mg/day, but not at a dose of 300 mg/day. This drug should be considered for treatment of hot flashes in women with breast cancer.
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