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Chronic migraines are less common (1% to 5% of patients with migraines) and are defined as having headaches at least 15 times a month for at least three months. 3 Limited data guide treatment for Talk to your doctor about preventive treatment for your migraines if: You get 1 or more attacks a week; You use rescue medications a lot; Your attacks keep you from work or school; A 2016 study found that gabapentin showed some benefits for migraine headaches. However, it concluded that there wasn't enough evidence to recommend it as a primary therapy. Another study review in 2023 found that gabapentin was no more effective than a placebo in reducing monthly migraine days. Does gabapentin (Neurontin) help prevent episodic migraine? Gabapentin does not decrease the frequency of migraine headaches and is not recommended for prophylactic therapy. (Strength of Despite the conflicting evidence surrounding select studies, a significant amount of evidence shows that GBP has benefit for a majority of primary headache syndromes, including chronic daily headaches. GBP has some efficacy in migraine headache, but not sufficient evidence to suggest primary therapy. Weighing Patient Preferences for Episodic Migraine Treatment. the anticonvulsants gabapentin, lamotrigine, and valproate-topiramate; or; any calcium-channel blockers. Objective: Gabapentin (GBP), originally an antiepileptic drug, is more commonly used in the treatment of pain, including headache disorders. Off-label GBP is used in headache disorders with some success, some failure, and much debate. Gabapentin is used "off-label" for migraine prevention and treatment, including migraines with or without aura, vestibular migraines. It reduces the frequency of headaches, pain intensity, and the use of symptomatic medications 1 , 2 . One trial each of gabapentin 900 mg (53 patients), and gabapentin titrated to 1200 mg (63 patients) and 1800 mg (122 patients) failed to show a statistically significant reduction in headache frequency in the active treatment group as compared to the placebo group, whereas one trial of gabapentin titrated to 1800 to 2400 mg (113 patients Previous experiments have focused on the use of gabapentin for the prevention and treatment of migraine; however, little evidence is available on the effect of the drug on central sensitization during migraine attack or its effect on excitatory amino acids and protein kinase C. The anti-seizure medicines gabapentin (Gralise, Horizant, Neurontin) and topiramate (Topamax, Qsymia, others) may help prevent headache pain. But more study is needed to understand how well they work to prevent tension-type headaches. The muscle relaxant tizanidine (Zanaflex) also can be used for prevention. The results validate current guideline recommendations for treating migraines, which rank triptans as a first-line choice. "If you had asked me to sit down and make a list of the most helpful migraine medications, it would be very similar to what this study found," she says. What else did the study show about migraine pain relievers? Gabapentin is an effective prophylactic agent for patients with migraine. In addition, gabapentin appears generally well tolerated with mild to moderate somnolence and dizziness. Gabapentin is an anticonvulsant used off-label to help prevent migraine attacks. Learn about why it’s used and how it works. Topiramate (Topamax) decreases migraine frequency, and can treat alcohol use disorders, obesity, and post-traumatic stress. Gabapentin (Neurontin) is minimally effective at high doses, and Gabapentin is not a first-line drug for treating migraine, so your provider won’t prescribe it to you unless you’ve tried other preventive medications like antidepressants, beta-blockers, and/or migraine-specific preventative drugs that block calcitonin gene-related peptide (CGRP), including Aimovig, Ajovy, Vyepti, Nurtec, Qulipta, and After 4-week baseline, subjects, aged 18 to 65, were randomized to GPT 2,400 mg/day or placebo. There was 2 weeks titration, 6-week stable dosage, and 1 week washout period between treatment arms. The primary efficacy measure was the difference between the percentage of headache-free days per treatment period. This review considers the evidence for the efficacy and tolerability of the antiepileptic drugs gabapentin and pregabalin for preventing episodic migraine in adults. The prophylactic treatment of migraine in children is the subject of a separate Cochrane review (Victor 2003). The research behind gabapentin for migraine is a bit mixed, but does show some promise. The American Academy of Neurology (AAN) released a statement in 2013 which said there was insufficient evidence supporting gabapentin for migraine prophylaxis. Gabapentin has an average rating of 7.9 out of 10 from a total of 111 reviews for the off-label treatment of Migraine. 78% of reviewers reported a positive experience, while 13% reported a negative experience.
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