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Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. However, the relation between gabapentin initiation and longer-term neurocognitive changes is not well understood. The results revealed that the risk of dementia associated with gabapentin or pregabalin exposure was significant in all subgroups except for the strata having depression or head injury. The risk of dementia development was higher in the younger group (age <50 years) than that in the older group. Gabapentin initiation was not statistically associated with decline on CDR ® GLOB, CDR ® SB, FAQ sum, or mean FAQ at the index + 1 or index + 2 visits. However, gabapentin initiation was significantly associated with increased odds of new falls at the index + 2 visit (odds ratio [95% confidence interval] 2.5 [1.3, 4.6]). Gabapentin use has been associated with memory loss and cognitive decline. Studies suggest that the risk of dementia may be higher in patients treated with gabapentin. It is important for patients and healthcare providers to be aware of the potential cognitive side effects of gabapentin. The multivariate-adjusted hazard ratio of risk of dementia for gabapentin or pregabalin exposure versus the matched non-exposed group was 1.45 (95% confidence interval [CI], 1.36-1.55). The risk of dementia increased with higher cumulative defined daily doses during the follow-up period. Moreover, dementia risk increased along with the cumulative dose. Taking an anticholinergic for the equivalent of three years or more was associated with a 54% higher dementia risk than taking the same dose for three months or less. The University of Washington study is the first to include nonprescription drugs. Certain drugs can worsen dementia symptoms or even increase the risk of developing dementia. Health Conditions Wellness. Tools. Featured. Connect. Subscribe. Explore more in We would like to show you a description here but the site won’t allow us. Evidence suggests that these types of medications could contribute to or worsen dementia. Anticholinergics. This broad category of medications includes drugs we use to treat urinary incontinence, Gabapentin-induced worsening of neuropsychiatric symptoms in dementia with lewy bodies: case reports Most of the data to guide gabapentin use and dosing in older adults is from pharmacokinetic studies or case reports[1,2] While gabapentin is approved to prevent seizures, most patients take gabapentin for reasons of neuropathic pain (71%) or psychiatric disorders, with bipolar being most common (15%), with an average dose of 975 mg per day However, several case reports in which gabapentin was used for agitation in dementia with Lewy bodies question its appropriateness for all types of dementia-related agitation [14–16]. Indeed, paradoxical gabapentin-induced exacerbation of psychosis in a patient with schizophrenia has already been described [ 17 ]. The evidence of gabapentin and dementia is mixed, with two studies looking at hundreds of thousands of people and coming to completely different conclusions. We estimated the yearly prevalence of gabapentin use, both overall and within subgroups defined by cognitive status [normal, mild cognitive impairment, and dementia] and demographics [age and sex] for participants aged 65+. Our analysis suggests that in patients with chronic pain, long-term gabapentin use does not markedly alter dementia risk across varying cumulative dosages, regardless of age or gender. These findings may have significant implications for chronic pain management and underscore the potential cognitive safety of prolonged gabapentin administration. Gabapentin use was significantly associated with decline in cognitive and functional status among older adults with initially normal cognition. Further studies are needed to examine the association. Applying the inclusion and exclusion criteria yielded 201,492 patients for the study: 25,373 in the dementia cohort and 174,930 in the non-dementia cohort. Post 1:1 matching, and after excluding recent gabapentin use (within three months of the index date), the study comprised 22,769 individuals in the dementia cohort and 22,644 in the non-dementia Especially in older adults, gabapentin is prescribed to treat behavioral and psychological symptoms of dementia (BPSD) (Kim et al., 2008). Several studies have reported that gabapentin has a deleterious effect on cognition (Leach et al., 1997; Meador et al., 1999; Shem et al., 2018). The adjusted odds ratio for dementia risk associated with gabapentin use was 0.91 (95 % C.I. 0.83-1.01), indicating no substantial increase in risk. Conclusion: Long-term Gabapentin therapy for chronic pain is not associated with a differential risk of dementia across dosage levels, irrespective of age or gender. Further study into its And since treatment options for dementia are limited, prevention is key. Dementia risk is tied to common things like diabetes, high blood pressure, and physical inactivity. But some common medications are associated with dementia risk, too. Here are four common drug classes linked to dementia, and what the research says about your risk. 1.
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