While gabapentin (Neurontin) and pregabalin (Lyrica) share many similarities, there are a few things that set them apart. We’ll highlight seven key differences between these medications below. 1. Pregabalin is FDA approved for more uses than gabapentin, but both are often used off-label. (1) The first-line treatment for partial epilepsy is carbamazepine monotherapy; gabapentin monotherapy is an alternative, given its lower risk of drug-drug interactions. (2) The standard treatment for neuropathic pain associated with diabetes or post-herpetic neuralgia is a tricyclic antidepressant, with gabapentin as an alternative. Pregabalin is Gabapentin alternatives for epilepsy, nerve pain, and anxiety. Other drugs for nerve pain include topiramate, baclofen, tricyclic antidepressants such as amitriptyline and Dosulepin, and serotonin-norepinephrine reuptake inhibitors such as duloxetine. Gabapentin Alternatives are increasingly sought after by individuals seeking effective treatments for neuropathic pain, seizures, and other related conditions. In 2025, advancements in medical research have introduced a variety of alternatives that cater to different patient needs, preferences, and medical profiles. Drugs like gabapentin and pregabalin, Neurontin, and Lyrica bind these receptors at the alpha-2-delta subunit of the Cav2.2 channel, reducing pain signal transmission. This class of medications is called gabapentinoids, and while these medications are now widely used for nerve pain and epilepsy, as they are the best we have right now, they are More about Neurontin () More about Gabapentin More about Qutenza () Ratings & Reviews: Neurontin has an average rating of 7.3 out of 10 from a total of 195 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 13% reported a negative effect. gabapentin (Neurontin) lamotrigine (Lamictal) pregabalin (Lyrica) SIDE EFFECTS. Dry mouth, sexual dysfunction, dizziness, constipation, blurred vision, and upset stomach. Nausea, dizziness, sweating. Tend to have fewer side effects than tricyclic antidepressants. Drowsiness, dizziness, and nausea. Avoid alcohol when taking these drugs. Compare Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. A range of alternatives to gabapentin that may be effective are available. These include prescription medication options, over-the-counter substitutes, and natural remedies. Gabapentin Alternatives: Many effective substitutes exist for nerve pain relief. Natural Remedies: Options like capsaicin and turmeric can offer pain management. Prescription Options: Medications such as Pregabalin and Amitriptyline may help. Yes, several natural remedies can be effective alternatives to Gabapentin. Options like omega-3 fatty acids , curcumin , and acupuncture have shown promise in alleviating nerve pain. These methods often come with fewer side effects and can be integrated into a holistic treatment approach. 4. If a patient is on 4 AEDs and one of these has no suitable alternative, consider holding this single AED without replacement if clinically appropriate. 6. Parenteral ketogenic diet is possible for hospitalized patients. Contact nutrition support if IV ketogenic diet is desired. LEV None - see Chart A LCM or FOS LZP 10:1 CLB:LZP Generic Researchers publishing in JAMA Neurology describe the results of a unique trial in which 402 people with idiopathic sensory polyneuropathy were randomly assigned to one of four medications: duloxetine, mexiletine, nortriptyline, or pregabalin. Using the 6:1 ratio an equivalent dose of gapapentinoid can be determined using a step-wise approach. Determine total dose (in mg) taken by an individual in a 24-hour period. Divide total daily dose (in mg) of gabapentin by 6 to give total daily dose of pregabalin (in mg). Pregabalin and gabapentin both resulted in moderate to large increases in cognitive effects (4.8%), dizziness (25.6%), and weight gain (10.1%); pregabalin also resulted in large increases in the Gabapentin (Neurontin) Ursprünglich wurde Gabapentin gegen Epilepsie entwickelt. In erster Linie wird es aber inzwischen gegen Neuropathie eingesetzt. In der Regel startet man mit 3x 100mg am Tag, das heißt jeweils morgens, mittags und abends. Anschließend wird in regelmäßigen Abständen die Dosis erhöht. There are a variety of alternative medications available that treat nerve pain and/or seizures. Your doctor will be able to determine the best medication for your specific health needs. If gabapentin does not work for you, or if you believe the side effects are too severe, talk with your doctor to find an alternative medicine to treat nerve Gabapentin and pregabalin are similar drugs but differ in several distinct ways. The main differences are their indications—specific uses that the Food and Drug Administration (FDA) has approved them to treat—and their dosages. If gabapentin does not work for you, or if you believe the side effects are too severe, talk with your doctor to find an alternative medicine to treat nerve pain and/or seizures. Antidepressants Certain antidepressants work to relieve pain.
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