Does Gabapentin raise blood sugar? Can a statin such as atorvastatin cause a rise in blood sugar levels? Updated 26 May 2022 1 answer. Search for questions. Her blood glucose level was 33 mg/dL. Gabapentin was started 1 week prior to the hypoglycemia episode. Her past medical history, concomitant medications, and other laboratory findings were not likely causes of her severe hypoglycemia. Gabapentin is used to control seizures, to treat nerve pain that can happen after having had shingles, and to treat a condition called restless legs syndrome. In addition to these FDA-approved uses, doctors sometimes prescribe gabapentin off-label. Despite adequate pain control achievement following gabapentin initiation, blood glucose values continued to rise. From a search of the medical literature, 2 articles speak to the effect of gabapentin on blood glucose levels. Gabapentin has been associated with both hypoglycemia and hyperglycemia in different patient cases. The drug's interaction with GABA receptors and voltage-gated calcium channels may influence insulin secretion, leading to these varying effects on blood sugar levels. askyourpharm.com Hyperglycemia is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lantus, and have Depression. When considering the use of Gabapentin for diabetics, several potential benefits arise: Pain Relief: Many diabetics suffer from neuropathic pain due to nerve damage caused by high blood sugar levels. Gabapentin can significantly reduce this pain. Improved Sleep: Chronic pain often disrupts sleep patterns. By alleviating discomfort, Gabapentin As evident from the literature, Gabapentin exhibits its effect as an antioxidant and anti-inflammatory agent, the combined effect of which resulted in decreased blood glucose levels; however, it No, gabapentin does not directly cause high blood sugar levels. Current research indicates that there is no significant link between gabapentin use and elevated glucose levels. The medication primarily affects neurotransmitter activity and does not alter insulin function directly. The short answer is: yes, it is possible, though not very common, for gabapentin to raise your blood sugar. Studies have shown that approximately 1.2% of patients treated with gabapentin may experience hyperglycemia (high blood sugar) compared to 0.4% with a placebo. By monitoring blood glucose levels, individuals can also determine how gabapentin is affecting their blood sugar. If significant changes are detected, individuals can consult with their healthcare professional to discuss potential adjustments to their medication or lifestyle choices. A 47-year old, 68 kg, white female presented to the emergency department with altered mental status. Her blood glucose level was 33 mg/dL. Gabapentin was started 1 week prior to the hypoglycemia episode. Her past medical history, concomitant medications, and other laboratory findings were not likely causes of her severe hypoglycemia. CONCLUSIONS: Hypoglycemia is a rarely acknowledged adverse effect of gabapentin overdose and requires urgent intervention as it could be initially resistant to simple glucose replacement and may lead to serious consequences. In this case, blood glucose levels responded only to high concentration dextrose infusion (D10) with concomitant tube feeds. The SmPC of gabapentin mentions blood glucose fluctuations in diabetic patients as a potential adverse drug reaction with unknown frequency [1]. The current observation describes the association between gabapentin and severe hypoglycaemia in diabetic and non-diabetic patients. Reports Hypothetically, gabapentin-induced GABA A receptor activation could stimulate insulin release resulting in hypoglycaemia. Alternatively, direct binding to the alpha 2 -delta 2 receptor of the voltage-gated calcium channels could also provide a pharmacological explanation. High blood sugar is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lantus, and have Depression. The Link Between Gabapentin and Blood Sugar. The mechanism by which gabapentin might influence blood sugar levels isn’t fully understood. However, the slight increase in the risk of hyperglycemia suggests that gabapentin can, in some individuals, affect glucose metabolism. Blood glucose (blood sugar) testing: There are a handful of tests that can help you understand your blood glucose levels. Check out the most common tests for diabetes . Early signs of diabetes: Learn how to recognize the signs and symptoms of diabetes . Ask your doctor to evaluate your blood glucose levels for hypoglycemia. He/she might want to adjust your dose of gabapentin, or send you to a dietician to establish a special diet to control the low blood sugar if your glucose is not dropping too severely.
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