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An interaction with duloxetine could cause a serious condition called serotonin syndrome. Cymbalta is not approved for use by anyone younger than 7 years old. To make sure this medicine is safe for you, tell your doctor if you have: Serotonin syndrome, also referred to as serotonin toxicity, is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system. It is seen with therapeutic medication use, inadvertent interactions between drugs, and intentional self-poisoning . Serotonin syndrome can occur when you increase the dose of certain medications or start taking a new drug. It's most often caused by combining medications that contain serotonin, such as a migraine medication and an antidepressant. Some illicit drugs and dietary supplements are associated with serotonin syndrome. Research has indicated that gabapentin can cause serotonin syndrome, especially when taken with other drugs like tramadol. One study found that a 66-year old man who took a combination of tramadol and gabapentin after spinal surgery experienced serotonin syndrome. 1 While gabapentin does not inherently cause serotonin syndrome, the potential for interactions exists when combined with these medications. Clinical studies have shown no direct link between gabapentin usage and the onset of serotonin syndrome. Duloxetine (Cymbalta) raises the serotonin levels in your brain to help improve mood and pain. Serotonin syndrome is a rare, but potentially life-threatening condition that can happen when there's too much serotonin in the brain. Get medical help right away if you have symptoms of serotonin syndrome, like fast heart rate, sweating, muscle Duloxetine belongs to a group of medicines known as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). These medicines are thought to work by increasing the activity of chemicals called serotonin and norepinephrine in the brain. This medicine is available only with your doctor's prescription. Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. 5. Tips. May be taken with or without food. Cymbalta is a delayed-release product. Swallow Cymbalta capsules whole, do not crush or chew. Find patient medical information for Duloxetine (Cymbalta, Drizalma Sprinkle) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings A potentially lethal condition, serotonin syndrome (SS) is caused most often when certain antidepressant agents are taken concurrently with other drugs that modulate synaptic serotonin levels. 1,2 When patients take two or more antidepressants from different pharmacologic classes, drug-drug interactions may occur; these interactions may lead to Serotonin syndrome is a potentially life-threatening condition that can occur when there is an excess of serotonin in the brain. Symptoms may include agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and coordination problems. Serotonin syndrome: Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), while gabapentin is not known to directly affect serotonin levels. However, there have been rare reports of serotonin syndrome occurring when these medications are taken together. Physicians treating spine patients should be alert about SS in patients using both tramadol and gabapentin. gabapentin (Neurontin) pregabalin Serotonin syndrome is a rare but potentially life threatening condition. For more information on serotonin syndrome, see the “Cymbalta and other drugs Understanding Synergies and Repercussions In the realm of pharmaceuticals, the amalgamation of diverse remedies can yield both fortuitous synergies and unforeseen consequences. Delving into the labyrinth of pharmaceutical interactions unveils a dynamic interplay between substances, where their combined influence can transcend individual efficacy. Navigating the Terrain of Compatibility Duloxetine, sold under the brand name Cymbalta among others, [1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, and central sensitization. We report a case of serotonin syndrome in a patient taking five agents that have known or reported serotonergic association. Symptoms began a year prior and were missed by multiple clinicians despite the addition of more serotonergic agents. Physical examination revealed tremor and provoked myoclonus in both lower extremities. We diagnosed serotonin syndrome, and all serotoninergic medications were stopped. With supportive care, including 2 mg intravenous lorazepam administered every 4 hours, the patient’s symptoms resolved rapidly. Cymbalta is a prescription medicine used to treat symptoms of major depressive disorder, diabetic peripheral neuropathic pain, generalized anxiety disorder, fibromyalgia, and chronic muscle pain. Learn about dosage, side effects, drug interactions, warnings, and others. Gabapentin, an anticonvulsant, is often a first-line treatment for nerve pain. It works by calming overactive nerve signals. On the other hand, Cymbalta (duloxetine), is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), an antidepressant that also helps manage nerve pain by affecting neurotransmitters in the brain.
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