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Gabapentin may improve sleep quality in menopausal women with hot flashes. These results warrant further prospective investigation, with an emphasis on measuring subjective sleep quality and maintenance. The Most Common Sleep-Disrupting Menopause Symptoms There are also non-hormonal meds like off-label gabapentin and paroxetine that can help treat side effects ranging from hot flashes to In recent years, a surprising contender has emerged in the fight against menopause-related sleep issues: gabapentin. Originally developed as an anticonvulsant medication, gabapentin has found its way into the arsenal of treatments for various conditions, including sleep disorders. An investigational nonhormonal drug, extended-release gabapentin, effectively improved sleep and reduced hot flashes in menopausal women. North American Menopause Society. Nonhormonal management of menopause-associated vasomotor symptoms: 2015 position statement of The North American Menopause Society. Menopause. 2015. Pandya KJ, Morrow GR, Roscoe JA, et al. Gabapentin for hot flashes in 420 women with breast cancer: a randomized double blind placebo-controlled trial. Preliminary evidence indicates that gabapentin can attenuate insomnia, bolster sleep quality, and increase total sleep duration. Moreover, gabapentin has been shown to increase slow-wave sleep (SWS), promote sleep maintenance, and decrease unwanted awakenings throughout the night. Clinicians have been using gabapentin off-label to help relieve hot flashes in postmenopausal women. A new extended-release formulation of gabapentin has also shown efficacy in treating hot flashes and improving sleep quality with potentially fewer side effects than regular gabapentin. 12–18. Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. Research presented at the annual meeting of the North American Menopause Society (NAMS) indicates that an investigational extended release (ER) formulation of gabapentin (Serada, Depomed) is effective for the treatment of hot flashes and sleep Yurcheshen et al. demonstrated that gabapentin improved sleep quality in menopausal women with HFs at a dose of 300 mg, three times daily, in a RCT , and positive effects of gabapentin on nighttime awakenings and sleep-enhancing actions were also observed in the hypothesized novel sleep disorder, LUNA, associated with low serum estradiol Discussion. This study revealed that without consideration of the type of sleep outcomes, gabapentin was significantly superior to placebos for the treatment for sleep disorders secondary to RLS, neuropathic pain, alcohol dependence, hot flashes in menopause, fibromyalgia, phantom limb pain, HIV-associated sensory neuropathies, and bipolar disorder. Three cases are presented here suggesting that insomnia due to nighttime awakenings in some cycling premenopausal women may be physiologically related to menopausal night sweats and may also improve with bedtime gabapentin, a treatment known to be effective for hot flashes and night sweats. For those grappling with insomnia, gabapentin’s ability to modulate neurotransmitter activity may help calm an overactive mind, making it easier to fall asleep and stay asleep throughout the night. Menopause and insomnia: What is the link? Medically reviewed by Kendra Kubala, PsyD Menopause can cause symptoms such as hot flashes and night sweats, which make sleep more difficult. isorder is most common associated manifestations. Sleep disorders and insomnia largely remain a clinical diagnosis based on the subjective complaints of patients. Benzodiazepines remain the mainstay of the treatment in majority of the sleep disorders including chronic or acute insomnia. Treatment of associated anxiety, depression, or psychosis is most important. Tricyclic antidepressant Gabapentin 300 mg at bedtime (qhs) was initiated in 9/2006, based on evidence of efficacy in the treatment of hot flashes and night sweats 5 – 7 and improved sleep in such patients. 8 The patient experienced benefit after the first dose of gabapentin, reporting a full night's sleep without any awakenings or night sweats. This degree of Women are likely to suffer from sleep disorders more in comparison to men during menopause and with advancing age. The incidence of sleep disorders ranges from 16% to 47% at peri-menopause and 35%–60% at postmenopause. Insomnia with or without
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