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Moreover, dementia risk increased along with the cumulative dose. Taking an anticholinergic for the equivalent of three years or more was associated with a 54% higher dementia risk than taking the same dose for three months or less. The University of Washington study is the first to include nonprescription drugs. The adjusted odds ratio for dementia risk associated with gabapentin use was 0.91 (95 % C.I. 0.83-1.01), indicating no substantial increase in risk. Conclusion: Long-term Gabapentin therapy for chronic pain is not associated with a differential risk of dementia across dosage levels, irrespective of age or gender. Further study into its There’s mounting evidence supporting a connection between certain medications (anticholinergics and benzodiazepines) and dementia. An expert discusses the latest research and what to do if you The evidence of gabapentin and dementia is mixed, with two studies looking at hundreds of thousands of people and coming to completely different conclusions. Especially in older adults, gabapentin is prescribed to treat behavioral and psychological symptoms of dementia (BPSD) (Kim et al., 2008). Several studies have reported that gabapentin has a deleterious effect on cognition (Leach et al., 1997; Meador et al., 1999; Shem et al., 2018). The results revealed that the risk of dementia associated with gabapentin or pregabalin exposure was significant in all subgroups except for the strata having depression or head injury. The risk of dementia development was higher in the younger group (age <50 years) than that in the older group. However, several case reports in which gabapentin was used for agitation in dementia with Lewy bodies question its appropriateness for all types of dementia-related agitation [14–16]. Indeed, paradoxical gabapentin-induced exacerbation of psychosis in a patient with schizophrenia has already been described . To explore the association between gabapentin use and the risk of dementia in patients with chronic pain, considering the rising concerns of dementia in an aging population and the potential cognitive impacts of chronic pain management. Applying the inclusion and exclusion criteria yielded 201,492 patients for the study: 25,373 in the dementia cohort and 174,930 in the non-dementia cohort. Post 1:1 matching, and after excluding recent gabapentin use (within three months of the index date), the study comprised 22,769 individuals in the dementia cohort and 22,644 in the non-dementia The prevalence of gabapentin use increased from 2006 to 2019, both in overall population and within every subgroup (i.e., cognitive status, age group, and sex). About 10–30% of gabapentin users reported to concurrently use gabapentin with opioids. Over one-half of gabapentin users with dementia concurrently used gabapentin with antidepressants. We conducted this population-based cohort study to understand the risk of acute altered mental status and mortality within 30 days of initiating a high versus low dose of gabapentin in older adults, a segment of the population at higher risk of adverse drug events. Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. However, the relation between gabapentin initiation and longer-term neurocognitive changes is not well understood.
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