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Gabapentin is a prescription drug most commonly prescribed to relieve nerve pain following shingles in adults and the pain of postherpetic neuralgia. Learn about side effects, drug interactions, dosages, warnings, and more. Gabapentin, a medication primarily used to treat seizures and nerve pain, is generally considered safe when used as directed. However, like many medications, it can interact negatively with other substances, leading to unwanted side effects or reduced efficacy. Gabapentin (Neurontin, Gralise, Horizant) is a medicine used to treat partial seizures, nerve pain from shingles and restless leg syndrome. It works on the chemical messengers in your brain and nerves. Gabapentin is from a group of medicines called anticonvulsants. Gabapentin is ineffective in absence seizures and should be used in caution in patients with mixed seizure disorders involving absence seizures. Gabapentin has been associated with drug reaction with eosinophilia and systemic symptoms (DRESS), otherwise known as multi-organ hypersensitivity. When it comes to drug interactions, some might cause harmful side effects, while others can impact gabapentin’s effectiveness. Gabapentin belongs to a group of medications called anti-epileptics . It can be used to treat seizures and nerve pain associated with shingles . Those taking gabapentin should therefore always disclose to their doctors any medical conditions, other medications (prescription or over the counter), supplements, herbal products, illicit drugs, tobacco products, alcoholic beverages, and dietary choices. This way, their doctors can better evaluate the risk of interactions. Drug Interactions Patients should be informed of the potentially fatal risks of interactions between gabapentin and alcohol, and with other medicines that cause CNS depression, particularly opioids. MHRA/CHM advice: Antiepileptic drugs in pregnancy: updated advice following comprehensive safety review (January 2021) Let’s delve deeper into these interactions. Risks of Combining Gabapentin and Hydrocodone (Vicodin®) Hydrocodone, the active component of Vicodin, has considerable pain-relieving properties. However, when used concurrently with Gabapentin, both drugs, known for their sedative properties, can contribute to enhanced CNS depression. Interactions With Other Drugs. If you’re taking gabapentin and Tylenol together, be aware that each one might have interactions with other drugs and medications. Gabapentin and acetaminophen Do not use more than the recommended dose of gabapentin, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns. There are 4 disease interactions with gabapentin. Major Potential Hazard, Moderate plausibility. Applicable conditions: Drug Abuse/Dependence. Anxiolytic, sedative, and hypnotic agents have the potential to cause dependence and abuse. In order to prevent this drug interaction, patients are advised to delay administration of gabapentin to at least 2 hours after taking the antacid. Diagnostic Test Aside from these medications, gabapentin can also cause false positive readings in the patient’s dipstick test for urinary protein. Some of the main substances that interact with gabapentin are morphine, caffeine, losartan, ethacrynic acid, phenytoin, mefloquine and magnesium oxide. Some of the side effects caused by gabapentin are teratogenicity, hypoventilation, respiratory failure and myopathy. Gabapentin drug interactions. There are 270 drug interactions with gabapentin. Gabapentin disease interactions. There are 4 disease interactions with gabapentin which include: drug dependence; renal dysfunction; suicidal tendency; hemodialysis Both Gabapentin and Prochlorperazine have effects on the CNS and can cause sedation, which might affect the ability to perform skilled tasks (see 'Drugs and Driving' in Guidance on Prescribing). In some cases, use of two or more drugs that have effects on the CNS might also increase the risk of CNS depressant effects (which could range from Gabapentin is a drug used to treat certain types of seizures, postherpetic neuralgia, and other nerve pain. It is also used to treat restless legs syndrome. Gabapentin is usually well tolerated, but like all medications, it can interact with other drugs and substances. Are there any serious interactions with gabapentin and other medications? Serious breathing problems can happen if you take gabapentin with drugs that cause severe sleepiness or decreased awareness. Some examples include narcotic opioids, anti-anxiety medicines, antidepressants, and antihistamines. Gabapentin is commonly used to treat and prevent seizures in people with epilepsy or to treat nerve pain (postherpetic neuralgia) that can occur after a viral infection called shingles.
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