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Chronic pruritus is a distressing symptom that is often refractory to treatment. Patients frequently fail topical therapies and oral over-the-counter antihistamines, prompting the clinician to consider alternative therapies such as neuroactive agents. Herein, the use of gabapentin and pregabalin, 2 medications well known for treating neuropathic pain and epilepsy that are occasionally used for The novel antiepileptic drugs pregabalin and gabapentin demonstrated significant therapeutic value in the treatment of pruritus, with a favorable safety profile. Compared to commonly used pruritus treatments such as antihistamines and antidepressants, these medications offered a promising alternativ Pregabalin and gabapentin seem to be effective for chronic pruritus, and there is limited data comparing pregabalin and gabapentin 4. However, pregabalin has some advantages over gabapentin, such Efficacy and safety of pregabalin versus gabapentin among chronic pruritus patients: a randomized study Gabapentin is a well-established treatment option for itch with a reassuring safety profile that does not require continued lab monitoring. Generalized itching is a common cause of visits to the dermatologist and can be difficult to treat, leading to sleepless nights and inability to function. Gabapentin and pregabalin were initially developed as antiepileptics, but are now also used for treating neuropathic pain such as that caused by diabetic neuropathy and postherpetic neuralgia. 17, 18 Among the array of agents that can be used for these indications, gabapentin is favored because of its low adverse-effect profile, broad therapeutic index, absence of drug-drug interactions There is currently no standardized algorithm for the treatment of chronic pruritus (CP), or itch lasting more than 6 weeks, in adults aged ≥ 65 years. The antiepileptic agents gabapentin and pregabalin, however, are gaining popularity in the dermatologic community for their efficacy in treating CP of neuropathic origin. Clinicians should consider prescribing pregabalin and gabapentin for pruritus, potentially replacing conventional treatments while refining dosing strategies and monitoring patient safety based on the reported outcomes. The novel antiepileptic drugs pregabalin and gabapentin demonstrated significant therapeutic value in the treatment of pruritus, with a favorable safety profile. Compared to commonly used pruritus treatments such as antihistamines the use of gabapentin and pregabalin as antipruritic agents are explored. They are found to be promising alternative treatments for the relief of several forms of chronic pruritus, particularly uremic Gabapentin and pregabalin are safe and efficacious options to treat older adults with chronic pruritus. Prior to gabapentinoid initiation, the patient should be screened for: history of kidney disease; COPD or other lung disorders; current opioid medication use; history of falls, lightheadedness, or vertigo; history of mood disorders, including The maximum recommended dose is 3600 mg per day for gabapentin and 600 mg per day for pregabalin. 6 Gabapentin is a preferred drug in view of its low adverse effect profile, broad therapeutic Patients were randomly divided into two groups (Group A and B), with Group A receiving pregabalin 25 mg and Group B receiving gabapentin 100 mg. The efficacy and safety of drugs were assessed after 6 weeks using visual analog scale and 5D itch scale. Multiple studies have demonstrated that gabapentin and pregabalin are effective for several forms of pruritus, in particular uremic pruritus and that of neural origin. Gabapentin and pregabalin are promising therapeutic options for pruritus refractory to conventional treatment. In patients with CKD and itching that persists despite attempts to correct calcium and phosphate balance and treatment with emollient creams, we have demonstrated that both gabapentin 100 mg and pregabalin 25 mg improve pruritus in dialysis patients compared with baseline (no therapy). Herein, the use of gabapentin and pregabalin, 2 medications well known for treating neuropathic pain and epilepsy that are occasionally used for relieving chronic pruritus is explored. The findings from original sources published to date to evaluate the use of gabapentin and pregabalin as antipruritic agents are explored. There is currently no standardized algorithm for the treatment of chronic pruritus (CP), or itch lasting more than 6 weeks, in adults aged ≥ 65 years. The antiepileptic agents gabapentin and pregabalin, however, are gaining popularity in the dermatologic community for their efficacy in treating CP of neuropathic origin. Yet the lack of literature specifically looking at the safety and Pregabalin is a new anticonvulsant that is licensed for the treatment of neuropathic pain in adult patients. 2 The similar drug gabapentin has been used occasionally in patients with chronic pruritus, which encouraged us to apply pregabalin as a new therapeutic alternative. 3 Pregabalin treatment should be monitored by regular laboratory testing (liver, kidney function, blood cell counts) and The gabapentinoids gabapentin and pregabalin inhibit voltage-gated calcium channels at the DRG and dorsal horn, likely reducing central pruritoception and neural excitation by itch stimuli.96 Controlled trials have shown their effectiveness for uremic pruritus, but their use in neuropathic itch is limited to case reports.97-99 Gabapentinoids are also a therapeutic option for CPUO without Th2
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