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What are the contraindications of Gabapentin (Neurontin)? The contraindications of gabapentin (Neurontin) are: Caution: pregnancy, lactation, children <3yr, older patients, renal and hepatic impairment, hemodialysis, suicidal thoughts, depression. Gabapentin (Neurontin) Interactions. Gabapentin (Neurontin) interactions include: Pain Management: Gabapentin Page 2 _____6. Which of the following patients is at highest risk for serious adverse effects of Neurontin: A. 32-year old nursing mother B. 60-year old woman with hypertension C. 75-year old man with emphysema D. 49-year old man who is immunocompromised _____7. Abrupt discontinuation of Neurontin is likely to cause: Mechanism of action is not known. May affect transport of amino acids across and stabilize neuronal membranes. Therapeutic Effects: Decreased incidence of seizures. Decreased postherpetic pain. Neurontin (gabapentin) is used to treat pain you may have from shingles (postherpetic nerve pain). It is also used with other seizure medicines for partial onset seizures in patients 3 years and older. Gralise (gabapentin) is only used for pain after having shingles (postherpetic nerve pain). It should not be used for any other medical condition. Here are other nursing pharmacology study guides: Nursing Pharmacology – Study Guide for Nurses Our collection of topics related to nursing pharmacology; Pharmacology Nursing Mnemonics & Tips These nursing mnemonics aim to simplify the concepts of pharmacology through the use of a simple, concise guide. Generic Drug Name Stems Cheat Sheet Precautions and contraindications: Available preparations: Capsules, oral solution, tablets, extended-release tablets (Horizant) Dosages for adults: For treatment of partial seizures: 900-1800 mg/day. For postherpetic neuralgia: 300-1800 mg/day. For moderate to severe primary restless legs syndrome (Horizant): 600 mg PO in the evening. Nursing Considerations Therapeutic Effects Side/Adverse Effects; Anticonvulsant: gabapentin: Administer first dose at bedtime to decrease dizziness and drowsiness Monitor for worsening depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior Taper dose; do not stop abruptly: Decreased neuropathic pain or seizures Generic Name Gabapentin DrugBank Accession Number DB00996 Background. Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid that was first approved for use in the United States in 1993. 16 It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures 14,5 - today it is also widely used to treat neuropathic pain. 8 Contraindications. Hypersensitivity. Lactation. Nursing considerations Assessment. History: Hypersensitivity to gabapentin; lactation, pregnancy; Physical: Weight; T; skin color, lesions; orientation, affect, reflexes; P; R, adventitious sounds; bowel sounds, normal output; Interventions. Give drug with food to prevent GI upset. Point of Care - Clinical decision support for Gabapentin. Treatment and management. Indications, Mechanism of Action, Administration, Adverse Effects, Contraindications, Monitoring, Toxicity, Enhancing Healthcare Team Outcomes Gabapentin administration requires meticulous nursing care. Nurses ensure proper medication administration, closely monitor side effects such as drowsiness and dizziness, and assess for drug interactions. Find information on Gabapentin (Gralise, Horizant) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF. Gabapentin Nursing Considerations and implications. Learn monitoring, administration, and patient education for safe and effective therapy. Screen patients for risk factors and contraindications before initiating gabapentin therapy, such as renal impairment, history of substance misuse, or concurrent medication interactions. Apply patient-centered approaches to gabapentin prescribing, tailoring dosage adjustments and treatment plans based on individual needs and preferences. Gabapentin is in a class of medications called anticonvulsants. What are the brand names of gabapentin? Gabapentin is available as both a brand name product and a generic product (chemically the same, usually lower cost than the brand name product). Brand names of gabapentin include Horizant®, Gralise® and Neurontin®. Precautions and Contraindications. Before taking gabapentin, it is important to be aware of the following precautions and contraindications: 1. Allergy. Individuals with a known allergy or hypersensitivity to gabapentin should avoid its use. 2. Kidney problems. Gabapentin is primarily eliminated from the body through the kidneys. Advise patient not to take gabapentin within 2 hr of an antacid. Gabapentin may cause dizziness and drowsiness. Caution patient to avoid driving or activities requiring alertness until response to medication is known. Seizure patients should not resume driving until physician gives clearance based on control of seizure disorder. 3 days. The recommended maintenance dose of NEURONTIN in patients 3 to 4 years of age is 40 mg/kg/day, given in three divided doses. The recommended maintenance dose of NEURONTIN in patients 5 to 11 years of age is 25 mg/kg/day to 35 mg/kg/day, given in three divided doses. NEURONTIN may be administered as the oral solution, capsule, or tablet, or Contraindications : Gabapentin is contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients and avoid abrupt withdrawal. Reduce dose in renal impairment. Dosing : ANTIEPILEPTICS, PART 2: DRUG NAME: vigabatrin (Sabril) gabapentin (Neurontin, Gralise) CLASS: GABA inhibitors: GABA analogues: MECHANISM OF ACTION: Prevent GABA reuptake into presynaptic neurons; ↑ GABA concentration in synapse; ↓ seizure activity
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