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This report addresses dose-dependent gabapentin-induced sexual dysfunction reaching total sexual dysfunction (loss of libido, anejaculation, anorgasmia, and impotence) at a total daily dose of only 300 mg. It also has off-label uses for the treatment of generalized anxiety disorders, fibromyalgia, and tension headache and prevention of migraine. Few cases were reported with sexual dysfunctions (SDs) as adverse effects of PGB and gabapentin, and the majority were dose related (≥900 mg/d for gabapentin). In men, Gabapentin is associated with sexual dysfunction. Men who use the medication have a high incidence of anorgasmia or difficulty in achieving an orgasm. Gabapentin-induced sexual dysfunction is common in older men. When to See a Doctor. When your doctor prescribes Gabapentin they should advise you about the side effects. Researchers have found that men taking gabapentin (trade name Neurontin) -- a medication commonly used to treat neuropathic pain, seizures and bipolar disease in older and elderly patients Indeed, their psychiatric patient experienced loss of libido, anejaculation/anorgasmia, and erectile dysfunction when treated with gabapentin (GBP) at a daily dose of 300 mg, demonstrating how even very low doses of new antiepileptic drugs can cause SD in predisposed individuals. But it’s unclear how likely gabapentin is to cause sexual side effects like erectile dysfunction. This is partly because erectile dysfunction can occur for several reasons, including many health conditions and other medications. This report addresses dose-dependent gabapentin-induced sexual dysfunction reaching total sexual dysfunction (loss of libido, anejaculation, anorgasmia, and impotence) at a total daily dose of only 300 mg. Research on gabapentin sexual side effects is ongoing, but the research that has been done shows that the drug may produce different symptoms in men and women. One specific study conducted by Rutgers University found that gabapentin can actually reduce painful sex during intercourse and increase sexual desire in women. 1 Low-dose gabapentin may result in marked sexual dysfunction, including loss of libido, erectile dysfunction, ejaculatory dysfunction, and anorgasmia. Such sexual dysfunction may lead to medication noncompliance. Patients often do not volunteer information regarding sexual dysfunction, and therefore, targeted questions are necessary. Sales of gabapentin have soared in recent years — not because it improves sexual satisfaction — but because it is seen as a safer pain reliever than opioid medication. Patients prescribed gabapentin often complain of side effects such as mood swings, depression, dizziness, fatigue and drowsiness. ED is listed as a potential side effect in the prescribing information for Gabapentin, along with other sexual dysfunction issues like decreased libido and ejaculatory and orgasmic dysfunctions. However, the likelihood of experiencing ED while taking Gabapentin can vary widely from person to person. Gabapentin helps me sleep, I take 800mg at night. It has seriously affected increased my libido and has become a problem. I am a 55 year old female who still has regular periods, and both ovaries, but I need to have a decreased libido and try something different for sleep. Sexual side effects from gabapentin aren’t common. But they’re possible and include decreased sex drive (libido) and trouble getting or keeping erections (erectile dysfunction). If you’re taking gabapentin and experiencing sexual problems, talk with your prescriber. Such sexual dysfunction may lead to medication noncompliance. Patients often do not volunteer information regarding sexual dysfunction, and therefore, targeted questions are necessary. Further education of health care professionals regarding gabapentin-induced sexual dysfunction is required. Sexual dysfunctions have been reported as a side effect of gabapentin doses as low as 300 mg daily. How Can You Treat Gabapentin-Induced Erectile Dysfunction? As a result of taking gabapentin, it’s possible for a few different sexual health issues to arise. Yes: Yes, gabapentin is known to very infrequently cause impotence or erectile dysfunction and abnormal ejaculation. A handful of case reports to the FDA over the past few decades also mention cases of sexual dysfunction with gabapentin in both men and women. The frequency of this adverse effect is unknown, although sexual side effects were reported as uncommon in clinical trials when epilepsy was treated. It is unknown if gabapentin might affect other areas of sexual functioning, although, in this man, it did not. I am also on 1800mg of Gabapentin daily for neuropathic pain and am unable to orgasm with my husband or on my own. We are very happily married and have a very healthy sex life, so I know it's the Gabapentin. I have previously been prescribed all the other usual medications for my nerve pain, but gabapentin has been the most effective so far. The link between gabapentin and erectile dysfunction may be due to gabapentin’s effects on neurotransmitters. Gabapentin is also associated with other sexual side effects, like difficulty reaching orgasm, although the science on this link isn’t totally clear. Although many people experience sexual dysfunction when using gabapentin, these side effects are not normally permanent. They are reversed when the medication stops. One study⁵ summarized 14 cases of orgasmic dysfunction in both men and women.
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