Olanzapine (Zyprexa) is an antipsychotic that can treat schizophrenia and bipolar disorder. It balances the levels of dopamine and serotonin in your brain. Locations : Common Trade Names: Zyprexa, Zydis; Adult Dosing. Acute agitation (associated with schizophrenia or bipolar disorder): Short-acting IM injection: initial dose: 10 mg IM (consider lowering to 5 or 7.5 mg depending on clinical factors), additional dose of 10 mg IM maybe considered. Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as olanzapine have an increased chance of death during treatment. Concomitant use of gabapentin and other CNS depressants has resulted in serious, life-threatening, or fatal respiratory depression. This Medication Guide summarizes the most important information about ZYPREXA.If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about ZYPREXA that was written for healthcare professionals. For more information about ZYPREXA call 1-800-Lilly-Rx (1-800-545-5979). When a medication works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another Description. Olanzapine is used to treat schizophrenia. It may also be used alone or with other medicines (eg, lithium or valproate) to treat mania or mixed episodes that is part of bipolar disorder (manic-depressive illness). Zyprexa is a prescription medicine used to treat the symptoms of schizophrenia and bipolar disorder (manic depression). Learn about side effects, dosage, drug interactions, warnings, and more. Zyprexa is available as 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, and 20 mg tablets. Tablets are not scored. Zyprexa Zydis. Active ingredient: olanzapine. Inactive ingredients: gelatin, mannitol, aspartame, sodium methyl paraben, and sodium propylparaben. Zyprexa Zydis orally disintegrating tablets are available as 5 mg, 10 mg, 15 mg, and 20 mg tablets. Reconstituted Zyprexa IntraMuscular may be stored at a controlled room temperature of 68°F to 77°F (20°C to 25°C) for up to 1 hour (allows for excursions of between 59°F to 86°F (15°C to 30°C)). Discard any unused product. Keep Zyprexa and Zyprexa Zydis away from light and moisture. Keep Zyprexa IntraMuscular away from light and do not Carbamazepine and gabapentin. As with valproate, the coadministration of carbamazepine with gabapentin appears safe, with no significant interactions ( 107 ). Hence, dose adjustments and additional blood level monitoring are not necessary. Applies to: gabapentin and Zyprexa (olanzapine) Using gabapentin together with OLANZapine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Carbamazepine decreases the plasma concentrations of both risperidone and its active metabolite. It also decreases concentrations of olanzapine, clozapine, ziprasidone, haloperidol, zuclopenthixol, flupenthixol and probably chlorpromazine and fluphenazine. This clinical study reports upon the efficacy of gabapentin (Neurontin) for treating severe akathisia (3 on the Barnes Akathisia Rating Scale) in two patients receiving quetiapine (Seroquel), one of whom also received olanzapine (Zyprexa) for a short period. For example, carbamazepine and primidone are potent inducers of cytochrome P450 enzymes and may effectively reduce serum levels and pharmacodynamic efficacy of drugs that undergo Phase I oxidative metabolism. Issue: Most patients with a bipolar spectrum disorder are treated with 2 or more drugs in combinations that are sometimes rational and evidence-based and sometimes not. a hot topic, with many new agents now available and many new combinations being touted. Adding gabapentin to olanzapine. Olanzapine is principally metabolized by CYP1A2 and CYP2D6. Gabapentin is eliminated unchanged by the kidney for 100%. This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. The cost of Zyprexa (olanzapine) can vary depending on various factors such as the dosage, formulation, and pharmacy. Generic versions of Zyprexa may be available, offering potential cost savings. The price of Zyprexa can range from around $62 for a supply of 1 intramuscular powder for injection٫ depending on the pharmacy and formulation. Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. [13] It is also sometimes used off-label for treatment of chemotherapy-induced nausea and vomiting [ 14 ] and as an appetite stimulant . [ 15 ] Customer: Hello - yesterday I was prescribed Gabapentin and Zyprexa (I have bipolar disorder), but when I checked interaction information, it said there's a moderate to severe interaction. Is this true, and should I not take them both together? Doctor's Assistant: The Pharmacist can help. Just a couple quick questions before I transfer you.
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