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Gabapentin can be used as an anticonvulsant. 5 You should also avoid certain herbal supplements while taking methadone such as St. John’s Wort and tryptophan as they can cause interactions as well. 4 Drug-drug interaction. This is when a medication reacts with one or more other drugs. Grapefruit or grapefruit juice. Too much of either can affect some drugs like: Statins; There are 3 main types of drug interactions to watch for: Drug-drug interactions: This is the most common type of drug interaction and involves one drug interacting with another. If you take many medicines, your chances for this type of interaction increases. From 2008 to 2012, the number of drugs known to potentially interact with grapefruit, with risk of harmful or even dangerous effects (gastrointestinal bleeding, nephrotoxicity), increased from 17 to 43. Grapefruit can interact with many medications, potentially affecting the way they work or increasing side effects. Some of these drugs include statins, blood pressure medications, buspirone, certain opioids, and more. Here are examples of some types of drugs that grapefruit juice can cause problems (interact) with: Some statin drugs to lower cholesterol, such as Zocor (simvastatin) and Lipitor (atorvastatin). No interaction: There are no known drug-food interactions between gabapentin and grapefruit. It is safe to eat/drink grapefruit while on gabapentin. Grapefruit can interact with other medications (e. g., birth control, blood pressure medications) so you may want to assess other medications or causes for possible interactions. Grapefruit and grapefruit juice can interact with many medications. Examples include some statins like simvastatin (Zocor), some calcium channel blockers like nicardipine (Procardia), and estrogen-containing medications like estradiol (Estrace). Mixing grapefruit with some medicines can cause serious health problems. If you take prescription medicines, ask a health care professional, such as a doctor or pharmacist, whether it's OK to eat grapefruit or other citrus products while taking the medicines. Grapefruit has many health benefits but can be dangerous if combined with certain medications. Here are 31 common medications that interact with grapefruit. Grapefruit juice is notorious for interacting with medications. This tangy beverage blocks the enzyme that metabolizes quetiapine, increasing blood levels of the medication. This raises the risk of side effects. If you’re a regular consumer of grapefruit or grapefruit juice, you may have to cut back while taking quetiapine. When you consume grapefruit or its juice while taking gabapentin, certain compounds found in grapefruit can interfere with the way your body processes the medication. This can lead to higher levels of gabapentin in your bloodstream, increasing the risk of side effects. Eating grapefruit is usually considered to be healthy, but the fruit can interact with drugs like Neurontin. Because grapefruit affects enzymes in the GI tract and liver that play a role in metabolizing medications, even if you take the correct dose, you could actually get an overdose of the drug. Evidence-based interaction details between Gabapentin (brand name(s): Neurontin, Gralise) and Grapefruit, including interaction severity and how likely the interaction is to occur. Common drug interactions include aphthous ulcer among females and abdominal pain among males. The phase IV clinical study analyzes what interactions people have when they take Grapefruit and Gabapentin, and groups them by gender, age and more. The study uses data from the FDA. It is based on grapefruit and gabapentin (the active ingredients of Grapefruit seed extract and Gabapentin, respectively), and Grapefruit seed extract and Gabapentin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. There are many common drug interactions with grapefruit juice. Medicines that can interact include certain cholesterol medicines, antihistamines, migraine treatments or even cancer therapies. If you eat grapefruit or drink the juice, review your medications with a healthcare provider to rule out this common drug-food interaction.
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