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Antacids with Al or Mg may cause a drug interaction that reduces the availability of gabapentin by about 20%, and may lower the effectiveness of the medicine. Common antacids that contain Al or Mg include: Amphojel, Gaviscon, Gelusil, Maalox and Mylanta. For instance, antacids can hinder gabapentin absorption and reduce its therapeutic benefits, while other medications may increase gabapentin levels to dangerous levels. Special Considerations It is vital to note that certain health conditions and life circumstances also impact the safe use of gabapentin: What are the more common side effects of gabapentin? Common side effects of gabapentin include: Feeling tired. Dizziness. Headache. Nausea and vomiting. Fever. Difficulty speaking. Recurring infections. Memory loss. Weight gain. Movement problems: coordination problems, being unsteady, tremors, jerky movements. A Minor Drug Interaction exists between gabapentin and Heartburn Antacid Extra Strength. View detailed information regarding this drug interaction. Antacids. Antacids (Maalox aluminum hydroxide/magnesium hydroxide) can reduce the oral bioavailability of gabapentin by 20%. To avoid problems, administration of gabapentin and antacids should be separated by at least 2 h . Cetirizine. Cetirizine can decrease mean plasma gabapentin levels, probably via interaction with renal drug transporters Administer gabapentin at least 2 hours after an antacid containing aluminum and magnesium. Rapid. Probable. Coadministration of gabapentin and an antacid containing aluminum hydroxide/magnesium hydroxide reduced the bioavailability of gabapentin by about 20%. Administer gabapentin at least 2 hours after an antacid containing aluminum and magnesium. Specific Medications: Gabapentin can also interact with specific medications including losartan (an antihypertensive), ethacrynic acid (a diuretic), phenytoin (an anticonvulsant), mefloquine (an antimalarial), magnesium oxide (an antacid), cimetidine (an antacid), naproxen (an NSAID), and sevelamer (a phosphate binder). These interactions can If you have any questions about the interaction between gabapentin and an antacid, talk to your doctor or pharmacist. Gabapentin and Benzodiazepines. Like gabapentin,benzodiazepinesare classified as CNS depressants and can intensify the drowsiness and dizziness side effects of gabapentin. While it is generally recommended that this combination However, this medicine can cause a number of side effects including heartburn and acid reflux. This blog will also cover some tips that can help you get rid of the acid reflux. Does gabapentin cause heartburn? Yes, gabapentin can cause heartburn and acid reflux. Gabapentin’s official labeling recommends waiting at least 2 hours after taking an antacid that contains magnesium or aluminum before taking a dose of gabapentin. This should help minimize the interaction between the two. Antacids can reduce the amount of gabapentin that the body takes in so it does not work as well. To stop this happening, if you need to take an antacid, take it at least 2 hours before or after your dose of gabapentin. Antacids, particularly those containing magnesium and aluminum, can interfere with the metabolism of the drug possibly leading to a reduction in its desired pharmacologic effects. In order to prevent this drug interaction, patients are advised to delay administration of gabapentin to at least 2 hours after taking the antacid. A dose of aluminum or magnesium hydroxide should precede a dose of gabapentin by at least two hours. Other antacids that contain aluminum or magnesium may interact with gabapentin in a similar fashion. The interaction between gabapentin and antacids, particularly magnesium oxide, significantly reduces gabapentin's bioavailability, which can compromise its therapeutic efficacy. In the context of perioperative pain management, gabapentin offers some benefits in reducing opioid consumption and postoperative pain, but these benefits are Antacids: Antacids, especially those containing magnesium or aluminum (e.g., magnesium oxide), can interfere with gabapentin’s absorption. This can reduce its effectiveness, potentially leading to breakthrough symptoms. Understand Drug Interactions: Gabapentin interacts with opioids, antacids, and more. Opioid Risks: Combining gabapentin with opioids can lead to increased sedation. Antacid Timing Matters: Take antacids at least two hours apart from gabapentin. Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin. Some of the main substances that interact with gabapentin are morphine, caffeine, losartan, ethacrynic acid, phenytoin, mefloquine and magnesium oxide. Some of the side effects caused by gabapentin are teratogenicity, hypoventilation, respiratory failure and myopathy.
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