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My kitty is going for bloodwork tomorrow because the vet is pretty sure she has pancreatitis. She never does well with bloodwork and the past two times they had to put her under for it. This time they gave me gabapentin to give her an hour or two before her appointment. Gabapentin is not metabolized or protein bound, and is cleared only by renal excretion in humans; it is unknown whether this is also true in cats. 7 In humans, it has been demonstrated that kidney disease significantly influences the pharmacokinetics (PK) of gabapentin, and a 60% and 85% decrease in gabapentin clearance is seen in moderate and Reduced Blood Pressure and Heart Rate: Several studies have shown that gabapentin can reduce both blood pressure and heart rate in cats. Specifically, one study noted an average 12 bpm decrease in heart rate in gabapentin-treated cats compared to those given a placebo. Situational increases in blood pressure (BP) frequently confound the accurate diagnosis of pathological systemic hypertension in cats. The objective of this study was to investigate the effect of gabapentin on direct, ambulatory systolic arterial BP (SBP) in cats in at-home and in-clinic environments. Gabapentin is eliminated almost entirely through renal excretion, and decreased renal function significantly influences the pharmacokinetics of gabapentin in humans. 14 While doses of gabapentin in the range of 50–150 mg/cat have been used in normal cats, 4,5,11 it should be noted that higher doses may be unsuitable for cats with CKD. 15 In a Gabapentin doesn’t typically directly raise blood pressure but instead may reduce it. Situational increases in blood pressure are possible in some cats. Research suggests it can lower both blood pressure and heart rate through its action in the brain. Gabapentin is an anticonvulsant drug effective in humans to control neuropathic pain. In veterinary medicine, is extra-label used in combination with other treatments to control seizures when other drugs are not effective, when drugs are toxic, or for neuropathic pain treatment and anxiety. The authors concluded that gabapentin affects BP in cats with and without CKD, which should be considered when gabapentin is administered to cats that require BP measurement. Gabapentin may decrease arterial BP in cats with and without CKD and these findings should be taken into account when gabapentin is administered to patients in which measurement of BP is needed. Objectives The aim of the present study was to assess the effect of gabapentin on blood pressure (BP) in cats with and without chronic kidney disease (CKD). Methods A randomized, blinded, placebo Objectives: The aim of the present study was to assess the effect of gabapentin on blood pressure (BP) in cats with and without chronic kidney disease (CKD). Methods: A randomized, blinded, placebo-controlled crossover study was performed. A total of 29 cats were included: 13 cats with stable CKD (IRIS stage 2-4) and 16 apparently healthy cats Gabapentin is eliminated almost entirely through renal excretion, and decreased renal function significantly influences the pharmacokinetics of gabapentin in humans. 14 While doses of gabapentin in the range of 50–150 mg/cat have been used in normal cats, 4,5,11 it should be noted that higher doses may be unsuitable for cats with CKD. 15 In a Gabapentin may decrease arterial BP in cats with and without CKD and these findings should be taken into account when gabapentin is administered to patients in which measurement of BP is needed. Visits to the veterinary clinic can be a source of stress for both the feline patient and the caregiver. Increasing doses of alfaxalone in cats will produce a dose-dependent decrease in cardiac output and arterial blood pressure; however, at clinical doses, heart rate is preserved and decreases in systemic vascular resistance are minimal. 33,34 Alfaxalone presents an advantage over other injectable anesthetics in its ability to be injected Conclusions and relevance: Significant effects of gabapentin on direct SBP were not identified, though a type II error is possible. Situational increases cannot be excluded in gabapentin-treated cats with high SBP. Keywords: Blood pressure; Doppler sphygmomanometry; radiotelemetric catheter; simulated veterinary visit. The aim of this study was to evaluate, using echocardiography, the effects of oral administration of a single dose of gabapentin on the physiologic variables (heart rate [HR], respiratory rate [RR] and systolic blood pressure [SBP]) and systolic and diastolic cardiac function of healthy cats. The cats were evaluated twice, approximately 1 week apart, and BP (Doppler sphygmomanometry) was obtained 3h after cats received either a single dose of gabapentin 10 mg/kg PO or placebo. Gabapentin is eliminated almost entirely through renal excretion, and decreased renal function significantly influences the pharmacokinetics of gabapentin in humans. 14 While doses of gabapentin in the range of 50–150 mg/cat have been used in normal cats, 4,5,11 it should be noted that higher doses may be unsuitable for cats with CKD. 15 In a Gabapentin is eliminated almost entirely through renal excretion, and decreased renal function significantly influences the pharmacokinetics of gabapentin in humans. 14 While doses of gabapentin in the range of 50–150 mg/cat have been used in normal cats, 4,5,11 it should be noted that higher doses may be unsuitable for cats with CKD. 15 In a Gabapentin is eliminated almost entirely through renal excretion, and decreased renal function significantly influences the pharmacokinetics of gabapentin in humans. 14 While doses of gabapentin in the range of 50–150 mg/cat have been used in normal cats, 4,5,11 it should be noted that higher doses may be unsuitable for cats with CKD. 15 In a If our study finds that gabapentin affects the function of normal cats significantly, judicious use of this medication will be recommended for cats with known or suspected cardiac disease. Benefits. Cats in this study will receive a physical examination, two blood pressure checks, two echocardiograms and two electrocardiograms (ECG).
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