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Purpose: A case of probable gabapentin-induced visual hallucinations in a patient with no psychiatric history is reported. Summary: A 65-year-old white woman with no history of psychiatric Gabapentin can cause some rare but serious side effects. While these are uncommon, people should be aware of them and seek medical attention if needed. Gabapentin is also used to manage a condition called postherpetic neuralgia, which is pain that occurs after shingles. Gabapentin works in the brain to prevent seizures and relieve pain for certain conditions in the nervous system. It is not used for routine pain caused by minor injuries or arthritis. Gabapentin is an anticonvulsant. According to glutamatergic theories of schizophrenia, glutamate dysfunction, for example a significant reduction of glutamate levels caused by pregabalin could be the cause of hallucinations and other psychotic symptoms . More data is needed to understand the pathophysiology of pregabalin induced hallucinations and psychotic symptoms. Gabapentin, one of the antiepileptics, shows its effects via voltage-gated calcium channels. Sedation and mood elevation are among its side effects. High doses of gabapentin can cause autolytic ideation and auditory hallucinations, but stopping treatment resolves symptoms without recurrence. Gabapentin effectively improved both visual hallucinations and pain in a Parkinson's disease patient without adverse effects. In this article, we report four cases of hallucinations associated with sensory impairment, three visual hallucinations and one musical hallucination, that responded to gabapentin. To our knowledge, this is the only case of musical hallucinations successfully treated with gabapentin. Gabapentin was started in a dose of 300 mg bid, and sodium valproate was stopped. Within 48 hours, the patient developed new symptoms of hostility, verbal aggression, and command auditory hallucinations and destroyed property by breaking the commode in his room. The patient clearly attributed these new symptoms to gabapentin. Gabapentin is already on the list of drugs that can cause auditory hallucinations. In fact, hundreds and hundreds of people have reported hearing phantom sounds as a result of taking this drug. It also causes hearing loss in even more people. It’s never a good idea to go off a drug “cold turkey” when you’ve been on it for a while. Some side effects of gabapentin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Hallucinations is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Nuplazid, and have Parkinson's disease. I’m so happy someone else is having the same issues . I started on gabapentin last Friday 100mg before bed. First night I had a migraine so bad I couldn’t even sleep and since then I’m having such vivid nightmares I can’t tell when I’m awake or sleeping. She had decreased hearing bilaterally despite hearing aids. Gabapentin, 100 mg h.s., was started, and the musical hallucinations resolved in 3 days. One month later, gabapentin was discontinued at the patient’s request, and the same music started within 2 days. Restarting the gabapentin regimen ended the hallucinations in 4 days. More rarely, gabapentin can cause fluid buildup (edema), weight gain, and vision problems. It can also cause diarrhea. More serious (but rare) side effects include suicidal thoughts or behavior, and mood changes in children. Our subgraph shows that Olanzapine and Gabapentin are genetically similar drugs that are potentially associated with hallucination. There have been some case reports of hallucination while Background Pregabalin is an anticonvulsive, analgesic and anxiolytic medication. The typical side effects include dizziness, somnolence and weight gain. Few studies or case reports have demonstrated psychiatric side effects resulting from its use. Case presentation We present a patient who suffered visual hallucinations and agitation associated with an increase in pregabalin dose, resolving tance, crying, out loud self-talk, visual hallucinations, decreased sleep, and loss. Gabapentin and pregabalin are structurally related compounds with recognized efficacy in the treatment of A 65-year-old woman with no psychiatric history developed visual hallucinations while taking gabapentin five times daily. Her hallucinations resolved after discontinuation of gabapentin and have remained absent after 1 year of follow-up. Much of the research into whether or not gabapentin can cause hallucinations is inconclusive. However, it can be said that some people have reported experiencing hallucinations while taking the medication, so it is important to be aware of the potential risks associated with taking gabapentin. Borobia-Perez reported about an 82-year-old woman already on gabapentin 300 mg/8 h for chronic pain. She developed psychosis, visual hallucinations, and worsened renal function after increasing the dosage of the drug to 600 mg/8 h and addition of 10 mg/day morphine. Patient’s symptoms ceased after stopping of gabapentin and morphine. 5
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