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A Minor Drug Interaction exists between cimetidine and gabapentin. View detailed information regarding this drug interaction. Magnesium Oxide, Cimetidine, Naproxen and Sevelamer: These drugs affect the absorption of gabapentin in the gastrointestinal tract. Magnesium oxide can reduce the absorption of gabapentin, potentially making it less effective. 482 medications are known to interact with cimetidine. Includes gabapentin, acetaminophen, atorvastatin. Cimetidine (histamine H2 receptor antagonist): Cimetidine may increase the concentration of gabapentin in the blood. Naproxen (nonsteroidal anti-inflammatory drug – NSAID): NSAIDs, including naproxen, may increase the risk of certain side effects when taken with gabapentin. Specific Medications: Gabapentin can also interact with specific medications including losartan (an antihypertensive), ethacrynic acid (a diuretic), phenytoin (an anticonvulsant), mefloquine (an antimalarial), magnesium oxide (an antacid), cimetidine (an antacid), naproxen (an NSAID), and sevelamer (a phosphate binder). These interactions can 1. Bungard TJ, et al. Drug interactions involving warfarin: practice tool and practical management tips. CPJ/RPC. 2011 Jan/Feb. 144(1). 2. Interactions with Coumadin [package insert]. Princeton, NJ: Bristol‐Myers Squibb; 2013. Drug Interactions with Warfarin Med Cart Reference Guide Risk of Increased INR (Overcoagulation) Concurrent use of cimetidine and gabapentin may decrease the renal excretion of the drug, potentially leading to an in increase gabapentin levels in the blood. However, studies suggest that the small decrease in gabapentin clearance is not expected to cause serious adverse reaction. In addition, the interaction between gabapentin and antacid substances such as magnesium oxide Citation 89 and cimetidine has been demonstrated; Citation 90 specifically, cimetidine reduced 12% of gabapentin’s clearance by decreasing its glomerular filtration rate Citation 90 (as a reference, cimetidine is an antagonist of the histamine H2 GABAGoodness is devoted to the discussion of all GABAergics, Gabapentnoids and VDCC inhibitors such as Pregabalin, Gabapentin, Phenibut, Carisoprodol, GHB, Benzodiazepines, Barbiturates, and more! This is a great place to ask general or recreational questions, get harm reduction advice, or share your experience with withdrawal syndromes. Gabapentin can interact with losartan, ethacrynic acid, caffeine, phenytoin, mefloquine, magnesium oxide, cimetidine, naproxen, sevelamer and morphine. Gabapentin use is contraindicated in patients with myasthenia gravis or myoclonus. The effect of antacids, cetirizine, cimetidine, hydrocodone, morphine, naproxen, probenecid and Shiitake mushroom on the pharmacokinetics of gabapentin are described. To date, no pharmacodynamic interactions, involving gabapentin, have been reported. Use WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Drug Interactions between gabapentin and Tagamet. This report displays the potential drug interactions for the following 2 drugs: gabapentin; Tagamet (cimetidine) Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs Drug interactions are reported among people who take Gabapentin (gabapentin) and Tagamet (cimetidine). Common drug interactions include fall among females and chronic kidney disease among males. The phase IV clinical study analyzes what interactions people have when they take Gabapentin and Tagamet, and groups them by gender, age and more. This interaction suggests that dose adjustments of gabapentin may be necessary when co-administered with cimetidine to avoid potential toxicity. Antiepileptic Drugs and Gabapentin Gabapentin's interaction with other antiepileptic drugs like phenytoin has been documented. To examine the potential for drug–drug interactions at these two transporters, the pharmacokinetics of gabapentin enacarbil were evaluated in healthy adults after administration alone or in combination with either naproxen (an MCT-1 substrate) or cimetidine (an OCT2 substrate). Use the interactions A to Z to look up a drug and see which other drugs it interacts with and the severity of these interactions. Similarly, there was no effect on cimetidine exposure when gabapentin enacarbil and cimetidine were dosed concomitantly. Again, these results were consistent with published data for concomitant treatment with gabapentin and cimetidine . When cimetidine 300 mg was dosed four times daily, the mean apparent oral clearance of gabapentin was reduced Drug Interactions between gabapentin and Tagamet HB. This report displays the potential drug interactions for the following 2 drugs: gabapentin; Tagamet HB (cimetidine) Edit list (add/remove drugs) Consumer; Professional; Interactions between your drugs Fluoxetine Interactions. There are 680 drugs known to interact with fluoxetine, along with 12 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 165 are major, 493 are moderate, and 22 are minor.
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