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Clomipramine (Anafranil) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. Clomipramine oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent Drugs that can play a role in serotonin syndrome in pets include Anipryl (selegiline or L-deprenyl), Mitaban and Preventic (amitraz), Clomicalm (clomipramine), Reconcile and Prozac (fluoxetine), and amitriptyline. Gabapentin has the following interaction information: Severe interactions are highlighted with a red marker. Both Gabapentin and Agomelatine have effects on the CNS and can cause sedation, which might affect the ability to perform skilled tasks (see 'Drugs and Driving' in Guidance on Prescribing). The risk or severity of adverse effects can be increased when Clomipramine is combined with Gabapentin Enacarbil. Gadobenate Clomipramine may increase the QTc-prolonging activities of Gadobenic Clomipramine is a tricyclic antidepressant (TCA) that primarily exerts therapeutic effects through potent serotonin reuptake inhibition. This medication is FDA-approved to treat obsessive-compulsive disorder (OCD) in patients aged 10 and older. Clomipramine's off-label uses include depression, anxiety, insomnia, and chronic pain. This educational activity reviews the indications, mechanism of Clomipramine is used to treat obsessive compulsive disorder (OCD). OCD is a nervous condition wherein a person has recurring thoughts or ideas or does repetitive things because they are anxious. Clomipramine is a tricyclic antidepressant (TCA). It is thought to work in the brain by increasing the activity of the chemical serotonin. ~ 17 L/kg (range: 9-25 L/kg). Clomipramine is capable of distributing into the cerebrospinal fluid, the brain, and into breast milk. Protein binding. Clomipramine is approximately 97-98% bound to plasma proteins, principally to albumin and possibly to α 1-acid glycoprotein. Desmethylclomipramine is 97-99% bound to plasma proteins. 791 medications are known to interact with clomipramine. Includes amlodipine, gabapentin, lisinopril. When you're done, check for possible drug interactions. Never use this combination of drugs because of high risk for dangerous interaction. Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed. Potential for significant interaction (monitoring by your doctor is likely required) Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). [7] It is used in the treatment of various conditions, most notably obsessive–compulsive disorder but also many other disorders, including hyperacusis, panic disorder, major depressive disorder, trichotillomania, [8] body dysmorphic disorder [9] [10] [11] and chronic pain. [7] Compare Clomipramine vs Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Clomipramine can make you feel sleepy so your doctor may advise you to take a small dose when you first start taking it, and then to increase your dose gradually as your body gets used to it. It is usual to take clomipramine once a day at bedtime, although it can also be taken in smaller doses two or three times a day. Drug Interactions. Clomipramine should not be taken while you are using certain other medicines. Using clomiPRAMINE together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Medscape - Indication-specific dosing for Anafranil (clomipramine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. There is some evidence for the latter (Baker 2003), but most results suggest a flat dose–response relationship for SSRIs when used as monotherapy (Adli 2005). Nausea and tremor are common with the citalopram–fluvoxamine combination but no serious side-effects were noted from either reported series. What is clomipramine? Clomipramine is a tricyclic antidepressant that is used to treat symptoms of obsessive-compulsive disorder (OCD), such as recurrent thoughts or feelings and repetitive actions. Clomipramine is for use in adults and children at least 10 years old. Clomipramine may also be used for purposes not listed in this medication guide. the following nonprescription product may interact with clomipramine: cimetidine (Tagamet). Be sure to let your doctor and pharmacist know that you are taking this medication before you start taking clomipramine. Do not start this medication while taking clomipramine without discussing with your healthcare provider. Use WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question.
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