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Despite its popularity, there is a narrow indication of its use in veterinary patients. There is also growing evidence that gabapentin is being diverted for recreational drug use, sometimes with fatal consequences. Gabapentin should be USED WITH CAUTION in pets that: Do not stop this medication abruptly in pets with epilepsy, as this can cause withdrawal seizures. Some liquid oral formulations contain xylitol, a sugar substitute that is toxic to dogs, so be cautious and read the label before administering. Gabapentin is a human medication, and its use in veterinary medicine is “off-label,” meaning it is not FDA-approved for pets. Sedation is the main potential side effect of gabapentin, and the level of sleepiness varies from patient to patient. NEURONTIN safely and effectively. See full prescribing information for NEURONTIN. NEURONTIN ® (gabapentin) capsules, for oral use NEURONTIN ® (gabapentin) tablets, for oral use NEURONTIN ® (gabapentin) oral solution Initial U.S. Approval: 1993 ----- Warnings and Pr ecautions, Respiratory Depression (5.7) 04/2020 Targeted Use of Gabapentin. One of the most commonly cited uses of gabapentin in veterinary medicine is for treating acute post-operative pain. 5 Considering the mechanism of action of gabapentin and its impact on pain signaling, it is unlikely that gabapentin will be an effective analgesic in this context. Inflammation is the most common Classic veterinary medical education places a strong emphasis on treatment of disease through pharmacology and surgery, the 68 JAAHA | 51:2 Mar/Apr 2015. Medications are given for a number of different reasons, and they may not be appropriate for specific individuals. Medication and supplements should only be given to your pet under the direct instruction of your veterinarian. Gabapentin is not safe for use in pregnancy but should be safe for use in lactation. Gabapentin should not be abruptly discontinued after long-term use as seizures can be precipitated. Instead, gabapentin should be gradually tapered off over a couple of weeks. J Vet Med Res 7(4): 1194. Cetral Journal of Veterinary Medicine and Research *Corresponding author Lori R Kogan, College of Veterinary Medicine and Bio-medical Sciences, Colorado State University, Fort Collins, CO 80523, United States, Tel: 970 491-7984; Email: lori. kogan@colostate.edu Submitted: 14 July 2020 Accepted: 10 August 2020 Published Veterinary use of gabapentin has increased dramatically over the past several years, probably as an oral analgesic alternative to non-steroidal anti-inflammatory drugs (NSAIDs) and as a result of the lack of evidence for the analgesic effects of tramadol in some species, particularly dogs (Davila et al. 2013; KuKanich 2013; Donati et al. 2021). It’s important to understand a medication’s uses and side effects before giving it to your pet. This medication info sheet is meant to give you a good understanding of what gabapentin is used for, how it works, and potential side effects in cats and dogs. Always consult a veterinarian before giving your pet any medication. 1. Drug Name: 2. Gabapentin prescribing trends in the UK - Paper. 97% of US gabapentin prescriptions were off label between 2003 and 2016 - Abstract. Prescribing practices for gabapentin as a painkiller among veterinary professionals - Abstract. Gabapentin’s effectiveness as a surgical pain reliever evaporates when compared to a sedative - Abstract In veterinary medicine, is extra-label used in combination with other treatments to control seizures when other drugs are not effective, when drugs are toxic, or for neuropathic pain treatment and anxiety. This review aimed to clarify gabapentin use and pharmacokinetic aspects to promote conscious use in dogs, cats, and horses. Pharmacodynamics. Gabapentin is an anti-convulsant medication that inhibits the release of excitatory neurotransmitters, allowing for its use against pathologic neurotransmission such as that seen in neuropathic pain and seizure disorders. 16,19 It has a wide therapeutic index, with doses in excess of 8000 mg/kg failing to cause a fatal reaction in rats. 21 Vet Clin North Am Small Anim Pract 2008;38(6):1365-1414. Moore SA. Managing neuropathic pain in dogs. Front Vet Sci 2016;3(12):1-8. KuKanich B. Outpatient oral analgesics in dogs and cats beyond nonsteroidal antiinflammatory drugs: an evidence-based approach. Vet Clin North Am Small Anim Pract 2013;43(5):1109-1125. Gabapentin The medicine you have been given for your dog or cat is called gabapentin. It may have a trade name such as Neurontin®, but often will just be called gabapentin. What is gabapentin? Gabapentin belongs to a group of medicines that are called anti-epileptics. These drugs act on the brain to prevent epileptic seizures (fits). Some anti- In veterinary medicine, gabapentin is utilized for both acute and chronic pain. However, its use in this manner is not backed by strong scientific evidence. There are no FDA labeled indications for gabapentin use in animals, but it is noted as having extra-label use in dogs for ancillary therapy of refractory seizures and as an adjunctive Are there any contraindications for Gabapentin use in dogs? Gabapentin should not be used in dogs with a known allergy to the medication or in pregnant or nursing animals, unless deemed necessary by a veterinarian. Drowsiness and clumsiness (ataxia) are the primary side effects of gabapentin. The level of sleepiness varies, so veterinarians generally prescribe a starting dose and then adjust the dosage up or down. Diarrhea and vomiting are less common, but still possible. Veterinary studies of the use of this drug are limited. Sudden withdrawal should be avoided. Dose should be decreased gradually over 1 week if discontinuing use when treating seizures.
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