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To explore the association between gabapentin use and the risk of dementia in patients with chronic pain, considering the rising concerns of dementia in an aging population and the potential cognitive impacts of chronic pain management. Applying the inclusion and exclusion criteria yielded 201,492 patients for the study: 25,373 in the dementia cohort and 174,930 in the non-dementia cohort. Post 1:1 matching, and after excluding recent gabapentin use (within three months of the index date), the study comprised 22,769 individuals in the dementia cohort and 22,644 in the non-dementia Complementing this formal systematic review, an illustrative case of a patient with BPSD in mixed Alzheimer's/vascular dementia, who appeared to derive benefits in terms of symptom control and functioning from the introduction of gabapentin titrated up to 3600 mg day-1 alongside other interventions, is presented. Two common classes of drugs have been linked to dementia. Fortunately, there are alternatives to both. If you're worried about developing dementia, you've probably memorized the list of things you should do to minimize your risk—eating a healthy diet, exercising regularly, getting adequate sleep, and keeping your mind and soul engaged. While dementia and chemo brain both result in memory loss, they are different in many ways. Dementia leads to gradual cognitive changes and is incurable. Chemo brain, on the other hand, is directly linked to cancer or its treatment and often improves over time. That doesn't mean these drugs caused dementia. There are other potential explanations for the findings. For example, some people develop depression during the early phases of dementia. Rather than antidepressants causing dementia, the medication might be prescribed for early symptoms of dementia that has already developed. Over 1 or 2 years of follow-up, gabapentin initiation was not associated with decline in cognitive or functional status but was associated with increased odds of falling among research participants with cognitive impairment. Dementia is a broad term for conditions that can impair someone’s ability to remember, process information, and speak. Early indicators can include issues with short-term memory and word finding. Dementia is an umbrella term that describes impaired memory loss and changes to cognition in various medical conditions. While it’s commonly associated with older people, dementia isn’t a part We would like to show you a description here but the site won’t allow us. Gabapentin initiation was significantly associated with cognitive/functional status decline: worsening CDRGLOB at index+1 visit (odds ratio [95% confidence interval]: 1.55 [1.07, 2.25]); CDR-SB at index+1 visit (1.94 [1.22, 3.09]); and mean of FAQ at index+2 visit (1.78 [1.12, 2.83]). Gabapentin use was significantly associated with decline in cognitive and functional status among older adults with initially normal cognition. Further studies are needed to examine the association. The HR (95% CI) of dementia for gabapentin or pregabalin exposure was 1.45 (1.36–1.55) compared to non-exposure group, after adjustment for diabetes mellitus, hypertension, stroke, hyperlipidemia, depression, and head injury. Especially in older adults, gabapentin is prescribed to treat behavioral and psychological symptoms of dementia (BPSD) (Kim et al., 2008). Several studies have reported that gabapentin has a deleterious effect on cognition (Leach et al., 1997; Meador et al., 1999; Shem et al., 2018). In a seminal trial on pain following shingles (post-herpetic neuralgia), the target dose of gabapentin was 900 mg four times daily. It often takes weeks or months to build up to this dose so that Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. However, the relation between gabapentin initiation and longer-term neurocognitive changes is not well understood. And since treatment options for dementia are limited, prevention is key. Dementia risk is tied to common things like diabetes, high blood pressure, and physical inactivity. But some common medications are associated with dementia risk, too. Here are four common drug classes linked to dementia, and what the research says about your risk. 1. There’s mounting evidence supporting a connection between certain medications (anticholinergics and benzodiazepines) and dementia. An expert discusses the latest research and what to do if you We present the case of a patient with incipient vascular dementia accompanied by nocturnal agitation, which was successfully treated with gabapentin. Gabapentin appears to be useful and well-tolerated in this indication. Gabapentin and pregabalin to treat aggressivity in dementia: a systematic review and illustrative case report Article date: April 2019 By: Thitiporn Supasitthumrong, Blanca M. Bolea‐Alamanac, Selim Asmer, Vincent L. Woo, Petal S. Abdool, Simon J.C. Davies in Volume 85 , Issue 4 , pages 690-703
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