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Gabapentin has been shown to be safe and effective for mild alcohol withdrawal but is not appropriate as mono-therapy for severe withdrawal owing to risk of seizures. During early abstinence, gabapentin may improve sleep, cravings, and mood—factors associated with relapse. Recently, numerous studies have evaluated the use of drugs for abstinence in patients with alcohol use disorders, such as pregabalin (Martinotti et al., 2010), gabapentin (Mattle et al., 2022), and acamprosate (Tyson and Lewis, 2022). Although gabapentin appears to be more efficacious than placebo in treating AUD, the only measure on which the analysis clearly favors the active medication is percentage of heavy drinking days. Additional studies are needed to define more clearly the role of gabapentin in AUD treatment. use disorders.32,40,41 To date, no review has focused exclu-sively on the use of gabapentin for the treatment of tobacco use disorder. Gabapentin Use in Treating Alcohol-Related Problems The majority of studies that have explored the use of gabapentin for treating alcohol use disorders have included Gabapentin has an average rating of 9.0 out of 10 from a total of 66 reviews for the off-label treatment of Alcohol Withdrawal. 89% of reviewers reported a positive experience, while 2% reported a negative experience. GABAPENTIN AND ALCOHOL USE DISORDER No effect was found of gabapentin use for benzodiazepine treatment of alcohol withdrawal. It is notable that Bonnet et al and Nichols et al had similar fi ndings despite their studies being conducted in different countries using distinct comparators and methods. Bonnet et al,27 in another study, tried Studies of the efficacy of gabapentin for treating alcohol use disorder (AUD) have yielded mixed findings. The aims of our study were to estimate gabapentin’s effects on six alcohol-related outcomes, test potential moderators, examine publication bias, and evaluate the quality of the studies. Ketamine – There has been a resurgence of interest in the role of ketamine, a decades-old dissociative anesthetic, in the treatment of several substance use disorders, including alcohol use disorder. In a review including seven studies using ketamine for the treatment of alcohol use disorder, ketamine, typically administered by intravenous Previous reviews have described the use of gabapentin for treating alcohol use disorder, Citation 30 – Citation 39 but, few have described the use of gabapentin for treating tobacco use disorders. Citation 32 , Citation 40 , Citation 41 To date, no review has focused exclusively on the use of gabapentin for the treatment of tobacco use disorder. Gabapentin is a medication that has been used for seizures since the 1990s. It’s now being reconsidered and researched as a treatment for alcohol use disorder. Gabapentin has been shown to be safe and effective for mild alcohol withdrawal but is not appropriate as mono-therapy for severe withdrawal owing to risk of seizures. During early abstinence, gabapentin may improve sleep, cravings, and mood—factors associated with relapse. Gabapentin has the potential for abuse, especially in those with a history of other substance use disorders, including alcohol, opioid, and cocaine use disorders. 52 One systematic review of 106 studies concluded that while there is not “convincing evidence of a vigorous addictive power of gabapentinoidsin patients without a prior abuse However, gabapentin enacarbil (Horizant), a proprietary prodrug of gabapentin that produces extended release of gabapentin and is FDA-approved for pain and restless leg syndrome, is currently being evaluated as a treatment for alcohol use disorder in a Phase II multi-center trial (1200mg/d) conducted by the National Institute on Alcohol Abuse APA’s 2018 practice guideline on AUD pharmacotherapy suggests psychiatrists consider gabapentin for patients with moderate to severe alcohol use disorder who prefer gabapentin or are intolerant to or have not responded to the FDA-approved medications naltrexone and acamprosate. Gabapentin can be a second-line, off-label option to treat AUD. However, there is mixed evidence and concerns about abuse-misuse, and drug-related harms. Results are statistically significant unless indicated. Some research shows that gabapentin has promise as an alcohol withdrawal treatment, possibly in combination with other medications. Gabapentin can: A clinical trial showed that people with Gabapentin is efficacious for the treatment of acute alcohol withdrawal symptoms 29, 30 and also provides short-term relapse prevention after medicated alcohol detoxification, 31 perhaps by an effect on sleep normalization. 32, 33 Post hoc analysis has shown effectiveness of treatment with gabapentin, in combination with flumazenil 34 or naltrex Gabapentin is effective at reducing drinking among people with alcohol use disorder (AUD) and strong withdrawal symptoms, according to a study published in JAMA Internal Medicine. Evidence from single-site studies lend support to the safety and efficacy of gabapentin as a novel treatment for alcohol use disorder, with unique benefits for alcohol-related insomnia and negative affect, relative to available treatments. Gabapentin is an off-label medication for alcohol use disorder, sold under the brand names Neurontin, Gralise, and Horizant, among others. The medication was originally developed to treat epilepsy and is now FDA-indicated for a variety of additional uses, including the treatment of conditions like postherpetic neuralgia and restless leg syndrome.
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