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In this article, we provide a review of current psychopharmacological treatment in ASD including those used to address common comorbidities of the condition and upcoming new targeted approaches in autism management. Antipsychotics can be very effective for irritability in autism, but they are often unnecessary, and the side effects are truly problematic. Don’t be the prescriber who hears irritability in autism and immediate prescribes antipsychotics. There are usually multiple steps to try before using the FDA approved antipsychotic medications. People with autism and Asperger’s syndrome are particularly vulnerable to mental health problems such as anxiety and depression, with prevalence rates estimated at around 35%. Even higher rates Post mortem brain studies from individuals with autism have documented abnormalities in the cholinergic system and a connection between Alzheimer’s disease and autism has been proposed by many researchers [53,54]. One of the Alzheimer medications, donepezil, was found to be effective in improving behavioral and attention issues in autism. (Tegretol), lamotragine (Lamictal), oxycarbazine (Trileptal ), topiramate (Topomax), gabapentin (Neurontin), and ethosuccimide (Zarontin). AEDs are also often useful to help persons with ASDs attain better mood stability, however there are many different kinds of AEDs, with different side effects, and I take gabapentin for anxiety/panic attacks (nighttime). This is the second time I’ve been prescribed it in my life. The first time was 3x daily, but I built up a tolerance rather quickly. Getting off of it was really difficult, so I definitely suggest tapering down with a doctor’s supervision if this medication doesn’t work out for your You may be onto something with your observation. Gabapentin seems to help people that have the herpes zoster virus (chickenpox virus). There is research showing people that have antibodies to that virus have higher rates of autism. I have autism as well and find gabapentin to be helpful and family members that also have autism have reported the prescribed anti-anxiety medications (i.e. SSRI), none has been proved extremely effective to treat anxiety in ASD. Gabapentin is an aminoacid derivative of gamma-amino butyric acid (GABA). It was originally developed as an antiepileptic drug, but to date is frequently used to treat anxiety [3] as well as primary insomnia [4]. [Show full abstract] autism such as association of g-band frequency with the cortical concentration of GABA and gabapentin (GABA analogue) specifically inhibits the cytosolic branched chain amino Benzodiazepines target certain receptors for the neurotransmitter GABA (gamma-aminobutyric acid), an inhibitory chemical that dampens specific brain-wave activity and is one of the most common We would like to show you a description here but the site won’t allow us. While behavioral interventions remain the mainstay of treatment of autism spectrum disorder (ASD), several potential targeted treatments addressing the underlying neurophysiology of ASD have emerged in the last few years. These are promising for the potential to, in future, become part of the mainstay treatment in addressing the core symptoms of ASD. Although it is likely that the development Gabapentin’s anxiolytic properties, which have been well-documented in other contexts, could provide significant relief for those struggling with anxiety symptoms. Improved sleep patterns and quality are another potential benefit of gabapentin use in autism. We would like to show you a description here but the site won’t allow us. Gabapentin in divided doses 3 times a day, totaling 900 to 1800 mg a day were effective as add-on to valproic acid and low dose antipsychotic, and also in a subset replaced lithium and thus eliminated lithium side effects. Gabapentin is very benign and can be helpful for anxiety and for sensory hypersensitivity. Topiramate can reduce perseverative thinking and typically reduces appetite, but may interfere with word finding, which can be problematic for this population.
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