Gabapentin is a medication that may be used off-label to treat anxiety symptoms, though it is most often prescribed for nerve pain and some seizure disorders. Pharmacotherapy for anxiety disorders in children will be discussed here. The epidemiology, pathogenesis, clinical manifestations, course, and diagnosis of anxiety disorders in children are discussed separately. They generally work better for anxiety than depression for neurotypical kids and teens, but research on SSRIs in autistic children is limited. A recent controlled trial of sertraline for language outcomes in young autistic children ages 24–72 months showed no effect but no significant side effects either (Potter LA et al, Front Psychiatry For anxiety treatment, gabapentin is typically prescribed at doses ranging from 300 mg to 900 mg per day, depending on individual patient response and tolerance. Pregabalin, given its higher potency, is usually administered at doses between 150 mg and 600 mg per day, divided into two or three doses. Gabapentin can be prescribed to children for specific medical conditions, but its use in pediatric patients depends on the age of the child, the condition being treated, and the guidance of a healthcare provider. Here’s an overview: Approved Uses of Gabapentin for Children. Epilepsy (Seizure Disorders): While gabapentin is increasingly being used to treat generalized anxiety disorder (GAD), little is known about its effectiveness on GAD symptoms. The patient presented here has a relatively straightforward psychiatric history, with GAD playing a prominent role. For example, buproprion, an inhibitor of dopamine and norepinephrine, has not been studied in children or adolescents with anxiety. Similarly, gabapentin has limited evidence of improvement in anxiety symptoms in adults, 71, 72 but has not been tested in youth. The safety and efficacy of gabapentin in children undergoing surgery has been evaluated in several clinical trials. In 2010, Rusy and colleagues conducted a randomized double-blind placebo-controlled trial of gabapentin in 59 children 9 to 18 years of age undergoing spinal fusion.7 Patients were randomized to receive gabapentin G Gabapentin—Neurontin, Gralise, Gralise Starter Page 3 of 6 What Is Gabapentin (Neurontin, Gralise)? Gabapentin was first used to treat seizures (fits, convulsions), so it is sometimes called an anticonvulsant or an antiepileptic. Now it is also used for behavioral problems or bipolar disorder whether or not the patient has seizures. In studies, gabapentin doses for anxiety range from 300 mg to 3,600 mg daily. This is similar to gabapentin dosages used for other conditions. Higher doses are generally divided into three doses a day. Whether you’re already taking gabapentin for an anxiety disorder or are curious if you might benefit from it, you may be wondering how effective it is, how it works, and if there are side effects. Here we’ll cover everything you need to know about gabapentin for anxiety. What is Gabapentin? Although evidence is limited, some studies show gabapentin can help with anxiety symptoms. One 2020 review suggests gabapentin may help with different types of situational anxiety, Anxiety: Anti-anxiety Medications: alprazolam: Xanax: If a child’s anxiety is generalized, the doctor is likely to prescribe an SSRI (see above). If anxiety is specific or occasional-for example, occurring only at school-the doctor might opt to prescribe an antianxiety drug or a beta blocker instead. beta blocker: Propranolol: diazepam There is mounting evidence that Gabapentin may be an effective intervention for various types of anxiety including: generalized anxiety disorder, social anxiety disorder, and panic disorder. There is considerable research documenting the efficacy and safety of Gabapentin for anxiety disorders. Gabapentin users with GAD have been demonstrated to have fewer irritable episodes, cut back on alcohol use as a self-medication, also experience fewer symptoms of depression, feel less anxious when thinking about the future, and improve their phobic avoidance (going out in public more often). label add-on trial in 32 children (ages 2-16 years) with refractory partial seizures.4 The children were treated with gabapentin doses of 10 to 50 mg/kg/day, with an average effective dose of 26.7 mg/kg/day. Eleven children (34%) had a 50% or greater reduction in seizure frequency during treatment. Another 4 children had at least a 25% reduction. Anxiety In Children. When anxiety symptoms are reported with gabapentin, they are more strongly associated with children rather than adults. There is a strong warning of 'neuropsychiatric adverse events ' in children described in the prescribing information for Neurontin, the brand name for gabapentin: Gabapentin may cause drowsiness, which is increased when used with other medicines that cause drowsiness. Any dose change must be guided by your doctor. Gabapentin should be decreased slowly over at least a week. Stopping gabapentin suddenly can cause withdrawal symptoms (anxiety, difficulty sleeping, nausea, pain, sweating or seizures). Gabapentin isn’t usually used to treat anxiety alone. More often, it’s given to ease anxiety symptoms for someone who also has depression or bipolar disorder. (Anxiety is commonly
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