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Gabapentin . Gabapentin is a recent addition to the human anti-convulsant market, which has primarily been used as an adjunctive drug for humans with uncontrolled partial seizures with and without secondary generalization. Gabapentin is well absorbed from the duodenum in dogs with maximum blood levels reached in 1 hour after oral administration. Gabapentin has many useful properties for treating cats beyond use as an anticonvulsant. It is used off-label in cats to reduce situational anxiety, provide pain relief, and is the preferred treatment for a condition called feline hyperesthesia syndrome. In cats, gabapentin is most often used as a pain medication for chronic pain, such as from arthritis. Gabapentin is also recognized as beneficial in reducing the fear responses that a kitty may have to the stress of handling and being examined at the vet. Each cat should have the opportunity to play with the owner or with another cat if desired. Each cat should be able to move freely about its home, including climbing if desired. Scratching posts should be available. Toys should be regularly rotated/replaced. Each cat should be able to choose warmer and cooler areas within the home. During the first portion of the in vivo phase, transdermal gabapentin was applied to the ears or cervical skin of healthy cats at concentrations of 5 or 10 mg/kg every 8 hours. Eight cats were enrolled in this phase. Blood samples were collected 1 and 5 days after collection. Gabapentin was detected in all samples at both time points. In smaller cats, other methods of providing analgesia should be sought as it is not recommended to cut patches in half and covering half of the patch gives unpredictable results. The decay in plasma levels following patch removal is slow. Adapted from: Lascelles D. Relief of chronic pain in cats and dogs: multimodal drug therapy. For mild to moderate fear and anxiety in dogs, trazodone, clonidine, benzodiazepines (e.g. alprazolam, diazepam, lorazepam), gabapentin, imepitoin or dexmedetomidine oromucosal gel might be effective for car ride anxiety, veterinary visits and procedures. 3 In cats, gabapentin, trazodone and benzodiazepines (e.g. lorazepam, alprazolam) can be Despite undergoing some hepatic metabolism in dogs, there is no appreciable induction of hepatic microsomal enzymes in this species. The t ½ for gabapentin in dogs and cats is between 3 and 4 hrs. The recommended dose range of gabapentin for dogs is 25–60 mg/kg body weight, divided, q 6–8 hrs. I use an initial dose regimen of 10 mg/kg body These (e.g., amitriptyline, dogs: 1–2 mg/kg orally q 12–24 h; cats: 2.5–12.5 mg/cat orally q 24 h, gabapentin [see above] may be beneficial as a home medication in combination with those listed above, as the descending inhibitory system appears to be dysfunctional in neuropathic states. The authors sought to evaluate the use of gabapentin in osteoarthritic cats by measuring its effect on patient activity levels, as well as owner-perceived mobility impairment and quality of life. The study was designed as a blinded, placebo-controlled, randomized, crossover study. This study set out to investigate the effect of giving a single dose of gabapentin for fear-based aggressive behaviors in cats during veterinary visits. The researchers compared a dose of either 100 or 200 mg/cat to placebo capsules 2 hours prior to the vet visit. In a 2017 quick poll by the Veterinary Information Network, an online community for the profession, 81% of 2,064 respondents said they prescribed gabapentin in some way for acute pain management. When the same poll question was asked in 2024, the number had risen to 93% of 2,779 respondents. Brand Name: Neurontin. Available in 100 mg, 300 mg, and 400 mg capsules; 600 mg and 800 mg tablets; and oral solution (some products not appropriate for dogs) In dogs, pharmacokinetics of amantadine revealed that the drug seems to be well absorbed, with a short half-life (5 hours after 30 mg/kg PO). 9 In cats, pharmacokinetics of amantadine (5 mg/kg PO and IV) revealed high oral bioavailability and also a short half-life (5.5 hours after 5 mg/kg PO). 10 For this reason, some authors suggest that One study of long-term use of gabapentin as an adjunct drug in 3 cats with chronic pain (average dose 6.5 mg/kg BID) concluded that satisfactory pain management was achieved. Polysulfated glycosaminoglycan (Adequan) is said to have both chondroprotection and chondrostimulation properties. Gabapentin is usually used to manage chronic pain, especially nerve-related pain. It is also used (primarily in cats) to relieve anxiety associated with veterinary procedures, travel, and other fear-generating situations. Gabapentin can also be used as an additional medication in seizure management.
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