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The objective of the current review was to update the previous evidence-based medicine review of treatments for restless legs syndrome published in 2008. All randomized, controlled trials (level I) w This updated review showed that RLS is two to three times more common in patients with CKD compared to the general population. More patients with CKD-A-RLS demonstrated increased mortality, increased incidence of cardiovascular accident, depression, insomnia and impaired quality of life than those w Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology: a report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4(2):101-11914592341PubMed Google Scholar Crossref In vitro and in vivo studies have demonstrated that gabapentin enacarbil has improved absorption, bioavailability and pharmacokinetics compared with gabapentin. Phase II and III studies have demonstrated that gabapentin enacarbil is generally well tolerated and is useful in the treatment of RLS. To request a copy of the clinical practice guideline, “Treatment of restless legs syndrome and periodic limb movement disorder,” or the systematic review, meta-analysis, and GRADE assessment, or to arrange an interview with Dr. Winkelman or an AASM spokesperson, please contact the AASM at media@aasm.org. Accepted papers, which are published Gabapentin is an anticonvulsant shown to alleviate symptoms of RLS in two small studies of nonhemodialysis patients. Because it is excreted renally, gabapentin has a long half-life among In double-blind, multicentre trials, treatment with gabapentin enacarbil 600 mg/day for 12 weeks significantly improved the symptoms of moderate to severe primary RLS in adults. Gabapentin enacarbil also significantly improved RLS pain scores and generally improved sleep and mood outcomes. Gabapentin and pregabalin can improve symptoms of restless legs syndrome. A 2017 meta-analysis of 35 studies of various drugs used for restless legs syndrome suggested pregabalin and gabapentin enacarbil * were equally effective. Background: Restless legs syndrome (RLS) is common among patients with end-stage kidney disease (ESKD) and is associated with poor outcomes. Several recently published studies had focused on pharmacological and non-pharmacological treatments of RLS, but an updated meta-analysis has not been conducted. The FDA approved gabapentin enacarbil in 2011 as the first non-dopaminergic agent for the treatment of restless legs syndrome (RLS) symptoms. Although gabapentin enacarbil is a pro-drug of gabapentin, its pharmacokinetics differ. Introduction. The definition and classification of chronic kidney disease (CKD) have evolved over time. The current international guidelines define this condition as decreased kidney function characterized by a glomerular filtration rate (GFR) of less than 60 ml/min per 1·73 m², or markers of kidney damage, or both, of at least 3 months duration, regardless of the underlying cause. This network meta-analysis supports that gabapentin is the most effective treatment for RLS in ESRD patients. Exercise plus dopamine agonist is a favorable combination therapy concerning side effects. Treatment of restless legs syndrome: evidence-based review and implications for clinical practice (revised 2017). Mov Disord. 2018;33(7):1077–1091. Crossref Google Scholar; 27. Allen RP, Bharmal M, Calloway M. Prevalence and disease burden of primary restless legs syndrome: results of a general population survey in the United States. Gabapentin for restless legs syndrome: a systematic review. Chinese Journal of Evidence-Based Medicine 2012; 12(6): 727-733. Available from: This systematic review provides supporting evidence for the accompanying clinical practice guideline 1 on the treatment of restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) in adults and children. Treatment of restless legs syndrome: evidence-based review and implications for clinical practice (revised 2017). Mov Disord. 2018;33(7):1077–1091. Crossref Google Scholar; 27. Allen RP, Bharmal M, Calloway M. Prevalence and disease burden of primary restless legs syndrome: results of a general population survey in the United States. Gabapentin enacarbil, 1200 mg, maintained improvements in RLS symptoms compared with placebo and showed long-term tolerability in adults with moderate to severe primary RLS for up to 9 months of treatment. Objective: To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS). Methods: Patients with RLS (22 idiopathic, 2 secondary to iron deficiency) were randomized and treated for 6 weeks with either gabapentin or placebo. Systematic Review YASAMAN SAFARPOUR NOSRATOLA D. VAZIRI BAHMAN JABBARI ABSTRACT Objectives: The objective of this review is to provide updated information on the . epidemiology, correlating factors and treatment of chronic kidney disease associated restless legs syndrome (CKD-A-RLS) in both adult and pediatric population. Materials and Methods: Nine patients with idiopathic restless legs syndrome (RLS) were treated with 300 mg of gabapentin as an initial dose and an up-titration until relief of symptoms for 4 weeks. Subjective symptoms improved significantly.
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