The U.S. Food and Drug Administration (FDA) has approved menopausal hormone therapy for moderate to severe vasomotor symptoms and moderate to severe vulvar and vaginal atrophy. Gabapentin 300 mg/day could be useful to relieve hot flashes in women for whom hormone therapy is not suitable or when hot flashes do not respond to other therapies. Further researches are needed to determine the efficacy of gabapentin use for longer periods or at higher doses. Systemic estrogen hormone therapy (HT), with or without progestin, is the most effective therapy for menopause-related vasomotor symptoms, with evidence from multiple studies supporting the Hormone therapy. Estrogen is the main hormone healthcare professionals prescribe to ease hot flashes. Most people who have had their uteruses removed, called a hysterectomy, can take estrogen alone. But those who still have a uterus most often need to take progesterone with estrogen. The mainstay of treatment includes hormonal replacement therapy, selective serotonin, and norepinephrine reuptake inhibitors in addition to lifestyle modification. In this review, we address common issues related to menopause HFs and suggest a stepwise approach to their management. K EYWORDS: Hormone replacement therapy, hot flashes, menopause While hormone replacement therapy is a common treatment, some women seek alternatives. Gabapentin, traditionally used for nerve pain, has emerged as a promising option for managing menopausal symptoms. Hormone therapy is a medical treatment that can help relieve the symptoms of menopause and perimenopause. Hormone therapy also is called “hormone replacement therapy” or “menopausal hormone therapy.” What are the different types of hormone therapy? Estrogen only. Estrogen is the primary hormone used in hormone therapy. Systemic estrogen hormone therapy (HT), with or without progestin, is the most effec-tive therapy for menopause-related vasomo-tor symptoms, with evidence from multiple studies supporting Till date hormone replacement therapy is the only Food and Drug Administration (FDA) approved treatment for postmenopausal symptoms, but recent primary and secondary prevention trials show associated increased risk of coronary disease, thromboembolism, and stroke. Gabapentin is a non-hormonal treatment that may be prescribed for women who need to or want to avoid hormone replacement therapy (MHT). Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. Gabapentin 600-2400 mg/day in divided doses may be a viable option for treating hot flashes in menopausal women who do not want to use hormone replacement therapy. Gabapentin (Gralise, Neurontin). Gabapentin is approved to treat seizures, but it also has been shown to help reduce hot flashes. This medicine is useful for people who can't use estrogen therapy and for those who also have nighttime hot flashes. Clonidine (Catapres-TTS-1, Nexiclon XR). This pill or patch most often treats high blood pressure. Tibolone is a synthetic drug, and its metabolites have properties similar to estrogen, androgen, and progesterone. 38 Compared to hormone replacement therapy, studies have found that there is a lower incidence of uterine bleeding with tibolone. 38 Relative to VMS, most studies show that its efficacy is comparable to hormone replacement therapy of hormone-sensitive breast cancer, endometrial cancer, and endometrioid ovarian cancers.3 Potential alternatives in these cases include gabapentin, pregabalin, clonidine, and venlafaxine, and can be started in primary care following a risk versus benefit discussion. KEY CONSIDERATION 2: WHAT PREPARATION AND REGIMEN ARE REQUIRED? "Menopausal hormone therapy" (MHT) is the term used to describe the two hormones (estrogen and progesterone) that are often given as a treatment to relieve menopausal symptoms. For people whose uterus has been removed (ie, who have had a hysterectomy), estrogen alone can be given. Menopausal hormone therapy containing estrogen is effective for treating vasomotor symptoms of menopause. 7, 8, 12 Unopposed estrogen is known to increase the risk of endometrial cancer and should Hormone therapy for menopause. Menopausal hormone therapy is the most effective tool for treating hot flashes and night sweats associated with menopause. It also can help to prevent osteoporosis. "This new medication shouldn't replace hormone therapy," says Dr. Kling. "Hormone therapy remains the most effective treatment for hot flashes and The WHI was designed to look at the safety of hormone replacement therapy in healthy postmenopausal women with primary outcomes including invasive breast cancer and coronary heart disease (nonfatal myocardial infarction and coronary heart disease death) (Rossouw, 2002). The average age of women in the WHI was 63, and hormone therapy was The “timing hypothesis” suggests that starting hormone therapy early in menopause (compared with starting it 10 years or more after the onset of menopause) may be cardioprotective because of Hormone replacement therapy (HRT) While there are some concerns about HRT, it is still considered the primary treatment for menopause. Oral estrogen and estrogen creams are the first line of treatment for menopause symptoms but may increase your risk of blood clots and breast cancer.
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