Maternal use of gabapentin, particularly late in pregnancy, was associated with a higher risk of PTB, SGA, and NICUa. Gabapentin (Neurontin) is an antiepileptic drug that is now used to treat a wide variety of clinical settings — for the treatment of pain management, restless leg syndrome, anxiety, and sleep disturbance. So far, data regarding the use of gabapentin during pregnancy has been reassuring, and it does not appear that gabapentin. Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. While gabapentin (Neurontin) is now used in a wide variety of clinical settings — for epilepsy, pain management, restless leg syndrome, anxiety, and sleep disturbance – there is relatively little information regarding its reproductive safety. Data on gabapentin use in pregnancy are mixed—some studies suggest it can result in increases in birth defects and other pregnancy complications, while other studies suggest it’s safe. Since decisions about gabapentin use in pregnancy are complex, it’s important to talk with your doctor about whether starting or continuing use is right In a cohort study of pregnant women included in the US Medicaid Analytic eXtract (MAX) dataset, Elisabetta Patorno and colleagues investigate neonatal and maternal outcomes associated with gabapentin exposure during pregnancy. It is not known if gabapentin can make it harder to get pregnant. Sexual dysfunction (including loss of desire to have sex and loss of ability to have an orgasm) has been reported among women who take gabapentin. Despite the fact that gabapentin (Neurontin) is now used in a wide variety of clinical settings -- for epilepsy, pain management, anxiety, sleep disturbance – there is relatively little information regarding its reproductive safety. A prospective study from researchers at the Motherisk program reports on the outcomes of 223 pregnancies exposed to gabapentin and 223 unexposed pregnancies. Advice and warnings for the use of Gabapentin during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out This sheet is about exposure to gabapentin in pregnancy and while breastfeeding. This information is based on available published literature. It should not take the place of medical care and advice from your healthcare provider. Despite the widespread use, only sparse information is available on the safety of gabapentin during pregnancy. We sought to evaluate the association between gabapentin exposure during pregnancy and risk of adverse neonatal and maternal outcomes. Gabapentin may cause side effects such as dizziness, drowsiness, and dizziness. It is important to follow the prescribed dosage and seek medical attention if experiencing serious side effects or changes in mood or behavior. Gabapentin is prescribed by healthcare professionals and should only be taken under medical supervision. Gabapentin use in pregnancy is not very well-studied. While the available information does not strongly suggest that it causes problems for the baby, further research is required to prove that gabapentin is safe. NEURONTIN safely and effectively. See full prescribing information for NEURONTIN. NEURONTIN ® (gabapentin) capsules, for oral use NEURONTIN ® (gabapentin) tablets, for oral use NEURONTIN ® (gabapentin) oral solution Initial U.S. Approval: 1993 ----- Warnings and Pr ecautions, Respiratory Depression (5.7) 04/2020 We have data on 223 pregnancy outcomes exposed to gabapentin and 223 unexposed pregnancies. The rates of major malformations were similar in both groups (p = 0.845). There was a higher rate of preterm births (p = 0.019) and low birth weight <2,500 g (p = 0.033) in the gabapentin group. Gabapentin may be used during pregnancy only when the benefits outweigh the potential risks. In animal studies, gabapentin has been shown to increase the risk for fetal malformation, particularly delayed bone formation. Gabapentin and Pregnancy. The use of gabapentin during pregnancy requires careful consideration, as the potential risks and benefits need to be weighed carefully. While gabapentin is generally considered safe for use during pregnancy, there is limited research on its long-term effects on the developing fetus. Gabapentin is a γ-aminobutyric acid analog formally indicated for the treatment of epilepsy and neuropathic pain that is gaining increased popularity. Gabapentin has been historically considered a safe medication, including during pregnancy and lactation, with low reported concerns for misuse and us There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antiepileptic drugs (AEDs), such as gabapentin, during pregnancy. Encourage women who are taking gabapentin during pregnancy to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling the toll free number 1-888-233-2334 or Ohman I, Tomson T. Gabapentin kinetics during delivery, in the neonatal period, and during lactation. Epilepsia 2009;50 (Suppl. 10):108. Abstract. Patorno E, et al. 2020. Gabapentin in pregnancy and the risk of adverse neonatal and maternal outcomes: A population-based cohort study nested in the US Medicaid Analytic eXtract dataset.
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