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The combination of Gabapentin and opioids presents a complex and potentially dangerous interaction. Both are powerful medications, each with its own set of risks, and when taken together, these risks can be amplified. Common Brand Name(s): Lorcet, Lortab, Norco, Vicodin Common Generic Name(s): hydrocodone bitartrate/acetaminophen Pronunciation: hye-droe-KOE-done and a-SEET-a-MIN-oh-fen Drug Classes: opioid A Major Drug Interaction exists between gabapentin and hydrocodone. View detailed information regarding this drug interaction. Applies to: Vicodin (acetaminophen / hydrocodone) and gabapentin Using narcotic pain or cough medications together with other medications that also cause central nervous system depression such as gabapentin can lead to serious side effects including respiratory distress, coma, and even death. Combining gabapentin with hydrocodone might seem appealing due to their different mechanisms of action. Gabapentin’s ability to target nerve pain could complement the opioid’s effectiveness against more generalized or severe pain types. The combination of gabapentin and hydrocodone poses significant risks, including the potential for respiratory depression. As our understanding of these medications and their interactions grows, so does the necessity for education, caution, and appropriate intervention when complications arise. Compare Gabapentin vs Hydrocodone head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin. Drug Interactions Your risk for serious side effects may be higher if you take other drugs with hydrocodone or oxycodone. Make sure your doctor knows about all the medications and supplements you use. There is a moderate interaction between gabapentin and Vicodin (hydrocodone and acetaminophen) and caution is advised when taking them together. While taking them 3 hours apart may lessen the chance of an adverse reaction, the risk still remains. Applies to: Hydrocodone CP (chlorpheniramine / hydrocodone / phenylephrine) and gabapentin Using chlorpheniramine together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Hydrocodone belongs to the group of medicines called opioid analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain. When hydrocodone is used for a long time, it may become habit-forming, causing mental or physical dependence. In our secondary analysis exploring the effect of gabapentin dose, we found that exposure to a moderate (900 to 1,799 mg daily) or high dose (1,800 mg daily or more) of gabapentin was associated with a nearly 60% increased odds of opioid-related death compared to exposure to opioids alone (aOR 1.56, 95% CI 1.06 to 2.28, p = 0.024, for moderate Studies have shown that taking gabapentin and hydrocodone together can be dangerous because the individual risk of opioid-related death increases. One particular study found that the co-prescription of opioids and gabapentin increased participants’ odds of opioid-related mortality by 60%. 1 After matching 1.5 million patients with gabapentin and opioid prescriptions to 2.1 million patients with opioid-only prescriptions, the team discovered that gabapentin with opioids increased risk of OUD or opioid-related overdose by 47% compared to opioid prescription alone. Interactions; FAQ; What is hydrocodone? Hydrocodone is an opioid pain medication. Zohydro ER and Hysingla ER are extended-release forms of hydrocodone that are used for around-the-clock treatment of severe pain. Extended-release hydrocodone is not for use on an as-needed basis for pain. Warnings. Hydrocodone can slow or stop your breathing. Medicines that interact with hydrocodone may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with hydrocodone. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how Serious side effects of hydrocodone. Along with its needed effects, hydrocodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydrocodone: Less common side effects Hydrocodone is a highly selective full agonist of the μ-opioid receptor (MOR). [28] [54] [49] This is the main biological target of the endogenous opioid neuropeptide β-endorphin. [55] Hydrocodone has low affinity for the δ-opioid receptor (DOR) and the κ-opioid receptor (KOR), where it is an agonist similarly. [49]
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