Gabapentin (Neurontin) and Levetiracetam (Keppra) are both antiepileptic medications, but they have some key differences. Gabapentin is used to treat certain seizures and nerve pain, while Levetiracetam is used for various types of seizures, including partial-onset, myoclonic, and generalized tonic-clonic seizures. Learn about the potential interaction between gabapentin and Keppra, two commonly prescribed medications for seizures, and how it can affect their effectiveness and side effects. Drug interactions are reported among people who take Neurontin (gabapentin) and Keppra (levetiracetam). Common drug interactions include pneumonia among females and fall among males. The phase IV clinical study analyzes what interactions people have when they take Neurontin and Keppra, and groups them by gender, age and more. When a medication works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another Compare Gabapentin vs Keppra head-to-head with other drugs for uses, ratings, cost, side effects and interactions. A Moderate Drug Interaction exists between gabapentin and Keppra. View detailed information regarding this drug interaction. Phenobarbital. In comparison to cimetidine, phenobarbital presents the opposite problem when it comes to drug interactions. A commonly prescribed anti-seizure medication, phenobarbital makes the body produce more CYP enzymes, which increases the clearance and decreases the effectiveness of many types of medications, including digoxin, glucocorticoids, amitriptyline, clomipramine, theophylline Keppra Interactions. There are 238 drugs known to interact with Keppra (levetiracetam), along with 4 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 6 are major, 229 are moderate, and 3 are minor. Keppra XR Interactions. There are 238 drugs known to interact with Keppra XR (levetiracetam), along with 4 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 6 are major, 229 are moderate, and 3 are minor. Drug interactions with the newer antiepileptic drugs (AEDs)-Part 2: Pharmacokinetic and pharmacodynamic interactions between AEDs and drugs used to treat non-epilepsy disorders. Clin Pharmacokinet. 2013;52(12):1045–1061. [Google Scholar] 20. Vecht CJ, Wagner GL, Wilms EB. Interactions between antiepileptic and chemotherapeutic drugs. levetiracetam (12.5–100.0 mg/kg) and gabapentin (1.25–25.0 mg/kg) administered either individually or in pairs at fixed-dose ratios as a combination in mitigating posttraumatic nonconvulsive seizures induced by severe penetrating ballistic-like brain injury (PBBI) in rats. Seizures were detected by continuous electroencephalogram (EEG) monitoring for 72 hours postinjury. Animals were Interaction result: Taking Keppra with carbamazepine may raise the risk of carbamazepine side effects, such as vision changes, unsteadiness, dizziness, nausea, or vomiting. Keppra vs Gabapentin: Keppra (levetiracetam) is primarily used to treat seizures, while Gabapentin targets nerve pain and some seizure types. Keppra has fewer drug interactions, but Gabapentin may cause more sedation. Their uses often depend on the specific condition being treated. Drug interactions are reported among people who take Gabapentin (gabapentin) and Keppra (levetiracetam). Common drug interactions include weight decreased among females and asthenia among males. The phase IV clinical study analyzes what interactions people have when they take Gabapentin and Keppra, and groups them by gender, age and more. The lipid solubility of antiepileptic drugs directly affects central nervous system availability. In relation to this, the interactions of gabapentin and levetiracetam with dipalmitoylphosphatidylcholine lipids depending on concentrations were comparatively investigated in the present study. Results: Both levetiracetam (25-100 mg/kg) and gabapentin (6.25-25 mg/kg) significantly reduced PBBI-induced seizure frequency by 44% to 73% and 61% to 69%, and seizure duration by 45% to 64% and 70% to 78%, respectively. However, the two drugs manifested different dose-response profiles. Using gabapentin together with levETIRAcetam may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Drug Interactions: A total of 270 drugs are known to interact with Gabapentin: 28 major drug interactions (148 brand and generic names) 232 moderate drug interactions (1026 brand and generic names) 10 minor drug interactions (52 brand and generic names) A total of 238 drugs are known to interact with Levetiracetam: Common side effects of Neurontin (Gabapentin) and Keppra (Levetiracetam), two medications commonly used to control seizures, can include but are not limited to: - Carbamazepine interactions with other antiseizure medications - Common side effects of antiseizure medications - Rare but serious side effects of antiseizure medications - WHO MEC for potential drug interactions - Phenytoin interactions with other antiseizure medications - Valproate interactions with other antiseizure medications
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