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Product Name Gabapentin Cat No. : AC458020000; AC458020010; AC458020050; AC458020250 CAS No 60142-96-3 Synonyms 1-(Aminomethyl)-cyclohexaneacetic acid; Neurontin Recommended Use Laboratory chemicals. Uses advised against Food, drug, pesticide or biocidal product use. Details of the supplier of the safety data sheet In cases in which gabapentin was determined to be a cause of death, the blood concentrations ranged from 1.1 to 134.0 mg/L. Persons who died of a gabapentin-related drug death were prescribed the drug legitimately 91.4% of the time, with 84.2% of those also having a known prior history of abuse or misuse of prescription medications. Material Name: Gabapentin Oral Solution, 250 mg / 5 mL Dermal LD50 Rabbit >2 g/kg . Potassium sorbate (24634-61-5) Oral LD50 Rat 3200 mg/kg . Carcinogenicity. · Trade name:Gabapentin · Synonym CI-945 1-(aminomethyl)-cyclohexaneacetic acid · Article number:10008346 · CAS Number: 60142-96-3 · EC number: 262-076-3 · Application of the substance / the mixture This product is for research use - Not for human or veterinary diagnostic or therapeutic use. · Details of the supplier of the safety data sheet Gabapentin is an anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Material Name: Gabapentin Tablets (Neurontin) Trade Name: Neurontin® Chemical Family: Mixture Intended Use: Pharmaceutical product used as anticonvulsant 2. HAZARDS IDENTIFICATION Appearance: White, eliptical, film-coated tablets Statement of Hazard: Non-hazardous in accordance with international standards for workplace safety. Additional Gabapentin exhibits antiseizure activity in mice and rats in both the maximal electroshock and pentylenetetrazole seizure models and other preclinical models (e.g., strains with genetic epilepsy, etc.). Gabapentin is a gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome. It has a role as an anticonvulsant, a calcium channel blocker, an environmental contaminant and a xenobiotic. Mouse Oral LD50 > 5000 mg/kg Rat Oral LD50 > 1600 mg/kg Gabapentin Revision date: 08-Nov-2018 Rat Oral LD50 > 5000mg/kg Reproductive & Fertility Rat Oral500 mg/kg/day NOAEL Negative Material Name: Gabapentin Capsules (100 mg, 300 mg and 400 mg) So I am going on a gabapentin binge recently. I know the ld50 is 1000-2000 mg/kg but how safe is a dose of like 3000-4000 mg every other day to every two days for the time being. According to a classification scheme(2), this estimated Koc value suggests that gabapentin is expected to have high mobility in soil. Experimental pKa values for gabapentin are 3.68 (carboxylic acid) and 10.70 (primary amine)(4), indicating that this compound will primarily exist as a zwitterion in the environment. Chemical Book 7 Gabapentin Gabapentin Starch Eye Irritation Rabbit Non-irritating Bacterial Mutagenicity (Ames) Salmonella , E. coli Negative In Vitro Chromosome Aberration Hamster Lung Cells Negative In Vivo Unscheduled DNA Synthesis Rat Hepatocyte Negative Mouse IP LD50 6600 mg/kg Gabapentin The lethal dose of gabapentin has not been determined. In an FDA study, no lethal dose was found in mice and rats receiving doses as high as 8,000 milligrams per kilogram of body weight (mg/kg). A regular dosage of gabapentin for children aged 3 to 11 years is up to 50 mg/kg per day. Gabapentin is an antiepileptic drug that is prescribed for both FDA-approved and multiple off-label conditions, and has a relatively safe side-effect profile. Rare cases of overdose-related adverse effects have been reported in the literature. Mouse IV LD50 1000-2000mg/kg Gabapentin Rat Subcutaneous LD50 > 4000mg/kg Material Name: Gabapentin Tablets (Neurontin) Gabapentin Eye Irritation Rabbit Non-irritating Povidone Mouse Oral LD50 > 5000 mg/kg Gabapentin Rat Oral LD50 100 g/kg Version: 2.1 Rat Oral LD50 12.6 g/kg Gabapentin 52 Week(s) Rat Oral 250 mg/kg/day NOAEL Liver, Kidney Bacterial Mutagenicity (Ames) Salmonella , E. coli Negative In Vitro Chromosome Aberration Hamster Lung Cells Negative 52 Week(s) Monkey Oral 250 mg/kg/day NOAEL None identified Gabapentin overdoses can be dangerous, especially when it’s used alongside other substances. Learn how to avoid a gabapentin overdose and what to do about one. Rat Dermal LD 50 > 21.9 g/kg Revision date: 09-Nov-2018 Mouse IV LD50 1000-2000mg/kg Gabapentin Gabapentin Rat Subcutaneous LD50 > 4000mg/kg Eye Irritation Rabbit Non-irritating Material Name: Neurontin (gabapentin) Oral Solution Glycerin, USP Glycerin, USP Eye Irritation Rabbit Mild Gabapentin prevents pain-related responses in several models of neuropathic pain in rats and mice (e.g., spinal nerve ligation models, spinal cord injury model, acute herpes zoster infection model). Gabapentin or Neurontin is an anticonvulsant and anti-epileptic medication. Healthcare providers often use it to treat partial seizures, postherpetic neuralgia (Gralise), and more. A gabapentin overdose is rare, but it is possible.
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