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Gabapentin initiation was significantly associated with cognitive/functional status decline: worsening CDRGLOB at index+1 visit (odds ratio [95% confidence interval]: 1.55 [1.07, 2.25]); CDR-SB at index+1 visit (1.94 [1.22, 3.09]); and mean of FAQ at index+2 visit (1.78 [1.12, 2.83]). Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. However, the relation between gabapentin initiation and longer-term neurocognitive changes is not well understood. The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Three of 4 patients were successfully titrated to a full dose of 2,400mg/day. These findings suggest a possible role for gabapentin in the behavioral Especially in older adults, gabapentin is prescribed to treat behavioral and psychological symptoms of dementia (BPSD) (Kim et al., 2008). Several studies have reported that gabapentin has a deleterious effect on cognition (Leach et al., 1997; Meador et al., 1999; Shem et al., 2018). AD, VaD, dementia of traumatic brain injury, anoxic brain damage dementia, dementia NOS, alcoholic dementia, Parkinson's dementia: Gabapentin: 1318 mg day −1 average (300–3600 mg day −1) OASa, OASSYb, CMAIc, CGI-Id: 5-very much improved 12- much Improved 4-Minimally Improved 1-Unchanged 2-Dropout: Excessive sedation, 2: 4: Herrmann et al In the study suggesting that there was a dementia risk, it was strongest in younger people. I conclude that you aren’t doomed. Gabapentin was first approved by the United States (US) Food and Drug Administration (FDA) in 1993 to treat partial seizures and additionally approved for postherpetic neuralgia in 2004 (Pfizer, 2017). By 2018, gabapentin was the 6 th most prescribed medication in the US market (IQVIA Institute for human data science, 2019). To explore the association between gabapentin use and the risk of dementia in patients with chronic pain, considering the rising concerns of dementia in an aging population and the potential cognitive impacts of chronic pain management. This large, robust study showed a definite link between anticholinergic medications and patients who have dementia, but it didn’t prove that there was a direct cause. Heartburn medications: Some recent studies, including one from 2022 published in BMC Medicine, have found a link between medications commonly used to treat gastroesophageal reflux disease (GERD), heartburn and peptic ulcers with an increased risk of dementia. If you take an over-the-counter proton-pump inhibitor, Garling-Nañez says it’s Although previous studies have established a link between chronic pain and elevated risk of cognitive dysfunction, including dementia (Kao et al., 2021; Chen et al., 2023; Cao et al., 2019), the literature is sparse on gabapentin's potential role in dementia onset. The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Three of 4 patients were successfully titrated to a full dose of 2,400mg/day. These findings suggest a possible role for gabapentin in the behavioral Moreover, the stratification analysis revealed that the risk of dementia associated with gabapentin or pregabalin exposure was significant in all age subgroups; however, it was higher in younger patients (age <50) than in the older patients (hazard ratio, 3.16; 95% CI, 2.23-4.47). Gabapentin use was significantly associated with decline in cognitive and functional status among older adults with initially normal cognition. Further studies are needed to examine the association. And since treatment options for dementia are limited, prevention is key. Dementia risk is tied to common things like diabetes, high blood pressure, and physical inactivity. But some common medications are associated with dementia risk, too. Here are four common drug classes linked to dementia, and what the research says about your risk. 1. Two common classes of drugs have been linked to dementia. Fortunately, there are alternatives to both. If you're worried about developing dementia, you've probably memorized the list of things you should do to minimize your risk—eating a healthy diet, exercising regularly, getting adequate sleep, and keeping your mind and soul engaged. AEDs in the study included levetiracetam, valproate, clonazepam, topiramate, carbamazepine, lamotrigine, gabapentin, pregabalin, primidone, and others. There was no significant association between any use of AEDs and dementia risk (OR = .99). The duration of AED therapy was also not associated with a risk of dementia (OR = 1.00 per therapy year). The results revealed that the risk of dementia associated with gabapentin or pregabalin exposure was significant in all subgroups except for the strata having depression or head injury. The risk of dementia development was higher in the younger group (age <50 years) than that in the older group. One notable study explicitly found that cumulative exposure to gabapentin and pregabalin was linked to a higher risk of dementia, with individuals under 50 years old and those who received higher accumulative doses being particularly vulnerable. These findings are consistent with other studies that suggest that chronic use of gabapentin might We present the case of a patient with incipient vascular dementia accompanied by nocturnal agitation, which was successfully treated with gabapentin. Gabapentin appears to be useful and well-tolerated in this indication.
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