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Low-dose gabapentin may result in marked sexual dysfunction, including loss of libido, erectile dysfunction, ejaculatory dysfunction, and anorgasmia. Such sexual dysfunction may lead to medication noncompliance. Patients often do not volunteer information regarding sexual dysfunction, and therefore, targeted questions are necessary. We identified 3 studies that described anorgasmia related to gabapentin. 42,46,47 The first described anorgasmia with no change in libido in a 52-year-old patient treated for neuropathic pain related to a thoracotomy scar after uptitration of the gabapentin dose from 300 to 900 mg/d; symptoms resolved after a dose reduction to <900 mg/d. 46 In a study conducted by Rutgers University, Gabapentin improved arousal and satisfaction in women. It provoked a chronic condition causing stinging, itching, and burning at the vaginal entry. It may also cause low libido. Indeed, their psychiatric patient experienced loss of libido, anejaculation/anorgasmia, and erectile dysfunction when treated with gabapentin (GBP) at a daily dose of 300mg, demonstrating how even very low doses of new antiepileptic drugs can cause SD in predisposed individuals. Abstract Background: Sexual dysfunction is common in women with vulvodynia. Objective: 1. To evaluate whether extended-release gabapentin is more effective than placebo in improving sexual function in women with provoked vulvodynia, and if there is a relationship between treatment outcome and pelvic pain muscle severity evaluated by palpation with standardized applied pressure. Traditional AEDs such as valproate and enzyme-inducing AEDs (EIAEDs) may produce high incidences of decreased libido. Recently, sexual function changes related to new AEDs have been reported. Topiramate, pregabalin and gabapentin may cause SD, whereas oxcarbazepine, lamotrigine and levetiracetam may improve sexual function. There is a researched link between sexual dysfunction and some antiepileptic medications, including gabapentin. Sexual dysfunction can appear as erectile dysfunction in some men. It can also cause other sexual performance issues, such as changes in libido (sex drive) and difficulty achieving orgasm. As a result of taking gabapentin, it’s possible for a few different sexual health issues to arise. Some older men have lost the ability to orgasm while taking this prescription medication. While this severe symptom is a pretty rare occurrence, a much more common side effect is erectile dysfunction. Gabapentin helps me sleep, I take 800mg at night. It has seriously affected increased my libido and has become a problem. I am a 55 year old female who still has regular periods, and both ovaries, but I need to have a decreased libido and try something different for sleep. Low-dose gabapentin may result in marked sexual dysfunction, including loss of libido, erectile dysfunction, ejaculatory dysfunction, and anorgasmia. Such sexual dysfunction may lead to medication noncompliance. Patients often do not volunteer information regarding sexual dysfunction, and therefore, targeted questions are necessary. This report addresses dose-dependent gabapentin-induced sexual dysfunction reaching total sexual dysfunction (loss of libido, anejaculation, anorgasmia, and impotence) at a total daily dose of only 300 mg. While taking 300 mg of gabapentin 3 times per day, he noticed orgasm was more difficult to attain. Neither libido nor erection was affected. Gabapentin reduced his hypomania, but as the dose increased, he found ejaculation and orgasm increasingly difficult to achieve. But they’re possible and include decreased sex drive (libido) and trouble getting or keeping erections (erectile dysfunction). If you’re taking gabapentin and experiencing sexual problems, talk with your prescriber. They can help you determine if gabapentin is the cause or if it’s something else. For women, the study found that the opioids hydrocodone, oxycodone, and morphine had no impact on free estrogen levels, while tramadol, fentanyl, and gabapentin significantly reduced levels of free estrogen. In a small study, researchers at Rutgers University found that gabapentin improved sexual desire, arousal and satisfaction in 89 women with provoked vulvodynia, a chronic condition characterized by stinging, burning and itching at the entry to the vagina. Low-dose gabapentin may result in marked sexual dysfunction, including loss of libido, erectile dysfunction, ejaculatory dysfunction, and anorgasmia. Such sexual dysfunction may lead to medication noncompliance. Additionally, gabapentin-induced anorgasmia and reduced libido were also reported in two women who were both taking 900 to 1,800 mg of gabapentin. In one case, symptoms disappeared with dose reduction, but in the other, the drug had to be stopped altogether. 3 They occurred with low therapeutic PGB doses (50-100 mg/d). Discontinuation of PGB resulted in improvement of SDs within weeks. To conclude, SDs are not infrequent adverse effects of PGB therapy. Pregabalin can induce erectile dysfunction, loss of libido, and anorgasmia. Sexual dysfunctions induced by PGB are not dose related. Gabapentin, frequently used off-label to treat psychiatric and pain disorders, has previously been reported to cause sexual dysfunction at a minimum total daily dose of 900 mg. This report addresses dose-dependent gabapentin-induced sexual dysfunction reaching total sexual dysfunction (loss of libido, anejaculation,
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