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We retrospectively analyzed the medical records of 240 dogs taking gabapentin for chronic pain and systematically assessed: patient signalment, definitive diagnosis, location and description of pain, VAS scores immediately preceding and following the patient’s maximum gabapentin dose, Several case reports note analgesia when gabapentin was used for treatment of chronic pain. 14,15 And in a clinical study on postoperative pain in dogs undergoing mastectomy, although pain scores did not differ, dogs receiving NSAIDs plus gabapentin required fewer opioid rescue doses than dogs receiving NSAIDs alone; thus, the gabapentin did Summary: This paper describes the pharmacokinetic studies of 1-(aminomethyl)-cyclohexane acetic acid (gabapentin, Go 3450, CI-945) conducted with the '4C-labelled substance fal-lowing intravenous and intragastric administration to rats and dogs and oral administration to humans. Gabapentin exceeded 2 μg/mL in the 20 mg/kg dose group in 6/6 dogs at 8 h, and 2/6 dogs at 12 h after dosing. These data suggest 10–20 mg/kg every 8 h would maintain 2 μg/mL plasma concentrations in dogs. This review aimed to clarify gabapentin use and pharmacokinetic aspects to promote conscious use in dogs, cats, and horses. In dogs, gabapentin was beneficial in the treatment of epilepsy, as well as chronic, neuropathic, and post-operative pain, as well as anxiety. dogs were administered gabapentin twice daily, whereas the remaining 10 received gabapentin 3 times daily. The study provided insight into dosing and effect of gabapentin in dogs. In dogs, however, 30–40% of the orally administered dose of gabapentin undergoes hepatic metabolism to N-methyl-gabapentin. Despite undergoing some hepatic metabolism in dogs, there is no appreciable induction of hepatic microsomal enzymes in this species. The t ½ for gabapentin in dogs and cats is between 3 and 4 hrs. The duration of Gabapentin’s effects in dogs can range from several hours to a full day, depending on the individual dog and the specific dosage administered. For most dogs, the effects of Gabapentin typically last for around 6 to 8 hours. In the dog, gabapentin was metabolized to N-methylgabapentin (approximately 34% of dose); whereas metabolism in mouse, rat, and monkey was minimal (< 5%). The principal route of excretion was via urine. Gabapentin is eliminated entirely by renal clearance in people, but there is 30%-40% hepatic metabolism in dogs. Therefore, drugs that affect liver metabolism, or severe liver disease may decrease gabapentin clearance in dogs. In dogs, gabapentin was beneficial in the treatment of epilepsy, as well as chronic, neuropathic, and post-operative pain, as well as anxiety. In cats, it showed efficacy in post-ovariohysterectomy-related pain and in anxiety management. In dogs, however, a remarkable formation of N-methyl-gabapentin is found. Elimination half-lives range between 2-3 h in rats, 3-4 h in dogs, and 5-6 h in man. Gabapentin is nearly exclusively eliminated via the kidneys. Gabapentin is rapidly absorbed and eliminated in both canine and feline patients. 8 Frequent administration is needed to maintain minimum target plasma concentrations. 8 Pharmacokinetic data suggest that gabapentin should be dosed at 10 mg/kg every 8 hours in dogs, 8 and 8 mg/kg every six hours in cats. 9 Gabapentin for dogs is commonly prescribed for pain, anxiety, or seizures. It's generally safe, but there are some known side effects to be aware of. In the dog, gabapentin was metabolized to N-methylgabapentin (approximately 34% of dose); whereas metabolism in mouse, rat, and monkey was minimal (< 5%). The principal route of excretion was via urine. Gabapentin is excreted unchanged in humans but is metabolized to N-methyl-gabapentin in dogs. Results in faster elimination and ability for shorter dose intervals in dogs as compared with humans 2 The metabolism of gabapentin has not been studied in cats, but pharmacokinetics demonstrates faster elimination than in humans, with similar
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