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Abstract. Despite its prevalence and disease burden, several chasms still exist with regard to the pharmacotherapy of bipolar disorder (BD). Polypharmacy is commonly encountered as a significant proportion of patients remain symptomatic, and the management of the depressive phase of the illness is a particular challenge. Recently, clinical and research attention has focused on the use of the new anticonvulsants gabapentin and lamotrigine as alternatives to standard pharmacotherapies for the treatment of mood and anxiety disorders. This paper reviews the experience to date with these agents in the treatment of psychiatric conditions. cording to DSM-IV (292.84)25 as gabapentin-induced mood disorder with mild manic features and onset dur-ing medication. The gabapentin-induced behavioural changes in Gabapentin has clearer efficacy for alcohol craving and withdrawal symptoms and may have a role in adjunctive treatment of opioid dependence. There is no clear evidence for gabapentin therapy in depression, PTSD prevention, OCD, or other types of substance abuse. Some research suggests that gabapentin might have mood-stabilizing properties, potentially helping with conditions like bipolar disorder. It’s like the medication is acting as an emotional shock absorber, smoothing out the highs and lows. Gabapentin is commonly used off-label in the treatment of psychiatric disorders with success, failure, and controversy. A systematic review of the literature was performed to elucidate the evidence for clinical benefit of gabapentin in psychiatric disorders. Mood disorders. Mood disorders are complex conditions that in some individuals can be refractory to FDA-approved pharmacotherapies. American Psychological Association: Gabapentin has been “largely discredited as a mood stabilizer for bipolar disorder.” Depression and Bipolar Support Alliance : Gabapentin “was used frequently for treatment of bipolar disorder, but controlled studies found it was no more effective than a placebo.” Gabapentin is a nerve pain medication and anticonvulsant that has proven to be effective for people who have hard-to-treat depression or other mood disorders. The mainstay of management of bipolar disorder is mood stabilizers. Mood stabilizers (lithium and divalproex) are the first-line treatments for acute mania and mixed episodes, with second-generation antipsychotics (aripiprazole, asenapine, olanzapine, quetiapine, risperidone, and ziprasidone) used for subsequent treatment. But gabapentin’s potential doesn’t stop at anxiety. It’s also making waves in the treatment of mood disorders. While it’s not typically a first-line treatment for depression, some patients with bipolar disorder have found relief from mood swings when gabapentin is added to their treatment regimen. However, relevant research data have not proven success of newer antiepileptics. This article presents the negative side effects of gabapentin such as psychotic and depressive symptoms, which occur shortly after its use. The use of gabapentin in mood disorders is discussed through these side effects. While gabapentin is sometimes used in an attempt to treat mood disorders like depression, there is no clear evidence backed by high-quality studies that supports its effectiveness in this regard. Some reports suggest that gabapentin can exacerbate mood issues and has been linked to depressive symptoms, highlighting a complex relationship Before gabapentin is prescribed the patient should have a thorough medical evaluation, including blood and urine tests, to rule out any medical condition, such as thyroid disorders, that may cause or exacerbate a mood disorder. We conclude that there is moderate evidence of the efficacy of gabapentinoids in anxiety states, but minimal evidence in bipolar disorder and insomnia and they should be used for these The relatively low frequency of bipolar disorder diagnoses in the sample of off-label gabapentin visits suggests that use of gabapentin as a mood stabilizer has declined, which corresponds with more recent psychopharmacology literature concluding that gabapentin’s mood-stabilizing effects are minimal to negligible (13, 32). We found few Objective: To determine if gabapentin is effec-tive either as adjunctive treatment or as mono-therapy for major affective disorders in a natural-istic setting. Gabapentin, a medication that sounds like it could be the name of a quirky robot sidekick in a sci-fi flick, is actually a serious player in the world of pain management and neurological disorders. Originally developed to treat epilepsy, this versatile drug has found its way into the treatment plans for conditions ranging from neuropathic pain Objective: Gabapentin is commonly used off-label in the treatment of psychiatric disorders with success, failure, and controversy. A systematic review of the literature was performed to elucidate the evidence for clinical benefit of gabapentin in psychiatric disorders. Lithium and gabapentin. Gabapentin is currently being studied as a treatment for bipolar disorder, and there have been favorable reports regarding its potential as a mood stabilizer (82, 83). The advantages of gabapentin include the lack of interactions with other drugs in the cytochrome P450 system and the lack of protein binding . Since there
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