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Our goal was to compare the effects of gabapentin and pregabalin on improving sleep quality and depression among hemodialysis patients with PPN. Methods: Fifty hemodialysis patients with PPN were randomized into 2 groups, to receive gabapentin and pregabalin, respectively. After 6 weeks of treatment, patients underwent a 2-week washout period Compared with the placebo group, the gabapentin group showed significant improvement in sleep quality (P < 0.001), next-day functioning (P < 0.001), number of nighttime awakenings caused by RLS symptoms (P = 0.043), and number of hours awake due to RLS symptoms (P = 0.019) after 12 weeks of treatment; the gabapentin group had a significantly Introduction. Sleep disorders have been always a disturbing public health issue, not only because they affect quality of life, increase the patient’s risk of cardio-cerebrovascular disease (1, 2) and death (2, 3), weaken social productivity, and increase medical burdens (4, 5) but also because unlike other diseases with a phase-wise pattern, they cannot be cured using multiphase treatment. The potential synergistic effects of gabapentin on sleep quality when used for both sleep and anxiety are particularly interesting. By reducing anxiety levels, gabapentin may help create a more relaxed state conducive to falling asleep and staying asleep throughout the night. Chronic neuropathic pain (NP) is debilitating and impacts sleep health and quality of life. Treatment with gabapentinoids (GBs) has been shown to reduce pain, but its effects on sleep health have not been systematically evaluated. The objective of this systematic review and meta-analysis was to asse Gabapentin is a prescription drug used to treat insomnia. Studies show it can increase the amount of deep sleep you get at night and improve your sleep quality. Gabapentin is considered highly effective for the treatment of insomnia for a few reasons. First and foremost, it improves sleep quality by reducing spontaneous arousal in the brain. It also increases total sleep time thanks to fewer awakenings and its ability to help individuals go to sleep faster. Gabapentin was associated with less %stage1 on Day 1, and greater %REM on Day 28, versus placebo. During home use, gabapentin resulted in significantly less participant-reported WASO and higher ratings of sleep quality. Gabapentin was well tolerated (most common adverse events: headache, somnolence) with no evidence of next-day impairment Gabapentin appears to have a multifaceted impact on this sleep structure, potentially enhancing certain aspects of sleep quality. Research suggests that gabapentin may increase slow-wave sleep, also known as deep sleep, which is crucial for physical recovery and memory consolidation. Preliminary evidence indicates that gabapentin can attenuate insomnia, bolster sleep quality, and increase total sleep duration. Moreover, gabapentin has been shown to increase slow-wave sleep (SWS), promote sleep maintenance, and decrease unwanted awakenings throughout the night. Gabapentin enhances slow-wave sleep in patients with primary insomnia. It also improves sleep quality by elevating sleep efficiency and decreasing spontaneous arousal. The results suggest that gabapentin may be beneficial in the treatment of primary insomnia. These conditions can severely disrupt sleep quality and often lead to insomnia. Gabapentin’s ability to modulate nerve signaling may help alleviate the uncomfortable sensations associated with RLS and reduce the frequency of limb movements during sleep. Furthermore, some patients report improvements in overall sleep quality when taking Objective: The aim of this research was to analyze gabapentin's effect on Pittsburgh Sleep Quality Index (PSQI) scores in menopausal women. Methods: Secondary analysis of data from a cohort of menopausal women participating in a randomized, double-blind, placebo-controlled trial of gabapentin 300 mg three times daily (TID) for hot flashes. Gabapentin is safe and effective in improving the sleep quality of patients with sensory nervous-system diseases. Due to the limitations of sample size and types of diseases in the current study, the field needs multicenter, large-sample, and high-quality RCTs for further validation in the future. It is known to have analgesic and antidepressive effects. 7, 8, 9 Melatonin is a relatively non-toxic drug and several times it has been used for sleep disturbances of both adults and children with no reported serious side effects. 10, 11, 12 However, the effect of melatonin on the “day time sleepiness” side effect of gabapentin and Gabapentin, an α 2 δ subunit ligand of L-type voltage-gated calcium channels, is indicated for the management of postherpetic neuralgia and restless legs syndrome, and as adjunctive therapy for partial seizures with and without secondary generalization (maximal dose: 600-1800 mg/day depending on indication and gabapentin formulation). 8 –10 Gabapentin is a medication that can aid in improving sleep quality and reducing insomnia symptoms, allowing us to achieve the restful and rejuvenating sleep our bodies and minds need. Benefits. When it comes to improving sleep quality, Gabapentin offers a range of benefits. Some research shows gabapentin may be effective for sleep. But it comes with risks, including dizziness, falls, and fluid buildup. Gabapentin is a controlled substance in some states. Gabapentin and sleep. Most studies show that gabapentin improves slow wave sleep (“deep sleep”) and total sleep time. Two small studies showed that gabapentin may help people with primary insomnia and occasional sleep disturbance improve total sleep time and wakefulness in the morning.
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