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We would like to show you a description here but the site won’t allow us. The New Zealand Formulary. The NZF is an independent resource providing healthcare professionals with clinically validated medicines information and guidance on best practice, enabling healthcare professionals to select safe and effective medicines for individual patients. %PDF-1.7 %µµµµ 1 0 obj >/Metadata 357 0 R/ViewerPreferences 358 0 R>> endobj 2 0 obj > endobj 3 0 obj >/ExtGState >/Font >/ProcSet[/PDF/Text/ImageB/ImageC/ImageI Gabapentin is also used to treat neuropathic pain, a type of pain caused by damage to the nerves. This medicine belongs to a group of medicines called anticonvulsants. How Gabapentin works The number of people in New Zealand with neuropathic pain is unknown; worldwide it is estimated to affect 7% of people. The prevalence of neuropathic pain is predicted to rise due to an ageing population, increased cancer survival and chemotherapy-induced neuropathy, and an increased prevalence of diabetic neuropathy.2 Gabapentin is indicated for the treatment of neuropathic pain (see section 4.2). Adults and Children Older than 12 Years of Age Initiation of treatment should be as add-on therapy. Gabapentin can be given orally with or without food. From mid-2018 clinicians in primary care will have more prescribing options for patients with neuropathic pain. Tricyclic antidepressants (TCAs), gabapentin or pregabalin (see: “What is pregabalin”) are recommended first-line medicines for patients with neuropathic pain. 1, 2 * TCAs used to manage neuropathic pain, such as amitriptyline and nortriptyline, are fully subsidised without Gabapentin and pregabalin, known as gabapentinoids, are funded in New Zealand for use in people with neuropathic pain and for seizure control in some people with epilepsy The Spotlight series continues with this article on gabapentin and pregabalin, collectively known as gabapentinoids. They are anticonvulsant medicines but also have analgesic and anxiolytic actions. 1 This article focuses on the use of gabapentinoids for neuropathic pain. Gabapentin is used to treat and prevent some types of pain and seizures. It is also sometimes used for other conditions. Tell your doctor if you have kidney problems. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. How should you take it? Take gabapentin regularly as directed with a glass of water. Information for parents and carers about the use of gabapentin for neuropathic pain (pain caused by nerve damage). For free medical advice call Healthline 0800 611 116. Healthline provides a 24 hour, 7 days a week, over-the-phone health service. For emergencies call 111. Gabapentin is used to treat some types of nerve pain and epilepsy and prevent migraine headaches. Find out how to take it safely and possible side effects. Gabapentin is also called Neurontin or Nupentin. Gabapentinoids are an efective treatment for post-herpetic neuralgia and painful diabetic neuropathy; there is increasing evidence that they are not efective for people with sciatica or non-specific low back pain. There is also growing concern of a rise in gabapentinoid misuse and dependence. What are gabapentinoids? Response to dose reduction will vary considerably between patients, depending on their starting dose and duration of use, but in general a dose reduction step should usually not exceed: 50 – 100 mg pregabalin in one week; 300 mg gabapentin in one week Gabapentin’s has non-linear bioavailability and so bioavailability reduces with higher dosages. Pregabalin has linear bioavailability. The information contained within this bulletin is to be used in conjunction with the diagnostic and clinical skills of the general practitioner. The information in this bulletin is compiled from a number of sources. be dosed three to four times daily. To reduce troublesome adverse effects that can occur upon initiation (eg somnolence, dizziness, and ataxia), start with an evening dose,1 and then gradual. y up-titrate the dose as tolerated. It may take up to . Table 1: Dosage of gabapentin in paediatric patients age 3-12 years Weight range (kg) Daily dose (mg/day) 17 – 25 600 26 - 36 900 37 - 50 1200 Unlike other agents in this class, it is not necessary to monitor gabapentin plasma concentrations to 51 - 72 1800 optimise gabapentin therapy. Further, gabapentin may be used in combination with other Gabapentin Medsurge may lead to dependence on this medicine. Ask your doctor if you have any questions about why Gabapentin Medsurge has been prescribed for you. This medicine is available only with a doctor's prescription. Use in children history of drug abuse and/or There is not enough information to recommend the use of this medicine in NEURONTIN is indicated for the treatment of neuropathic pain (see section 4.2 Dose and method of administration). Adults and Children Older than 12 Years of Age Initiation of treatment should be as add-on therapy. Gabapentin can be given orally with or without food. Dosage of gabapentin. The use of gabapentin for neuropathic pain/pruritus is recommended only in patients over 18 years of age. The starting dose is 900mg/day (given as 300mg 3 times daily) and increased if necessary based on response. The maximum daily dose is 3600mg. Dosage may need to be adjusted in those with impaired renal function
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