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These can affect fertility, sexuality, thyroid function, and bone health, all functions of major importance for well-being and quality of life. The liver enzyme inducing antiepileptic drugs (EIAEDs), like phenobarbital, phenytoin, and carbamazepine, and also valproate (VPA), a non-EIAED, are most likely to cause such side effects. Valproate may be a mild inducer of CYP3A4, and levetiracetam may interact with DOACs through an unknown mechanism, but product monographs do not address these potential interactions. Using valproic acid together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. interactions, and oxcarbazepine, lamotrigine, felbamate and, at high dosages, topira-mate may stimulate the metabolism of oral contraceptive steroids. Levetiracetam, gabapentin and pregabalin have not been reported to cause or be a target for clinically relevant pharmacokinetic drug interactions. Pharmacodynamic interactions involving Compare Gabapentin vs Valproate Sodium head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Valproate and gabapentin. Valproate and gabapentin in combination require further study, as few data are currently available. These agents appear to be safe together and to have no major interactions, and no adverse reactions have been reported . Hence, no dose adjustment or additional serum blood level monitoring is indicated. Use the interactions A to Z to look up a drug and see which other drugs it interacts with and the severity of these interactions. The patients had been exposed to a total of eight different types of AEDs. Sodium valproate was the most common drug (29, 38%), followed by lamotrigine (22, 29%), gabapentin (16, 21%), pregabalin (seven, 9%), topiramate (five, 7%) and carbamazepine (two, 3%). There has been one case each with phenytoin and oxcarbazepine. Gabapentin, levetiracetam, pregabalin, tiagabine, valproate, vigabatrin and zonisamide have been reported not to interact with steroid oral contraceptives. Benzodiazepines and ethosuximide are also considered not to interact [ 2 , 12 ]. Valproic acid undergoes drug-drug interactions with most of the commonly used anti-convulsants. Since it possesses a wide range of indications, concomitant use with other anticonvulsants, and hence interactions, are not infrequent. Many of these interactions are reciprocal and may have important therapeutic consequences.Valproate acts as a protein binding displacer and/or metabolic inhibitor Many of the interactions depend on the induction or inhibition of the cytochrome P450 isoenzymes, but other important mechanisms involve the uridine diphosphate glucuronosyltransferase isoenzymes and protein binding. There is some evidence for the following effects. No interactions between gabapentin and valproate, carbamazepine or lithium have been reported. Does gabapentin interact with any other prescriptions or over-the-counter medications, such as Gabapentin, levetiracetam, pregabalin, tiagabine, valproate, vigabatrin and zonisamide have been reported not to interact with steroid oral contraceptives. Benzodiazepines and ethosuximide are also considered not to interact [ 2, 12 ]. 411 medications are known to interact with valproic acid. Includes gabapentin, aspirin, carvedilol. Valproate Sodium Interactions. There are 411 drugs known to interact with Valproate Sodium (valproic acid), along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 24 are major, 363 are moderate, and 24 are minor. Carbamazepine and gabapentin. As with valproate, the coadministration of carbamazepine with gabapentin appears safe, with no significant interactions . Hence, dose adjustments and additional blood level monitoring are not necessary. Potential Effects of Sodium Valproate and Gabapentin Interaction. When Sodium Valproate and Gabapentin are taken together, there are potential effects that individuals should be aware of. It is important to note that these effects may vary from person to person, and not everyone will experience them. 1. Increased Sedation: Drug interactions are reported among people who take Gabapentin (gabapentin) and Valproate sodium (valproate sodium). Common drug interactions include stress among females and increased appetite among males. While sharing a common property of suppressing seizures, antiseizure medications have many different pharmacologic profiles that are relevant when selecting and prescribing these agents in patients with epilepsy and other conditions. Back DJ, Bates M, Bowden A, et al. The interaction of phenobarbital and other anticonvulsants with oral contraceptive therapy. Contraception. 1980;22(5):495-503. Sonnen AEH. Sodium valproate and
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