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Gabapentin, often prescribed for nerve pain, seizures, and other conditions, can interact with a range of other medications, sometimes leading to adverse effects. It’s essential to be aware of these potential interactions to ensure safe and effective treatment. More than a quarter of the experts considered the following combinations to be contraindicated: clozapine + carbamazepine (rated as contraindicated by 39% of the experts), ziprasidone + a tricyclic antidepressant (TCA) (rated as contraindicated by 26%), and a low-potency conventional antipsychotic + fluoxetine (rated as contraindicated by 27%). Find patient medical information for Ziprasidone (Geodon) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings This fruit and its juice can dangerously raise blood levels of some antipsychotic drugs such as lurasidone (Latuda), quetiapine (Seroquel), and ziprasidone (Geodon). Nicotine: Smoking can Using gabapentin together with ziprasidone may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. A specific treatment to reverse the effects of ziprasidone does not exist. What are the possible side effects of ziprasidone? Common side effects Drowsiness, extrapyramidal symptoms, headache, dizziness, nausea, constipation, restlessness Rare/serious side effects Some people may develop muscle related side effects while taking ziprasidone. [7] [8] Extrapyramidal symptoms are also common and include tremor, dystonia (sustained or repetitive muscle contractions), akathisia (the feeling of a need to be in motion), parkinsonism, and muscle rigidity; in a 2013 meta-analysis of 15 antipsychotic drugs, ziprasidone ranked 8th for such side effects. [15] Ziprasidone is known to trigger Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4. Gabapentin is eliminated unchanged by the kidney for 100%. This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. Review our list of interactions for Ziprasidone. All interactions are sorted by severity level. Using gabapentin together with ziprasidone may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Dangerous side effects could occur. Geodon side effects. Get emergency medical help if you have signs of an allergic reaction to Geodon: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as ziprasidone have an increased risk of death during treatment. Ziprasidone has serious interactions with at least 98 other drugs. Ziprasidone has moderate interactions with at least 346 other drugs. Ziprasidone has minor interactions with at least 63 other drugs. This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. for drug interactions with ziprasidone due to displacement is minimal. Metabolism and Elimination: Ziprasidone is extensively metabolized after oral administration with only a small amount excreted in the urine (<1%) or feces (<4%) as unchanged drug. Ziprasidone is Ziprasidone may block the effects of agents used to treat Parkinson’s disease such as levodopa/carbidopa (Sinemet®), bromocriptine, pramipexole (Mirapex®), ropinirole (Requip®), and others. The following medications may increase the risk of heart problems when used with ziprasidone: Interactions involving drug absorption are generally less important than interactions affecting drug clearance (metabolism, excretion). • Charcoal, antacids, kapolin-pectin, cholestyramine, fatty acid substitutes, orlistat may bind to drug and form unabsorbable complexes. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Ziprasidone, an atypical antipsychotic, is approved by the US Food and Drug Administration (FDA) for the treatment of schizophrenia, bipolar mania, and acute agitation in individuals with schizophrenia. In schizophrenia treatment, the drug exerts therapeutic antagonism on dopamine (D2) and serotonin (5HT2) receptors. However, due to its antagonism with H1 receptors, ziprasidone may induce We compare the side effects and drug effectiveness of Geodon and Gabapentin. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 450,310 people who take Geodon and Gabapentin, and is updated regularly. There are 729 drugs known to interact with Geodon (ziprasidone), along with 18 disease interactions, and 4 alcohol/food interactions. Of the total drug interactions, 276 are major, 365 are moderate, and 88 are minor.
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