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Are there any serious interactions with gabapentin and other medications? Serious breathing problems can happen if you take gabapentin with drugs that cause severe sleepiness or decreased awareness. Some examples include narcotic opioids, anti-anxiety medicines, antidepressants, and antihistamines. Those taking gabapentin should therefore always disclose to their doctors any medical conditions, other medications (prescription or over the counter), supplements, herbal products, illicit drugs, tobacco products, alcoholic beverages, and dietary choices. Drug Interactions. Gabapentin can interact with various medications, natural products, and food. It is important to be aware of these potential drug interactions. Drug-Drug. Gabapentin can potentially interact with several other medications, and it is important to be aware of these drug-drug interactions. Here are some examples: 1. Opioids. Gabapentin is marketed as Neurontin, Gralise and Horizant and is also available as a generic. Pregabalin is sold under the brand name Lyrica and Lyrica CR. The FDA warns that use of the drugs along with opioid pain medicines or other drugs that depress the central nervous system can severely weaken breathing or cause death. Use WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Both Gabapentin and Prochlorperazine have effects on the CNS and can cause sedation, which might affect the ability to perform skilled tasks (see 'Drugs and Driving' in Guidance on Prescribing). In some cases, use of two or more drugs that have effects on the CNS might also increase the risk of CNS depressant effects (which could range from Gabapentin drug interactions. There are 270 drug interactions with gabapentin. Gabapentin disease interactions. There are 4 disease interactions with gabapentin which include: drug dependence; renal dysfunction; suicidal tendency; hemodialysis Neurontin (gabapentin) is an anti-eleptic medication used to treat seizures that occur with epilepsy, as well as nerve pain associated with shingles. Learn side effects, dosage, drug interactions, warnings, patient labeling, reviews, and more. Gabapentin is an anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Gabapentin enacarbil (brand name Horizant) is a prodrug of gabapentin that has been designed to overcome the limitations of gabapentin, such as poor absorption and a short duration of action. It requires hydrolyzation in the gastrointestinal tract to become active. Gabapentin belongs to the group of medicines known as anticonvulsants. 2. Upsides Gabapentin is usually well tolerated, but like all medications, it can interact with other drugs and substances. It is important to be aware of the potential risks and to be aware of the drugs that should not be taken with gabapentin. Gabapentin is primarily eliminated from the body through the kidneys. Some of the main substances that interact with gabapentin are morphine, caffeine, losartan, ethacrynic acid, phenytoin, mefloquine and magnesium oxide. Some of the side effects caused by gabapentin are teratogenicity, hypoventilation, respiratory failure and myopathy. There are 4 disease interactions with gabapentin. Major Potential Hazard, Moderate plausibility. Applicable conditions: Drug Abuse/Dependence. Anxiolytic, sedative, and hypnotic agents have the potential to cause dependence and abuse. Gabapentin drug interactions (more detail) Does gabapentin interact with my other drugs? Enter medications to view a detailed interaction report using our Drug Interaction Checker . Do not use more than the recommended dose of gabapentin, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Patients should be informed of the potentially fatal risks of interactions between gabapentin and alcohol, and with other medicines that cause CNS depression, particularly opioids. MHRA/CHM advice: Antiepileptic drugs in pregnancy: updated advice following comprehensive safety review (January 2021) Does gabapentin interact with other medicines (drug interactions)? Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal Gabapentin is a prescription drug most commonly prescribed to relieve nerve pain following shingles in adults and the pain of postherpetic neuralgia. Learn about side effects, drug interactions, dosages, warnings, and more.
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