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Gabapentin has less likely benefit adjunctively for bipolar disorder. Gabapentin has clearer efficacy for alcohol craving and withdrawal symptoms and may have a role in adjunctive treatment of opioid dependence. There is no clear evidence for gabapentin therapy in depression, PTSD prevention, OCD, or other types of substance abuse. If you take gabapentin, you or your family should tell the doctor about any unusual changes in your mood, such as agitation, violence, aggression, depression, or talking about wanting to hurt yourself. Serenity at Summit offers clients two options when it comes to safely and comfortably detoxifying from prescription drugs. We have prescription detox locations in New Jersey and Massachusetts, where we offer a personalized, compassionate approach. However, relevant research data have not proven success of newer antiepileptics. This article presents the negative side effects of gabapentin such as psychotic and depressive symptoms, which occur shortly after its use. The use of gabapentin in mood disorders is discussed through these side effects. While studies don’t typically show effectiveness for improving symptoms of depression, there is evidence that gabapentin may have some benefit for anxiety disorders. A rat study found that gabapentin produced behavioral changes suggestive of anxiolysis, or feelings of calmness. In 2019, the FDA added a warning and precaution about the possibility of respiratory depression that states: “There is evidence from case reports, human studies, and animal studies associating gabapentin with serious, life-threatening, or fatal respiratory depression when coadministered with CNS depressants, including opioids, or in the There is no clear evidence for gabapentin therapy in depression, PTSD prevention, OCD, or other types of substance abuse. Limitations of available data include variation in dosing between studies, gabapentin as monotherapy or adjunctive treatment, and differing primary outcomes between trials. Furthermore, other measurements of mood, depression, anger-hostility, fatigue, and physical functioning were more effectively managed with gabapentin compared to a placebo. During the same time, Backonja et al reviewed the effect of gabapentin in 165 diabetic neuropathy patients. In 2019 the FDA issued a warning about the potential risks of respiratory depression in patients taking gabapentin or pregabalin in combination with central nervous system (CNS) depressants such as opioids, antidepressants, and benzodiazepines. The FDA also warned the medication could increase breathing difficulties in patients with underlying But wait, there’s more! Depression and suicidal thoughts can also make an unwelcome appearance. It’s as if gabapentin decided to invite the gloomiest rain cloud to your mental picnic. These feelings can range from a persistent low mood to more severe depressive symptoms. In some cases, patients may experience thoughts of self-harm or suicide. Gabapentin isn’t usually used to treat anxiety alone. More often, it’s given to ease anxiety symptoms for someone who also has depression or bipolar disorder. (Anxiety is commonly Gabapentin has less likely benefit adjunctively for bipolar disorder. Gabapentin has clearer efficacy for alcohol craving and withdrawal symptoms and may have a role in adjunctive treatment of opioid dependence. There is no clear evidence for gabapentin therapy in depression, PTSD prevention, OCD, or other types of substance abuse. Only two groups have described their experience with gabapentin in either bipolar or unipolar depression (Young et al., 1997, Ghaemi et al., 1998, Young et al., 1999). To our knowledge, this is the first report on the extended adjunctive use of gabapentin in a large cohort of depressed patients resistant to conventional antidepressants. It is imperative to screen, identify, and appropriately manage patients with underlying psychiatric disorders prior to initiating pain management with gabapentin. Therefore, it is crucial to raise awareness of gabapentin as a potential cause of depression, aggressive behavior, and suicidal ideation. Keywords: Chronic low back pain, gabapentin Evidence does not support the use of gabapentin for bipolar disorder, major depressive disorder (MDD), posttraumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), stimulant use disorder, or opioid withdrawal. Seven studies reported a significant reduction in severity scores for depression, with gabapentin therapy. Four studies reported significant improvement in bipolar severity as measured by BPRS, AIRP and CGI-BP. Sedation was the most common side effect as reported in six studies [19,21,23,26,33,36].
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