The mechanism of action of the drugs effective in treating OCD (clomipramine, a non-selective serotonin reuptake inhibitor, and the selective serotonin reuptake inhibitors [SSRIs]: citalopram, fluoxetine, fluvoxamine, sertraline and paroxetine) has given rise to the hypothesis that deficient serotonin function is a key element in the pathophysiology of OCD. Other medications that modulate GABA function, such as gabapentin and pregabalin, have been studied for their potential in treating OCD symptoms. While results have been mixed, some patients report benefits from these medications, particularly in managing anxiety associated with OCD. I wouldn’t recommend Gabapentin for OCD. It works well for anxiety if you think you might be having problems with GABA. It also desensitizes nerve endings. And when you begin it has wicked side effects so be careful for the first couple of weeks. Source: Have OCD Study behavioral medicine And best friends with behaviorist taking gabapentin. Prolonged administration of selective serotonin reuptake inhibitors (SSRIs) is most effective. Better results can be obtained with a SSRI combined with cognitive behavioral therapy (CBT) or the similarly oriented exposure and response prevention (ERP). One study on 40 people showed that gabapentin enhanced the effectiveness of SSRIs at alleviating early OCD symptoms . Similarly, pregabalin enhanced the effectiveness of conventional OCD therapy and reduced the symptoms by 26% in a case series of 12 patients. Gabapentin has been approved by the United States (US) Food and Drug Administration (FDA) for postherpetic neuralgia and as adjunctive therapy for focal seizures. 1 However, a recent analysis of US physician office-based prescription practices between 2011 and 2016 found that less than one percent of gabapentin prescriptions are for such indications. 2 In 2020, gabapentin was reported to be Welcome to /r/gabapentin, here we primarily discuss issues pertaining to the medical, prescribed use of Gabapentin, Lyrica and Phenibut, as well as other Gaba related drugs. This IS NOT the subreddit for discussion of how to get high or otherwise abuse GP. Objective: This article reviews evidence-based psychiatric uses of gabapentin, along with associated risks. Method of Research: An extensive literature review was conducted, primarily of articles searchable in PubMed, relating to psychiatric uses, safety, and adverse effects of gabapentin. Results: Evidence supports gabapentin as a treatment for alcohol withdrawal and alcohol use disorder The present pattern of results suggests that glutamatergic medications such as gabapentin and memantine adjuvant to a standard treatment with an SSRI have no additional positive impact on patients with OCD, as measured with the Y-BOCS. There is no clear evidence for gabapentin therapy in depression, PTSD prevention, OCD, or other types of substance abuse. Limitations of available data include variation in dosing between studies, gabapentin as monotherapy or adjunctive treatment, and differing primary outcomes between trials. Some anticonvulsant drugs (such as gabapentin [Neurontin] or pregabalin [Lyrica]), some blood pressure medications (such as propranolol), and some atypical antipsychotics (such as aripiprazole A recent systematic review concluded that gabapentin for alcohol use disorder may be safe only as an adjuvant but not as a monotherapy and that there is insufficient evidence to support its use as a treatment for other substance dependencies or for depression, OCD, PTSD, and schizoaffective disorder . The largest proportion of off-label Evidence does not support the use of gabapentin for bipolar disorder, major depressive disorder (MDD), posttraumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), stimulant use disorder, or opioid withdrawal. Adding gabapentin to fluoxetine in the treatment of OCD seems to shorten the time to onset of fluoxetine's anti-obsessive effect without a significant increase in adverse effects. In order to accelerate the clinical response, co-administration of fluoxetine and gabapentin may be a preferable strateg Gabapentin is not a typical medication for OCD, although it is often prescribed “off-label” if a medical provider deems it necessary. Thus, researchers have found that gabapentin can ease OCD symptoms in some people. (PTSD), and obsessive-compulsive disorder (OCD) (9 –12). The pharmacological evidence cited for gabapentin ’susein various psychiatric disorders is based on an incomplete un-derstanding of its mechanism of action. It was once believed that gabapentin had anxiolytic properties and increased gamma-aminobutyric acid levels in the brain, but Obsessive-Compulsive Disorder. Only 1 study has evaluated gabapentin use for obsessive-compulsive disorder (OCD). Onder et al 68 studied fluoxetine monotherapy versus fluoxetine with adjunctive gabapentin in controlling OCD symptoms. Forty patients were randomized (open-label) to fluoxetine 20 mg/d or fluoxetine 20 mg/d with gabapentin 600 mg/d. Experts rated patients' symptoms of OCD with the YBOCS and CGI (Global Clinical Impression scale) at baseline and then 2,4, and 8 weeks later. While adjuvant gabapentin had reduced symptoms of OCD by the second week, there was no advantage at the end of the study. We observed an improvement in OCD symptoms with both treatment options (fluoxetine alone or fluoxetine plus gabapentin co-administration). However, fluoxetine plus gabapentin group had a significantly greater decrease at the second week than fluoxetine group, as assessed with Y-BOCS and CGI-S, which means that decrease of symptom severity was accelerated by adding gabapentine on fluoxetine.
Articles and news, personal stories, interviews with experts.
Photos from events, contest for the best costume, videos from master classes.
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |