Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. Research presented at the annual meeting of the North American Menopause Society (NAMS) indicates that an investigational extended release (ER) formulation of gabapentin (Serada, Depomed) is effective for the treatment of hot flashes and sleep Although the FDA has not approved Neurontin for hot flashes, there’s some good evidence that it’s effective. A study from the University of Rochester showed that gabapentin was effective in reducing hot flashes in patients with a damaged hypothalamus, and there have been over 20 studies on menopausal women that show similar results. Dietary supplements people often use for menopause symptoms include: Plant estrogens. Some plants have substances that are like the hormone estrogen. Examples are soy, red clover and flaxseed. But studies most often have found that plant estrogens help menopause symptoms little or not at all. Research is ongoing. Black cohosh. Gabapentin is a drug that doctors sometimes prescribe off-label to reduce hot flashes during menopause. Instead of affecting hormones, experts think it may act on the hypothalamus, The North American Menopause society and the American College of Obstetricians and Gynecologists recommend the use of gabapentin as an option for managing hot flashes in women who are unwilling to take estrogen-containing supplements. earched the PubMed, MEDLINE, EMBASE, and CENTRAL databases for English-language articles published until June, 2018. The following search terms were used: “menopause,” “hot flushes,” “vasomotor symptoms,” “gabapentin,” and “non-hormonal therapy.” Primary outcomes were frequency, duration, and composite score of hot flushes. Secondary outcomes were adverse effects and Other agents that have been used to alleviate hot flashes include belladonna/ergotamine tartrate/phenobarbital combination, dong quai, evening primrose oil, gabapentin, ginseng, mirtazapine Objective: Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gabapentin for treating menopausal hot flushes via a meta-analysis. Gabapentin Helps Hot Flashes. In BREEZE 3, 600 postmenopausal women (mean age, 54.0 years; mean time since last menstrual period, 114 months; mean body mass index, 29.4 kg/m²) were randomized to Gabapentin is usually used to control epilepsy or chronic nerve pain. It also reduces menopausal hot flushes. Gabapentin in higher doses has been shown to be as effective as estrogen in reducing the severity and frequency of hot flushes. in women include gabapentin, clonidine, venlafaxine or selective serotonin reuptake inhibitors (SSRIs). The treatment option depends on the individual. Gabapentin Brand name: Neurontin® available as 100mg, 300mg, 400mg, 600mg and 800mg capsules. Also available in generic brands. Gabapentin is usually used to control epilepsy or chronic These treatments are largely prescribed “off-label”. Off-label means use outside the specific purpose for which the drug was approved by Australia’s medicines regulator, the Therapeutic Goods Administration. Doctors prescribing off-label have a responsibility to be well-informed about the product and to base its use on scientific evidence. While gabapentin is primarily used to treat seizures and nerve pain, recent studies have shown that it can also be beneficial in managing menopause symptoms. So, how does gabapentin work? This medication works by affecting the chemical messengers in the brain that are associated with menopause symptoms. To evaluate the efficacy and safety of gabapentin for the treatment of hot flashes in women with menopause and/or breast cancer, we performed a search of the MEDLINE database (1966-March 2008) and International Pharmaceutical Abstracts, as well as manually searching reference articles for relevant articles and abstracts; 10 clinical studies The Menopause-Specific Quality-of-Life vasomotor score decreased by 1.7 (95% CI: 1.3-2.1; P < 0.001) in the gabapentin group. These women reported greater dizziness (18%), unsteadiness (14%), and drowsiness (12%) at week 1 compared with those taking placebo; however, these symptoms improved by week 2 and returned to baseline levels by week 4. Gabapentin is effective in reducing the frequency and severity of hot flashes, particularly for those experiencing menopausal symptoms. Originally used for epilepsy and neuropathic pain, it has been found to offer significant relief from hot flashes. Key Benefits: Hot flashes are a common symptom of menopause, affecting approximately 75% of women.
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