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Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults. Cochrane Database Syst Rev. 2013(6):CD010609. Xu XM, Liu Y, Dong MX, Zou DZ, Wei YD. To describe and assess the evidence from controlled trials on the efficacy and tolerability of gabapentin/gabapentin enacarbil or pregabalin for preventing migraine attacks in adult patients with episodic migraine. The objective of our study was to assess the efficacy and safety of gabapentin in the prophylaxis of migraine in patients refractory to other prophylactic treatments. The study included 67 migraine patients, 55 women and 12 men; 52 patients completed this prospective, open-label study. Gabapentin shows to have an effective therapeutic action in the prophylactic treatment of migraine. Our observations indicate that gabapentin is well tolerated by patients and that reduces headache frequency and use of symptomatic drugs in both groups. Gabapentin is an effective prophylactic agent for patients with migraine. In addition, gabapentin appears generally well tolerated with mild to moderate somnolence and dizziness. Gabapentin is not a first-line drug for treating migraine, so your provider won’t prescribe it to you unless you’ve tried other preventive medications like antidepressants, beta-blockers, and/or migraine-specific preventative drugs that block calcitonin gene-related peptide (CGRP), including Aimovig, Ajovy, Vyepti, Nurtec, Qulipta, and This double-blind, randomized, placebo-controlled, multicenter study in patients with migraine (with or without aura) was conducted to determine the efficacy and safety of gabapentin in migraine prophylaxis. Objective While there are several trials that support the efficacy of various drugs for migraine prophylaxis against placebo, there is limited evidence addressing the comparative safety and efficacy of these drugs. We conducted a systematic review and network meta-analysis to facilitate comparison between drugs for migraine prophylaxis. Methods We searched MEDLINE, EMBASE, CENTRAL, and Also, gabapentin reduced the headache frequency by 50% or greater in 45% patients compared with only 16% patients on placebo. Randomized, double-blind, placebo-controlled clinical study 10 of gabapentin enacarbil for migraine prophylaxis concluded that gabapentin was not significantly superior to placebo for migraine prophylaxis. significant effect of gabapentin compared with placebo for migraine prophylaxis. In comparison with other widely used migraine preventive drugs, the estimated effect size for gabapentin not only fails to reach statistical significance, but also has a much lower magnitude of effect. For the present review, researchers in The Cochrane Collaboration reviewed the evidence about the effects of gabapentin and two related drugs (pregabalin and gabapentin enacarbil) in adult patients (≥ 16 years of age) with 'episodic' migraine (headache on < 15 days per month). Does gabapentin (Neurontin) help prevent episodic migraine? Evidence-Based Answer Gabapentin does not decrease the frequency of migraine headaches and is not recommended for prophylactic After treating acute migraines, all migraine patients should be evaluated for preventive therapy. Preventive therapy aims to decrease the frequency, severity, and duration of migraine attacks. Furthermore, preventative therapy can increase responsiveness to acute migraine therapy and improve the quality of life. Guidance from NICE and SIGN agrees that gabapentin should not be considered as a prophylactic treatment for migraine [NICE, 2021; SIGN, 2023]. Gabapentin is no better than placebo for prophylactic treatment of migraine in adults, is commonly associated with adverse events and there is an increased risk of addiction . Tronvik E, Stovner LJ, Helde G, Sand T, Bovim G. Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial. JAMA. 2003;289(1):65–69. doi: 10.1001/jama.289.1.65. [Google Scholar] 20. Mathew NT, Rapoport A, Saper J, et al. Efficacy of gabapentin in migraine prophylaxis. Gabapentin Gabapentin’s mode of action in migraine is unclear (66). It interacts with the α 2δ-subunit of the calcium channel and increases the concentration and probably the syn-thesis of brain γ-aminobutyric acid (GABA). Gabapentin binds to gabapentin-binding protein—a novel, membrane-associated protein in the outer layers of the
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